VDAC1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0098656Biological processmonoatomic anion transmembrane transport
GO_0030855Biological processepithelial cell differentiation
GO_0006090Biological processpyruvate metabolic process
GO_0007612Biological processlearning
GO_1905091Biological processpositive regulation of parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization
GO_0007270Biological processneuron-neuron synaptic transmission
GO_2000378Biological processnegative regulation of reactive oxygen species metabolic process
GO_1903146Biological processregulation of autophagy of mitochondrion
GO_0110099Biological processnegative regulation of calcium import into the mitochondrion
GO_0006820Biological processmonoatomic anion transport
GO_0043066Biological processnegative regulation of apoptotic process
GO_0001662Biological processbehavioral fear response
GO_0006915Biological processapoptotic process
GO_0036444Biological processcalcium import into the mitochondrion
GO_0005886Cellular componentplasma membrane
GO_0042645Cellular componentmitochondrial nucleoid
GO_0016020Cellular componentmembrane
GO_0005739Cellular componentmitochondrion
GO_0045121Cellular componentmembrane raft
GO_0031966Cellular componentmitochondrial membrane
GO_0070062Cellular componentextracellular exosome
GO_0005757Cellular componentmitochondrial permeability transition pore complex
GO_0045202Cellular componentsynapse
GO_0046930Cellular componentpore complex
GO_0005741Cellular componentmitochondrial outer membrane
GO_0005634Cellular componentnucleus
GO_0015288Molecular functionporin activity
GO_0015485Molecular functioncholesterol binding
GO_0097001Molecular functionceramide binding
GO_0019901Molecular functionprotein kinase binding
GO_0042802Molecular functionidentical protein binding
GO_0008308Molecular functionvoltage-gated monoatomic anion channel activity
GO_0031210Molecular functionphosphatidylcholine binding
GO_0008142Molecular functionoxysterol binding
GO_0044325Molecular functiontransmembrane transporter binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameVDAC1
Protein nameVoltage-dependent anion-selective channel protein 1
Alternative protein VDAC1
Voltage-dependent anion-selective channel protein 1 (VDAC-1) (hVDAC1) (Outer mitochondrial membrane protein porin 1) (Plasmalemmal porin) (Porin 31HL) (Porin 31HM)
SynonymsVDAC
DescriptionFUNCTION: Forms a channel through the mitochondrial outer membrane and also the plasma membrane. The channel at the outer mitochondrial membrane allows diffusion of small hydrophilic molecules; in the plasma membrane it is involved in cell volume regulation and apoptosis. It adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV. The open state has a weak anion selectivity whereas the closed state is cation-selective . Binds various signaling molecules, including the sphingolipid ceramide, the phospholipid phosphatidylcholine, and the sterols cholesterol and oxysterol . In depolarized mitochondria, acts downstream of PRKN and PINK1 to promote mitophagy or prevent apoptosis; polyubiquitination by PRKN promotes mitophagy, while monoubiquitination by PRKN decreases mitochondrial calcium influx which ultimately inhibits apoptosis . May participate in the formation of the permeability transition pore complex (PTPC) responsible for the release of mitochondrial products that triggers apoptosis . May mediate ATP export from cells . .

AccessionsP21796
ENST00000425992.2
L8ECA2
ENST00000265333.8
ENST00000395044.7
ENST00000395047.6
C9JI87