NR1I2 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of NR1I2 at tissue level.

III. Associated gene sets

GO_0006805Biological processxenobiotic metabolic process
GO_0007165Biological processsignal transduction
GO_0010628Biological processpositive regulation of gene expression
GO_0030522Biological processintracellular receptor signaling pathway
GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_0042908Biological processxenobiotic transport
GO_0042178Biological processxenobiotic catabolic process
GO_0045893Biological processpositive regulation of DNA-templated transcription
GO_0030154Biological processcell differentiation
GO_0006355Biological processregulation of DNA-templated transcription
GO_0008202Biological processsteroid metabolic process
GO_0045892Biological processnegative regulation of DNA-templated transcription
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0005654Cellular componentnucleoplasm
GO_0045111Cellular componentintermediate filament cytoskeleton
GO_0016604Cellular componentnuclear body
GO_0000785Cellular componentchromatin
GO_0005667Cellular componenttranscription regulator complex
GO_0005634Cellular componentnucleus
GO_0000978Molecular functionRNA polymerase II cis-regulatory region sequence-specific DNA binding
GO_0016922Molecular functionnuclear receptor binding
GO_0001228Molecular functionDNA-binding transcription activator activity, RNA polymerase II-specific
GO_0000977Molecular functionRNA polymerase II transcription regulatory region sequence-specific DNA binding
GO_0000981Molecular functionDNA-binding transcription factor activity, RNA polymerase II-specific
GO_0004879Molecular functionnuclear receptor activity
GO_1990837Molecular functionsequence-specific double-stranded DNA binding
GO_0008270Molecular functionzinc ion binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameNR1I2
Protein nameNuclear receptor subfamily 1 group I member 2 (Orphan nuclear receptor PAR1) (Orphan nuclear receptor PXR) (Pregnane X receptor) (Steroid and xenobiotic receptor) (SXR)
Nuclear receptor subfamily 1 group I member 2 (Nuclear receptor subfamily 1, group I, member 2, isoform CRA_c)
Orphan nuclear receptor PXR
Nuclear receptor subfamily 1 group I member 2 (Nuclear receptor subfamily 1, group I, member 2, isoform CRA_a)
Pregnane X nuclear receptor
Nuclear receptor subfamily 1, group I, member 2, isoform CRA_b (Pregnane X nuclear receptor variant 2)
PAR2
SynonymsNR1i2
hCG_21777
PXR
DescriptionFUNCTION: Nuclear receptor that binds and is activated by variety of endogenous and xenobiotic compounds. Transcription factor that activates the transcription of multiple genes involved in the metabolism and secretion of potentially harmful xenobiotics, drugs and endogenous compounds. Activated by the antibiotic rifampicin and various plant metabolites, such as hyperforin, guggulipid, colupulone, and isoflavones. Response to specific ligands is species-specific. Activated by naturally occurring steroids, such as pregnenolone and progesterone. Binds to a response element in the promoters of the CYP3A4 and ABCB1/MDR1 genes. .

AccessionsENST00000337940.4 [O75469-7]
J3KPQ3
O75469
ENST00000466380
ENST00000393716.8 [O75469-1]
H0Y8E2
Q9H4M8
ENST00000393716
ENST00000466380.6 [O75469-4]
B6ZGT1
F1DAL3
F1D8P9