RGS17 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0001975Biological processresponse to amphetamine
GO_0007186Biological processG protein-coupled receptor signaling pathway
GO_0009968Biological processnegative regulation of signal transduction
GO_0045202Cellular componentsynapse
GO_0005886Cellular componentplasma membrane
GO_0043005Cellular componentneuron projection
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0005096Molecular functionGTPase activator activity
GO_0005515Molecular functionprotein binding
GO_0003924Molecular functionGTPase activity

IV. Literature review

[source]
Gene nameRGS17
Protein nameRegulator of G-protein signaling 17 (RGS17)
SynonymsRGSZ2
DescriptionFUNCTION: Regulates G protein-coupled receptor signaling cascades, including signaling via muscarinic acetylcholine receptor CHRM2 and dopamine receptor DRD2. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form . Binds selectively to GNAZ and GNAI2 subunits, accelerates their GTPase activity and regulates their signaling activities. Negatively regulates mu-opioid receptor-mediated activation of the G-proteins (By similarity). .

AccessionsQ9UGC6
ENST00000206262.2
ENST00000367225.6