Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| glutamatergic neuron | 7 studies | 34% ± 15% | |
| retinal cone cell | 6 studies | 43% ± 19% | |
| retinal rod cell | 6 studies | 24% ± 5% | |
| neuron | 4 studies | 21% ± 3% | |
| GABAergic neuron | 4 studies | 33% ± 9% | |
| interneuron | 3 studies | 31% ± 13% | |
| astrocyte | 3 studies | 21% ± 3% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| brain | 98% | 22339.10 | 2595 / 2642 | 100% | 41.43 | 703 / 705 |
| adrenal gland | 94% | 2855.68 | 243 / 258 | 98% | 27.21 | 226 / 230 |
| ovary | 99% | 4519.11 | 179 / 180 | 90% | 6.16 | 387 / 430 |
| prostate | 93% | 2767.51 | 228 / 245 | 77% | 3.45 | 386 / 502 |
| thymus | 62% | 1424.05 | 404 / 653 | 97% | 12.36 | 587 / 605 |
| lung | 80% | 2099.87 | 465 / 578 | 76% | 3.53 | 882 / 1155 |
| uterus | 98% | 4040.48 | 167 / 170 | 58% | 4.40 | 268 / 459 |
| bladder | 76% | 1874.76 | 16 / 21 | 66% | 3.47 | 333 / 504 |
| breast | 53% | 1198.07 | 242 / 459 | 90% | 5.48 | 1001 / 1118 |
| kidney | 38% | 928.71 | 34 / 89 | 76% | 3.81 | 687 / 901 |
| skin | 26% | 633.66 | 471 / 1809 | 82% | 6.39 | 387 / 472 |
| esophagus | 58% | 1473.99 | 837 / 1445 | 50% | 1.83 | 91 / 183 |
| intestine | 66% | 1875.24 | 635 / 966 | 42% | 1.83 | 220 / 527 |
| pancreas | 2% | 48.52 | 8 / 328 | 90% | 7.61 | 161 / 178 |
| spleen | 90% | 2358.66 | 216 / 241 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 88% | 6.75 | 70 / 80 |
| stomach | 33% | 896.12 | 117 / 359 | 53% | 2.02 | 153 / 286 |
| lymph node | 0% | 0 | 0 / 0 | 52% | 1.92 | 15 / 29 |
| heart | 48% | 1142.42 | 415 / 861 | 0% | 0 | 0 / 0 |
| adipose | 48% | 1145.97 | 573 / 1204 | 0% | 0 | 0 / 0 |
| blood vessel | 46% | 1046.92 | 619 / 1335 | 0% | 0 | 0 / 0 |
| liver | 1% | 27.74 | 3 / 226 | 22% | 0.88 | 90 / 406 |
| tonsil | 0% | 0 | 0 / 0 | 22% | 0.82 | 10 / 45 |
| peripheral blood | 10% | 206.54 | 95 / 929 | 0% | 0 | 0 / 0 |
| muscle | 1% | 14.37 | 7 / 803 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0016188 | Biological process | synaptic vesicle maturation |
| GO_0009790 | Biological process | embryo development |
| GO_0035865 | Biological process | cellular response to potassium ion |
| GO_0048169 | Biological process | regulation of long-term neuronal synaptic plasticity |
| GO_0007612 | Biological process | learning |
| GO_0045184 | Biological process | establishment of protein localization |
| GO_0007165 | Biological process | signal transduction |
| GO_0097113 | Biological process | AMPA glutamate receptor clustering |
| GO_0097120 | Biological process | receptor localization to synapse |
| GO_0050885 | Biological process | neuromuscular process controlling balance |
| GO_2000310 | Biological process | regulation of NMDA receptor activity |
| GO_2000463 | Biological process | positive regulation of excitatory postsynaptic potential |
| GO_0065003 | Biological process | protein-containing complex assembly |
| GO_0098970 | Biological process | postsynaptic neurotransmitter receptor diffusion trapping |
| GO_2000821 | Biological process | regulation of grooming behavior |
| GO_0045197 | Biological process | establishment or maintenance of epithelial cell apical/basal polarity |
| GO_0071625 | Biological process | vocalization behavior |
| GO_0150012 | Biological process | positive regulation of neuron projection arborization |
| GO_0007204 | Biological process | positive regulation of cytosolic calcium ion concentration |
| GO_0007268 | Biological process | chemical synaptic transmission |
| GO_0002091 | Biological process | negative regulation of receptor internalization |
| GO_0050806 | Biological process | positive regulation of synaptic transmission |
| GO_0035418 | Biological process | protein localization to synapse |
| GO_0098609 | Biological process | cell-cell adhesion |
| GO_0035176 | Biological process | social behavior |
| GO_0035641 | Biological process | locomotory exploration behavior |
| GO_0099645 | Biological process | neurotransmitter receptor localization to postsynaptic specialization membrane |
| GO_0007399 | Biological process | nervous system development |
| GO_0061098 | Biological process | positive regulation of protein tyrosine kinase activity |
| GO_0060997 | Biological process | dendritic spine morphogenesis |
| GO_0098978 | Cellular component | glutamatergic synapse |
| GO_0098839 | Cellular component | postsynaptic density membrane |
| GO_0005886 | Cellular component | plasma membrane |
| GO_0031594 | Cellular component | neuromuscular junction |
| GO_0043197 | Cellular component | dendritic spine |
| GO_0031234 | Cellular component | extrinsic component of cytoplasmic side of plasma membrane |
| GO_0030666 | Cellular component | endocytic vesicle membrane |
| GO_0097060 | Cellular component | synaptic membrane |
| GO_0044309 | Cellular component | neuron spine |
| GO_0032281 | Cellular component | AMPA glutamate receptor complex |
| GO_0043005 | Cellular component | neuron projection |
| GO_0030863 | Cellular component | cortical cytoskeleton |
| GO_0044300 | Cellular component | cerebellar mossy fiber |
| GO_0005783 | Cellular component | endoplasmic reticulum |
| GO_0005829 | Cellular component | cytosol |
| GO_0005912 | Cellular component | adherens junction |
| GO_0008021 | Cellular component | synaptic vesicle |
| GO_0045202 | Cellular component | synapse |
| GO_0014069 | Cellular component | postsynaptic density |
| GO_0044224 | Cellular component | juxtaparanode region of axon |
| GO_0005737 | Cellular component | cytoplasm |
| GO_0045211 | Cellular component | postsynaptic membrane |
| GO_0030054 | Cellular component | cell junction |
| GO_0060076 | Cellular component | excitatory synapse |
| GO_0032839 | Cellular component | dendrite cytoplasm |
| GO_0044306 | Cellular component | neuron projection terminus |
| GO_0008076 | Cellular component | voltage-gated potassium channel complex |
| GO_0016323 | Cellular component | basolateral plasma membrane |
| GO_0031812 | Molecular function | P2Y1 nucleotide receptor binding |
| GO_0031748 | Molecular function | D1 dopamine receptor binding |
| GO_0019903 | Molecular function | protein phosphatase binding |
| GO_0044877 | Molecular function | protein-containing complex binding |
| GO_0019900 | Molecular function | kinase binding |
| GO_0019901 | Molecular function | protein kinase binding |
| GO_0097109 | Molecular function | neuroligin family protein binding |
| GO_0030165 | Molecular function | PDZ domain binding |
| GO_0097110 | Molecular function | scaffold protein binding |
| GO_0031697 | Molecular function | beta-1 adrenergic receptor binding |
| GO_0035255 | Molecular function | ionotropic glutamate receptor binding |
| GO_0033130 | Molecular function | acetylcholine receptor binding |
| GO_0005515 | Molecular function | protein binding |
| Gene name | DLG4 |
| Protein name | DLG4 protein Discs large MAGUK scaffold protein 4 (Discs, large homolog 4 (Drosophila), isoform CRA_d) (Tax interaction protein 15) Discs large MAGUK scaffold protein 4 (Discs, large homolog 4 (Drosophila), isoform CRA_b) (cDNA FLJ50646, highly similar to Discs large homolog 4) (cDNA, FLJ78995, highly similar to Discs large homolog 4) Disks large homolog 4 (Postsynaptic density protein 95) (PSD-95) (Synapse-associated protein 90) (SAP-90) (SAP90) Discs large MAGUK scaffold protein 4 Discs large MAGUK scaffold protein 4 (cDNA FLJ60612, highly similar to Discs large homolog 4) DLG4 protein (Discs large MAGUK scaffold protein 4) (Discs, large homolog 4 (Drosophila), isoform CRA_c) |
| Synonyms | hCG_40530 PSD95 |
| Description | FUNCTION: Postsynaptic scaffolding protein that plays a critical role in synaptogenesis and synaptic plasticity by providing a platform for the postsynaptic clustering of crucial synaptic proteins. Interacts with the cytoplasmic tail of NMDA receptor subunits and shaker-type potassium channels. Required for synaptic plasticity associated with NMDA receptor signaling. Overexpression or depletion of DLG4 changes the ratio of excitatory to inhibitory synapses in hippocampal neurons. May reduce the amplitude of ASIC3 acid-evoked currents by retaining the channel intracellularly. May regulate the intracellular trafficking of ADR1B. Also regulates AMPA-type glutamate receptor (AMPAR) immobilization at postsynaptic density keeping the channels in an activated state in the presence of glutamate and preventing synaptic depression (By similarity). Under basal conditions, cooperates with FYN to stabilize palmitoyltransferase ZDHHC5 at the synaptic membrane through FYN-mediated phosphorylation of ZDHHC5 and its subsequent inhibition of association with endocytic proteins . . |
| Accessions | Q3ZCU5 ENST00000647975.1 C9JYG3 ENST00000399506.9 [P78352-1] ENST00000648896.1 ENST00000491753.2 ENST00000650301.1 A0A3B3ISR0 A0A3B3IRP2 B7Z3U2 K7EKP9 ENST00000493294.2 ENST00000649520.1 ENST00000648760.1 ENST00000648263.1 B9EGL1 ENST00000485100.5 ENST00000649971.1 A0A3B3IS17 B7Z647 ENST00000648172.8 [P78352-2] ENST00000650120.1 A0A3B3ITD1 ENST00000451807.7 ENST00000649186.1 C9JWP9 O14909 A0A3B3ISL1 P78352 ENST00000302955.11 [P78352-3] ENST00000486626.8 ENST00000648658.1 A0A3B3ISQ5 ENST00000399510.8 A0A3B3IU19 K7EKU8 ENST00000447163.6 A0A3B3ITI9 |
