DOC2B | OmnibusX

Name	Number of supported studies	Average coverage
retinal cone cell	6 studies	25% ± 8%	Explore
Mueller cell	5 studies	20% ± 2%	Explore
endothelial cell	4 studies	22% ± 4%	Explore
endothelial cell of lymphatic vessel	3 studies	24% ± 4%	Explore
retinal rod cell	3 studies	24% ± 6%	Explore
vein endothelial cell	3 studies	30% ± 15%	Explore
endothelial cell of vascular tree	3 studies	21% ± 3%	Explore

Name	Number of supported studies	Average coverage
eye	3 studies	19% ± 2%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	93%	2393.89	1339 / 1445	83%	18.71	152 / 183
brain	97%	6459.75	2560 / 2642	71%	8.32	501 / 705
pancreas	86%	1708.74	283 / 328	76%	7.30	135 / 178
breast	99%	4369.99	456 / 459	61%	6.96	686 / 1118
uterus	88%	1510.32	150 / 170	72%	16.11	330 / 459
adrenal gland	69%	872.99	179 / 258	82%	38.78	188 / 230
lung	82%	1001.42	473 / 578	69%	10.46	796 / 1155
kidney	96%	1837.40	85 / 89	51%	5.17	462 / 901
prostate	79%	1097.69	193 / 245	53%	3.18	267 / 502
intestine	84%	1205.79	814 / 966	46%	5.73	241 / 527
bladder	86%	1304.86	18 / 21	41%	4.39	208 / 504
stomach	57%	732.74	203 / 359	59%	8.94	169 / 286
thymus	76%	911.12	498 / 653	28%	1.72	168 / 605
adipose	100%	4731.84	1202 / 1204	0%	0	0 / 0
tonsil	0%	0	0 / 0	93%	57.57	42 / 45
spleen	86%	960.36	207 / 241	0%	0	0 / 0
ovary	13%	197.26	23 / 180	68%	15.02	291 / 430
skin	60%	902.65	1082 / 1809	19%	1.28	91 / 472
heart	52%	561.72	450 / 861	0%	0	0 / 0
lymph node	0%	0	0 / 0	52%	3.62	15 / 29
blood vessel	41%	603.93	545 / 1335	0%	0	0 / 0
muscle	29%	277.67	232 / 803	0%	0	0 / 0
liver	3%	29.79	6 / 226	14%	0.83	56 / 406
eye	0%	0	0 / 0	16%	2.42	13 / 80
peripheral blood	1%	12.92	13 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

GO_0017158	Biological process	regulation of calcium ion-dependent exocytosis
GO_0045956	Biological process	positive regulation of calcium ion-dependent exocytosis
GO_0008104	Biological process	protein localization
GO_0048791	Biological process	calcium ion-regulated exocytosis of neurotransmitter
GO_0006887	Biological process	exocytosis
GO_0031340	Biological process	positive regulation of vesicle fusion
GO_0099502	Biological process	calcium-dependent activation of synaptic vesicle fusion
GO_0061669	Biological process	spontaneous neurotransmitter secretion
GO_0032024	Biological process	positive regulation of insulin secretion
GO_0098793	Cellular component	presynapse
GO_0045202	Cellular component	synapse
GO_0005886	Cellular component	plasma membrane
GO_0031201	Cellular component	SNARE complex
GO_0005737	Cellular component	cytoplasm
GO_0005509	Molecular function	calcium ion binding
GO_0005544	Molecular function	calcium-dependent phospholipid binding
GO_0019905	Molecular function	syntaxin binding

Gene name	DOC2B
Protein name	Double C2 domain beta Double C2-like domain-containing protein beta (Doc2-beta) Double C2-like domain-containing protein
Synonyms	DOC2BL
Description	FUNCTION: Calcium sensor which positively regulates SNARE-dependent fusion of vesicles with membranes. Binds phospholipids in a calcium-dependent manner and may act at the priming stage of fusion by modifying membrane curvature to stimulate fusion. Involved in calcium-triggered exocytosis in chromaffin cells and calcium-dependent spontaneous release of neurotransmitter in absence of action potentials in neuronal cells. Involved both in glucose-stimulated insulin secretion in pancreatic cells and insulin-dependent GLUT4 transport to the plasma membrane in adipocytes (By similarity). .
Accessions	A0A0G2JKH4 ENST00000697390.1 A0A8V8TML1 ENST00000613549.3 ENST00000496357.4 Q14184

DOC2B report