DNM1 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
glutamatergic neuron	12 studies	64% ± 23%	Explore
GABAergic neuron	11 studies	48% ± 26%	Explore
oligodendrocyte precursor cell	10 studies	28% ± 10%	Explore
amacrine cell	8 studies	36% ± 7%	Explore
retinal rod cell	7 studies	24% ± 7%	Explore
fibroblast	7 studies	19% ± 4%	Explore
neuron	6 studies	40% ± 18%	Explore
interneuron	6 studies	56% ± 24%	Explore
macrophage	6 studies	30% ± 14%	Explore
retinal ganglion cell	6 studies	77% ± 13%	Explore
retinal cone cell	6 studies	32% ± 4%	Explore
endothelial cell	5 studies	35% ± 22%	Explore
retinal bipolar neuron	4 studies	28% ± 5%	Explore
granule cell	4 studies	47% ± 10%	Explore
retina horizontal cell	4 studies	20% ± 3%	Explore
GABAergic interneuron	3 studies	49% ± 8%	Explore
OFF-bipolar cell	3 studies	45% ± 23%	Explore
ON-bipolar cell	3 studies	51% ± 23%	Explore
glycinergic amacrine cell	3 studies	35% ± 10%	Explore
rod bipolar cell	3 studies	25% ± 3%	Explore
astrocyte	3 studies	20% ± 5%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
brain	16 studies	38% ± 23%	Explore
eye	8 studies	25% ± 6%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
brain	95%	32337.92	2501 / 2642	98%	47.56	691 / 705
breast	84%	3126.62	385 / 459	77%	6.02	862 / 1118
kidney	75%	2499.10	67 / 89	79%	18.91	708 / 901
uterus	72%	2680.01	123 / 170	80%	11.06	365 / 459
skin	86%	3033.20	1552 / 1809	53%	5.45	248 / 472
esophagus	53%	1782.18	765 / 1445	85%	13.13	156 / 183
bladder	62%	2067.95	13 / 21	56%	4.76	283 / 504
intestine	51%	1376.95	494 / 966	63%	5.71	332 / 527
pancreas	19%	385.65	61 / 328	92%	13.01	163 / 178
adrenal gland	26%	615.14	66 / 258	74%	28.63	170 / 230
ovary	6%	128.72	10 / 180	86%	9.84	371 / 430
prostate	64%	1936.69	156 / 245	25%	1.12	127 / 502
lung	22%	518.78	129 / 578	66%	6.37	767 / 1155
adipose	89%	4345.60	1068 / 1204	0%	0	0 / 0
stomach	18%	437.87	65 / 359	70%	6.00	200 / 286
eye	0%	0	0 / 0	79%	8.65	63 / 80
tonsil	0%	0	0 / 0	58%	6.85	26 / 45
thymus	34%	781.28	219 / 653	7%	0.33	42 / 605
liver	8%	218.04	18 / 226	20%	2.95	82 / 406
heart	22%	529.17	188 / 861	0%	0	0 / 0
blood vessel	19%	481.55	250 / 1335	0%	0	0 / 0
lymph node	0%	0	0 / 0	17%	0.66	5 / 29
muscle	2%	47.91	18 / 803	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
peripheral blood	0%	0	0 / 929	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
spleen	0%	0	0 / 241	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

III. Associated gene sets

GO_0051260	Biological process	protein homooligomerization
GO_0031623	Biological process	receptor internalization
GO_0050804	Biological process	modulation of chemical synaptic transmission
GO_0006897	Biological process	endocytosis
GO_0006898	Biological process	receptor-mediated endocytosis
GO_0016185	Biological process	synaptic vesicle budding from presynaptic endocytic zone membrane
GO_0007032	Biological process	endosome organization
GO_0099050	Biological process	vesicle scission
GO_0099049	Biological process	clathrin coat assembly involved in endocytosis
GO_0097494	Biological process	regulation of vesicle size
GO_0051289	Biological process	protein homotetramerization
GO_0098978	Cellular component	glutamatergic synapse
GO_0098793	Cellular component	presynapse
GO_0030117	Cellular component	membrane coat
GO_0005886	Cellular component	plasma membrane
GO_0005874	Cellular component	microtubule
GO_0030139	Cellular component	endocytic vesicle
GO_0070062	Cellular component	extracellular exosome
GO_0001917	Cellular component	photoreceptor inner segment
GO_0042583	Cellular component	chromaffin granule
GO_0098684	Cellular component	photoreceptor ribbon synapse
GO_0098835	Cellular component	presynaptic endocytic zone membrane
GO_0045202	Cellular component	synapse
GO_0005737	Cellular component	cytoplasm
GO_0042995	Cellular component	cell projection
GO_0005905	Cellular component	clathrin-coated pit
GO_0019003	Molecular function	GDP binding
GO_0042803	Molecular function	protein homodimerization activity
GO_0005547	Molecular function	phosphatidylinositol-3,4,5-trisphosphate binding
GO_0005546	Molecular function	phosphatidylinositol-4,5-bisphosphate binding
GO_0019901	Molecular function	protein kinase binding
GO_0042802	Molecular function	identical protein binding
GO_0005525	Molecular function	GTP binding
GO_0008017	Molecular function	microtubule binding
GO_0003723	Molecular function	RNA binding
GO_0005515	Molecular function	protein binding
GO_0003924	Molecular function	GTPase activity

IV. Literature review

[source]

Gene name	DNM1
Protein name	dynamin GTPase (EC 3.6.5.5) Dynamin 1 Dynamin-1 (EC 3.6.5.5) (Dynamin) (Dynamin I)
Synonyms	DNM
Description	FUNCTION: Catalyzes the hydrolysis of GTP and utilizes this energy to mediate vesicle scission and participates in many forms of endocytosis, such as clathrin-mediated endocytosis or synaptic vesicle endocytosis as well as rapid endocytosis (RE) . Associates to the membrane, through lipid binding, and self-assembles into rings and stacks of interconnected rings through oligomerization to form a helical polymer around the vesicle membrane leading to constriction of invaginated coated pits around their necks . Self-assembly of the helical polymer induces membrane tubules narrowing until the polymer reaches a length sufficient to trigger GTP hydrolysis . Depending on the curvature imposed on the tubules, membrane detachment from the helical polymer upon GTP hydrolysis can cause spontaneous hemifission followed by complete fission . May play a role in regulating early stages of clathrin-mediated endocytosis in non-neuronal cells through its activation by dephosphorylation via the signaling downstream of EGFR . Controls vesicle size at a step before fission, during formation of membrane pits, at hippocampal synapses (By similarity). Controls plastic adaptation of the synaptic vesicle recycling machinery to high levels of activity (By similarity). Mediates rapid endocytosis (RE), a Ca(2+)-dependent and clathrin- and K(+)-independent process in chromaffin cells (By similarity). Microtubule-associated force-producing protein involved in producing microtubule bundles and able to bind and hydrolyze GTP (By similarity). Through its interaction with DNAJC6, acts during the early steps of clathrin-coated vesicle (CCV) formation . .
Accessions	A0A0U1RQP1 ENST00000706053.1 ENST00000475805.5 [Q05193-5] ENST00000634267.2 A0A1B0GUX5 A0A1B0GU67 A0A0D9SFB1 A0A1B0GVK6 ENST00000625457.1 Q05193 A0A994J7J4 ENST00000637999.1 ENST00000636201.1 ENST00000627061.2 ENST00000341179.11 [Q05193-3] A0A994J5P0 A0A0D9SFE4 ENST00000486160.3 [Q05193-2] ENST00000372923.8 [Q05193-1] ENST00000627543.2 [Q05193-3] A0A0D9SFP1 ENST00000706054.1 H7C5U0 ENST00000482638.6 ENST00000628346.2 ENST00000393594.7 [Q05193-5] ENST00000636280.1

DNM1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review