RGS10 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
macrophage	38 studies	52% ± 21%	Explore
CD8-positive, alpha-beta T cell	32 studies	42% ± 19%	Explore
conventional dendritic cell	31 studies	66% ± 18%	Explore
CD4-positive, alpha-beta T cell	31 studies	47% ± 18%	Explore
T cell	29 studies	37% ± 15%	Explore
dendritic cell	27 studies	51% ± 24%	Explore
regulatory T cell	27 studies	45% ± 16%	Explore
classical monocyte	24 studies	38% ± 13%	Explore
non-classical monocyte	23 studies	40% ± 15%	Explore
mast cell	19 studies	46% ± 14%	Explore
monocyte	18 studies	43% ± 15%	Explore
plasmacytoid dendritic cell	18 studies	33% ± 11%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	16 studies	52% ± 12%	Explore
microglial cell	16 studies	48% ± 21%	Explore
B cell	15 studies	26% ± 11%	Explore
gamma-delta T cell	15 studies	36% ± 16%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	14 studies	57% ± 16%	Explore
CD8-positive, alpha-beta memory T cell	12 studies	40% ± 20%	Explore
mature NK T cell	12 studies	27% ± 11%	Explore
platelet	11 studies	70% ± 22%	Explore
fibroblast	11 studies	32% ± 13%	Explore
myeloid cell	11 studies	53% ± 17%	Explore
natural killer cell	10 studies	24% ± 8%	Explore
memory B cell	10 studies	21% ± 5%	Explore
CD4-positive, alpha-beta memory T cell	10 studies	46% ± 15%	Explore
mucosal invariant T cell	10 studies	29% ± 5%	Explore
leukocyte	9 studies	47% ± 15%	Explore
effector memory CD8-positive, alpha-beta T cell	8 studies	37% ± 12%	Explore
T follicular helper cell	8 studies	50% ± 8%	Explore
erythrocyte	8 studies	37% ± 22%	Explore
effector CD8-positive, alpha-beta T cell	7 studies	38% ± 17%	Explore
hematopoietic stem cell	7 studies	37% ± 23%	Explore
CD4-positive helper T cell	6 studies	28% ± 8%	Explore
effector CD4-positive, alpha-beta T cell	6 studies	56% ± 23%	Explore
mononuclear phagocyte	6 studies	56% ± 25%	Explore
megakaryocyte	6 studies	82% ± 14%	Explore
effector memory CD4-positive, alpha-beta T cell	6 studies	44% ± 16%	Explore
connective tissue cell	6 studies	37% ± 16%	Explore
alveolar macrophage	5 studies	30% ± 4%	Explore
exhausted T cell	5 studies	51% ± 16%	Explore
CD16-negative, CD56-bright natural killer cell, human	5 studies	20% ± 3%	Explore
innate lymphoid cell	5 studies	32% ± 15%	Explore
myofibroblast cell	4 studies	49% ± 15%	Explore
plasma cell	4 studies	29% ± 10%	Explore
abnormal cell	4 studies	29% ± 8%	Explore
intermediate monocyte	4 studies	53% ± 18%	Explore
granulocyte	4 studies	36% ± 17%	Explore
basal cell	4 studies	24% ± 10%	Explore
T-helper 17 cell	4 studies	42% ± 7%	Explore
double negative thymocyte	4 studies	48% ± 18%	Explore
hematopoietic precursor cell	3 studies	45% ± 9%	Explore
Langerhans cell	3 studies	61% ± 23%	Explore
monocyte-derived dendritic cell	3 studies	66% ± 27%	Explore
naive B cell	3 studies	25% ± 12%	Explore
erythroblast	3 studies	43% ± 32%	Explore
pericyte	3 studies	24% ± 4%	Explore
smooth muscle cell	3 studies	42% ± 5%	Explore
thymocyte	3 studies	28% ± 16%	Explore
tissue-resident macrophage	3 studies	48% ± 23%	Explore
intraepithelial lymphocyte	3 studies	46% ± 24%	Explore
germinal center B cell	3 studies	44% ± 3%	Explore
plasmablast	3 studies	26% ± 14%	Explore
megakaryocyte-erythroid progenitor cell	3 studies	47% ± 20%	Explore
group 3 innate lymphoid cell	3 studies	30% ± 14%	Explore
goblet cell	3 studies	31% ± 11%	Explore
T-helper 1 cell	3 studies	54% ± 9%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	3 studies	29% ± 6%	Explore
central memory CD4-positive, alpha-beta T cell	3 studies	46% ± 12%	Explore
central memory CD8-positive, alpha-beta T cell	3 studies	38% ± 12%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
peripheral blood	18 studies	35% ± 9%	Explore
intestine	8 studies	29% ± 11%	Explore
lung	7 studies	28% ± 8%	Explore
lymph node	6 studies	33% ± 13%	Explore
bone marrow	5 studies	21% ± 6%	Explore
liver	5 studies	36% ± 24%	Explore
kidney	3 studies	32% ± 11%	Explore
uterus	3 studies	32% ± 16%	Explore
brain	3 studies	39% ± 21%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
prostate	100%	1421.27	245 / 245	100%	225.34	502 / 502
ovary	99%	683.31	178 / 180	99%	129.82	426 / 430
breast	98%	788.42	452 / 459	99%	118.15	1112 / 1118
uterus	100%	1184.86	170 / 170	97%	87.69	446 / 459
lung	99%	901.76	575 / 578	96%	66.74	1110 / 1155
esophagus	100%	1136.61	1444 / 1445	95%	44.61	174 / 183
skin	99%	1167.57	1794 / 1809	95%	96.65	450 / 472
bladder	100%	1143.33	21 / 21	90%	60.83	455 / 504
thymus	100%	1107.30	651 / 653	90%	100.02	547 / 605
intestine	100%	2658.73	966 / 966	89%	44.70	470 / 527
stomach	98%	768.94	353 / 359	87%	45.25	250 / 286
kidney	94%	492.74	84 / 89	81%	46.41	733 / 901
brain	61%	399.16	1622 / 2642	94%	80.02	660 / 705
adrenal gland	66%	247.94	171 / 258	44%	15.41	101 / 230
pancreas	13%	46.84	42 / 328	94%	61.07	168 / 178
lymph node	0%	0	0 / 0	100%	325.05	29 / 29
peripheral blood	100%	2710.29	929 / 929	0%	0	0 / 0
spleen	100%	1292.70	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	90.90	45 / 45
ureter	0%	0	0 / 0	100%	79.90	1 / 1
adipose	98%	733.82	1185 / 1204	0%	0	0 / 0
blood vessel	96%	733.02	1279 / 1335	0%	0	0 / 0
eye	0%	0	0 / 0	91%	49.93	73 / 80
muscle	78%	557.43	623 / 803	0%	0	0 / 0
heart	49%	174.29	421 / 861	0%	0	0 / 0
liver	3%	9.63	6 / 226	31%	11.89	125 / 406
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0007186	Biological process	G protein-coupled receptor signaling pathway
GO_0008277	Biological process	regulation of G protein-coupled receptor signaling pathway
GO_0007213	Biological process	G protein-coupled acetylcholine receptor signaling pathway
GO_0043547	Biological process	positive regulation of GTPase activity
GO_0009968	Biological process	negative regulation of signal transduction
GO_0016604	Cellular component	nuclear body
GO_0005654	Cellular component	nucleoplasm
GO_0005829	Cellular component	cytosol
GO_0045202	Cellular component	synapse
GO_0005886	Cellular component	plasma membrane
GO_0005634	Cellular component	nucleus
GO_0001965	Molecular function	G-protein alpha-subunit binding
GO_0005515	Molecular function	protein binding
GO_0005096	Molecular function	GTPase activator activity
GO_0003924	Molecular function	GTPase activity

IV. Literature review

[source]

Gene name	RGS10
Protein name	Regulator of G-protein signaling 10 (RGS10)
Synonyms
Description	FUNCTION: Regulates G protein-coupled receptor signaling cascades, including signaling downstream of the muscarinic acetylcholine receptor CHRM2. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form . Modulates the activity of potassium channels that are activated in response to CHRM2 signaling . Activity on GNAZ is inhibited by palmitoylation of the G-protein . .
Accessions	ENST00000369101.7 [O43665-1] ENST00000392865.5 [O43665-2] ENST00000369103.3 [O43665-3] O43665

RGS10 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review