PSMC4 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0001824Biological processblastocyst development
GO_1901800Biological processpositive regulation of proteasomal protein catabolic process
GO_0006508Biological processproteolysis
GO_0043161Biological processproteasome-mediated ubiquitin-dependent protein catabolic process
GO_0000502Cellular componentproteasome complex
GO_0016234Cellular componentinclusion body
GO_0022624Cellular componentproteasome accessory complex
GO_0031597Cellular componentcytosolic proteasome complex
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0008540Cellular componentproteasome regulatory particle, base subcomplex
GO_0045202Cellular componentsynapse
GO_0016020Cellular componentmembrane
GO_0005634Cellular componentnucleus
GO_0005515Molecular functionprotein binding
GO_0036402Molecular functionproteasome-activating activity
GO_0016887Molecular functionATP hydrolysis activity
GO_0005524Molecular functionATP binding

IV. Literature review

[source]
Gene namePSMC4
Protein name26S proteasome regulatory subunit 6B (26S proteasome AAA-ATPase subunit RPT3) (Proteasome 26S subunit ATPase 4)
26S proteasome regulatory subunit 6B (26S proteasome AAA-ATPase subunit RPT3) (MB67-interacting protein) (MIP224) (Proteasome 26S subunit ATPase 4) (Tat-binding protein 7) (TBP-7)
SynonymsMIP224
hCG_43346
TBP7
DescriptionFUNCTION: Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC4 belongs to the heterohexameric ring of AAA (ATPases associated with diverse cellular activities) proteins that unfolds ubiquitinated target proteins that are concurrently translocated into a proteolytic chamber and degraded into peptides. .

FUNCTION: Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC4 belongs to the heterohexameric ring of AAA (ATPases associated with diverse cellular activities) proteins that unfolds ubiquitinated target proteins that are concurrently translocated into a proteolytic chamber and degraded into peptides. .

AccessionsENST00000157812.7 [P43686-1]
A8K2M0
ENST00000630857.1 [P43686-2]
ENST00000455878.2 [P43686-2]
ENST00000629691.3 [P43686-1]
P43686