Name | Number of supported studies | Average coverage | |
---|---|---|---|
peripheral blood | 18 studies | 40% ± 16% | |
lung | 16 studies | 33% ± 13% | |
kidney | 6 studies | 25% ± 6% | |
brain | 6 studies | 31% ± 10% | |
intestine | 5 studies | 32% ± 11% | |
lymph node | 5 studies | 27% ± 12% | |
liver | 5 studies | 31% ± 11% | |
placenta | 4 studies | 30% ± 12% | |
bone marrow | 4 studies | 46% ± 20% | |
eye | 4 studies | 23% ± 10% | |
uterus | 4 studies | 43% ± 11% | |
breast | 4 studies | 29% ± 12% | |
pancreas | 3 studies | 46% ± 22% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
esophagus | 100% | 16499.48 | 1445 / 1445 | 100% | 120.65 | 183 / 183 |
ovary | 100% | 16266.13 | 180 / 180 | 100% | 189.62 | 430 / 430 |
thymus | 100% | 15887.31 | 652 / 653 | 100% | 171.02 | 605 / 605 |
skin | 100% | 14962.03 | 1806 / 1809 | 100% | 205.30 | 472 / 472 |
lung | 100% | 30792.10 | 578 / 578 | 100% | 128.94 | 1152 / 1155 |
uterus | 100% | 19918.38 | 170 / 170 | 100% | 132.45 | 457 / 459 |
brain | 100% | 12541.38 | 2630 / 2642 | 100% | 245.38 | 705 / 705 |
breast | 100% | 22674.83 | 459 / 459 | 99% | 151.64 | 1112 / 1118 |
prostate | 100% | 15278.34 | 244 / 245 | 100% | 92.47 | 500 / 502 |
intestine | 100% | 16979.75 | 963 / 966 | 99% | 98.64 | 524 / 527 |
liver | 100% | 8282.50 | 225 / 226 | 99% | 82.81 | 403 / 406 |
bladder | 100% | 19130.14 | 21 / 21 | 99% | 130.16 | 498 / 504 |
adrenal gland | 100% | 13901.01 | 258 / 258 | 99% | 117.00 | 227 / 230 |
kidney | 100% | 11896.08 | 89 / 89 | 99% | 135.25 | 889 / 901 |
stomach | 87% | 8979.57 | 312 / 359 | 99% | 114.68 | 284 / 286 |
pancreas | 53% | 2766.57 | 175 / 328 | 98% | 167.04 | 175 / 178 |
adipose | 100% | 27311.36 | 1204 / 1204 | 0% | 0 | 0 / 0 |
blood vessel | 100% | 25136.63 | 1335 / 1335 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 100% | 90.86 | 80 / 80 |
lymph node | 0% | 0 | 0 / 0 | 100% | 273.57 | 29 / 29 |
peripheral blood | 100% | 54410.05 | 929 / 929 | 0% | 0 | 0 / 0 |
spleen | 100% | 28791.86 | 241 / 241 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 100% | 127.35 | 45 / 45 |
ureter | 0% | 0 | 0 / 0 | 100% | 75.23 | 1 / 1 |
heart | 100% | 11368.59 | 858 / 861 | 0% | 0 | 0 / 0 |
muscle | 81% | 4281.66 | 649 / 803 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0007584 | Biological process | response to nutrient |
GO_0007194 | Biological process | negative regulation of adenylate cyclase activity |
GO_0008283 | Biological process | cell population proliferation |
GO_0007213 | Biological process | G protein-coupled acetylcholine receptor signaling pathway |
GO_0051924 | Biological process | regulation of calcium ion transport |
GO_0007165 | Biological process | signal transduction |
GO_0001973 | Biological process | G protein-coupled adenosine receptor signaling pathway |
GO_0051301 | Biological process | cell division |
GO_0050805 | Biological process | negative regulation of synaptic transmission |
GO_0007186 | Biological process | G protein-coupled receptor signaling pathway |
GO_0045955 | Biological process | negative regulation of calcium ion-dependent exocytosis |
GO_2000179 | Biological process | positive regulation of neural precursor cell proliferation |
GO_0030335 | Biological process | positive regulation of cell migration |
GO_0007193 | Biological process | adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway |
GO_0140199 | Biological process | negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process |
GO_0007189 | Biological process | adenylate cyclase-activating G protein-coupled receptor signaling pathway |
GO_0046628 | Biological process | positive regulation of insulin receptor signaling pathway |
GO_2001234 | Biological process | negative regulation of apoptotic signaling pathway |
GO_0008284 | Biological process | positive regulation of cell population proliferation |
GO_0032930 | Biological process | positive regulation of superoxide anion generation |
GO_0007214 | Biological process | gamma-aminobutyric acid signaling pathway |
GO_0070374 | Biological process | positive regulation of ERK1 and ERK2 cascade |
GO_1904707 | Biological process | positive regulation of vascular associated smooth muscle cell proliferation |
GO_0035810 | Biological process | positive regulation of urine volume |
GO_0098992 | Cellular component | neuronal dense core vesicle |
GO_0030496 | Cellular component | midbody |
GO_0005886 | Cellular component | plasma membrane |
GO_0016020 | Cellular component | membrane |
GO_0005813 | Cellular component | centrosome |
GO_1903561 | Cellular component | extracellular vesicle |
GO_0005654 | Cellular component | nucleoplasm |
GO_0070062 | Cellular component | extracellular exosome |
GO_0030425 | Cellular component | dendrite |
GO_0005829 | Cellular component | cytosol |
GO_0045202 | Cellular component | synapse |
GO_0005737 | Cellular component | cytoplasm |
GO_0044297 | Cellular component | cell body |
GO_0005834 | Cellular component | heterotrimeric G-protein complex |
GO_0031683 | Molecular function | G-protein beta/gamma-subunit complex binding |
GO_0001664 | Molecular function | G protein-coupled receptor binding |
GO_0005525 | Molecular function | GTP binding |
GO_0046872 | Molecular function | metal ion binding |
GO_0005515 | Molecular function | protein binding |
GO_0003924 | Molecular function | GTPase activity |
Gene name | GNAI2 |
Protein name | G protein subunit alpha i2 Guanine nucleotide-binding protein G(i) subunit alpha-2 (Adenylate cyclase-inhibiting G alpha protein) Guanine nucleotide-binding regulatory protein |
Synonyms | GNAI2B |
Description | FUNCTION: Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(i) proteins are involved in hormonal regulation of adenylate cyclase: they inhibit the cyclase in response to beta-adrenergic stimuli. May play a role in cell division. .; FUNCTION: [Isoform sGi2]: Regulates the cell surface density of dopamine receptors DRD2 by sequestrating them as an intracellular pool. . FUNCTION: Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(i) proteins are involved in hormonal regulation of adenylate cyclase: they inhibit the cyclase in response to beta-adrenergic stimuli. May play a role in cell division. . |
Accessions | F8WBG4 Q99061 ENST00000451956.1 [P04899-3] F8WE78 ENST00000441156.5 ENST00000266027.9 [P04899-6] Q96C71 ENST00000313601.11 [P04899-1] ENST00000422163.5 [P04899-5] ENST00000440628.5 [P04899-6] P04899 ENST00000446079.5 |