EFNB1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0042102Biological processpositive regulation of T cell proliferation
GO_0048013Biological processephrin receptor signaling pathway
GO_0001755Biological processneural crest cell migration
GO_0042098Biological processT cell proliferation
GO_0031295Biological processT cell costimulation
GO_0007155Biological processcell adhesion
GO_0007267Biological processcell-cell signaling
GO_0009880Biological processembryonic pattern specification
GO_2000785Biological processregulation of autophagosome assembly
GO_0007411Biological processaxon guidance
GO_0098978Cellular componentglutamatergic synapse
GO_0005886Cellular componentplasma membrane
GO_0045121Cellular componentmembrane raft
GO_0070062Cellular componentextracellular exosome
GO_0042734Cellular componentpresynaptic membrane
GO_0009986Cellular componentcell surface
GO_0045202Cellular componentsynapse
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0046875Molecular functionephrin receptor binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameEFNB1
Protein nameEphrin-B1 (EFL-3) (ELK ligand) (ELK-L) (EPH-related receptor tyrosine kinase ligand 2) (LERK-2) [Cleaved into: Ephrin-B1 C-terminal fragment (Ephrin-B1 CTF); Ephrin-B1 intracellular domain (Ephrin-B1 ICD)]
SynonymsEPLG2
LERK2
EFL3
DescriptionFUNCTION: Cell surface transmembrane ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development . Binding to Eph receptors residing on adjacent cells leads to contact-dependent bidirectional signaling into neighboring cells . Shows high affinity for the receptor tyrosine kinase EPHB1/ELK . Can also bind EPHB2 and EPHB3 . Binds to, and induces collapse of, commissural axons/growth cones in vitro (By similarity). May play a role in constraining the orientation of longitudinally projecting axons (By similarity). .

AccessionsP98172
ENST00000204961.5