NLGN2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0019233Biological processsensory perception of pain
GO_1902474Biological processpositive regulation of protein localization to synapse
GO_0001966Biological processthigmotaxis
GO_0097119Biological processpostsynaptic density protein 95 clustering
GO_0002087Biological processregulation of respiratory gaseous exchange by nervous system process
GO_0007630Biological processjump response
GO_0097104Biological processpostsynaptic membrane assembly
GO_0050804Biological processmodulation of chemical synaptic transmission
GO_1905606Biological processregulation of presynapse assembly
GO_0048488Biological processsynaptic vesicle endocytosis
GO_0050885Biological processneuromuscular process controlling balance
GO_2000809Biological processpositive regulation of synaptic vesicle clustering
GO_0034394Biological processprotein localization to cell surface
GO_0097116Biological processgephyrin clustering involved in postsynaptic density assembly
GO_0032024Biological processpositive regulation of insulin secretion
GO_2000463Biological processpositive regulation of excitatory postsynaptic potential
GO_1904862Biological processinhibitory synapse assembly
GO_0097151Biological processpositive regulation of inhibitory postsynaptic potential
GO_0007268Biological processchemical synaptic transmission
GO_0060999Biological processpositive regulation of dendritic spine development
GO_2000311Biological processregulation of AMPA receptor activity
GO_0099054Biological processpresynapse assembly
GO_1901142Biological processinsulin metabolic process
GO_1904034Biological processpositive regulation of t-SNARE clustering
GO_0072578Biological processneurotransmitter-gated ion channel clustering
GO_0072553Biological processterminal button organization
GO_0008284Biological processpositive regulation of cell population proliferation
GO_0051932Biological processsynaptic transmission, GABAergic
GO_0051968Biological processpositive regulation of synaptic transmission, glutamatergic
GO_0007416Biological processsynapse assembly
GO_0035418Biological processprotein localization to synapse
GO_0032230Biological processpositive regulation of synaptic transmission, GABAergic
GO_0098609Biological processcell-cell adhesion
GO_0007158Biological processneuron cell-cell adhesion
GO_0050808Biological processsynapse organization
GO_0035176Biological processsocial behavior
GO_0035641Biological processlocomotory exploration behavior
GO_0051965Biological processpositive regulation of synapse assembly
GO_0097105Biological processpresynaptic membrane assembly
GO_0045217Biological processcell-cell junction maintenance
GO_0098690Cellular componentglycinergic synapse
GO_0005886Cellular componentplasma membrane
GO_0016020Cellular componentmembrane
GO_0043198Cellular componentdendritic shaft
GO_0060077Cellular componentinhibitory synapse
GO_0098691Cellular componentdopaminergic synapse
GO_0042734Cellular componentpresynaptic membrane
GO_0097470Cellular componentribbon synapse
GO_0009986Cellular componentcell surface
GO_0045202Cellular componentsynapse
GO_0099634Cellular componentpostsynaptic specialization membrane
GO_0045211Cellular componentpostsynaptic membrane
GO_0060076Cellular componentexcitatory synapse
GO_0098983Cellular componentsymmetric, GABA-ergic, inhibitory synapse
GO_0038023Molecular functionsignaling receptor activity
GO_0042802Molecular functionidentical protein binding
GO_0042043Molecular functionneurexin family protein binding
GO_0050839Molecular functioncell adhesion molecule binding

IV. Literature review

[source]
Gene nameNLGN2
Protein nameNeuroligin-2
Neuroligin 2
SynonymsKIAA1366
DescriptionFUNCTION: Transmembrane scaffolding protein involved in cell-cell interactions via its interactions with neurexin family members. Mediates cell-cell interactions both in neurons and in other types of cells, such as Langerhans beta cells. Plays a role in synapse function and synaptic signal transmission, especially via gamma-aminobutyric acid receptors (GABA(A) receptors). Functions by recruiting and clustering synaptic proteins. Promotes clustering of postsynaptic GABRG2 and GPHN. Promotes clustering of postsynaptic LHFPL4 (By similarity). Modulates signaling by inhibitory synapses, and thereby plays a role in controlling the ratio of signaling by excitatory and inhibitory synapses and information processing. Required for normal signal amplitude from inhibitory synapses, but is not essential for normal signal frequency. May promote the initial formation of synapses, but is not essential for this. In vitro, triggers the de novo formation of presynaptic structures. Mediates cell-cell interactions between Langerhans beta cells and modulates insulin secretion (By similarity). .

AccessionsENST00000570940.1
Q8NFZ4
I3L498
ENST00000302926.7
ENST00000640620.2
ENST00000639647.1
ENST00000575301.5