HRH3 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of HRH3 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of HRH3 at tissue level.

III. Associated gene sets

GO_0007197Biological processadenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway
GO_0007268Biological processchemical synaptic transmission
GO_0007187Biological processG protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
GO_0098664Biological processG protein-coupled serotonin receptor signaling pathway
GO_0007269Biological processneurotransmitter secretion
GO_0098793Cellular componentpresynapse
GO_0030425Cellular componentdendrite
GO_0005886Cellular componentplasma membrane
GO_0045202Cellular componentsynapse
GO_0004993Molecular functionG protein-coupled serotonin receptor activity
GO_0016907Molecular functionG protein-coupled acetylcholine receptor activity
GO_0004969Molecular functionhistamine receptor activity

IV. Literature review

[source]
Gene nameHRH3
Protein nameHistamine H3 receptor isoform 5
Histamine receptor H3
Histamine H3 receptor isoform 1
Histamine H3 receptor isoform 4
Histamine H3 receptor isoform 2
Histamine H3 receptor isoform 6
Histamine H3 receptor (H3R) (HH3R) (G-protein coupled receptor 97)
Histamine H3 receptor isoform 3
SynonymsGPCR97
hCG_41769
DescriptionFUNCTION: The H3 subclass of histamine receptors could mediate the histamine signals in CNS and peripheral nervous system. Signals through the inhibition of adenylate cyclase and displays high constitutive activity (spontaneous activity in the absence of agonist). Agonist stimulation of isoform 3 neither modified adenylate cyclase activity nor induced intracellular calcium mobilization.

AccessionsENST00000317393.10
Q8NI50
Q8NI49
Q8WXZ9
Q8WY00
Q548M6
A0A0A0MR48
Q9Y5N1
ENST00000340177.10 [Q9Y5N1-1]
Q8WY01