NR2C1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0048386Biological processpositive regulation of retinoic acid receptor signaling pathway
GO_0030522Biological processintracellular receptor signaling pathway
GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_0030154Biological processcell differentiation
GO_0043401Biological processsteroid hormone receptor signaling pathway
GO_0048856Biological processanatomical structure development
GO_0005654Cellular componentnucleoplasm
GO_0016605Cellular componentPML body
GO_0000785Cellular componentchromatin
GO_0003677Molecular functionDNA binding
GO_0042803Molecular functionprotein homodimerization activity
GO_0000978Molecular functionRNA polymerase II cis-regulatory region sequence-specific DNA binding
GO_0038023Molecular functionsignaling receptor activity
GO_0001227Molecular functionDNA-binding transcription repressor activity, RNA polymerase II-specific
GO_0000981Molecular functionDNA-binding transcription factor activity, RNA polymerase II-specific
GO_0003707Molecular functionnuclear steroid receptor activity
GO_0004879Molecular functionnuclear receptor activity
GO_1990837Molecular functionsequence-specific double-stranded DNA binding
GO_0008270Molecular functionzinc ion binding
GO_0005515Molecular functionprotein binding
GO_0042826Molecular functionhistone deacetylase binding

IV. Literature review

[source]
Gene nameNR2C1
Protein nameNuclear receptor subfamily 2 group C member 1
Nuclear receptor subfamily 2 group C member 1 (Orphan nuclear receptor TR2) (Testicular receptor 2)
Nuclear receptor subfamily 2, group C isoform
SynonymshCG_18174
TR2
DescriptionFUNCTION: Orphan nuclear receptor. Binds the IR7 element in the promoter of its own gene in an autoregulatory negative feedback mechanism. Primarily repressor of a broad range of genes. Binds to hormone response elements (HREs) consisting of two 5'-AGGTCA-3' half site direct repeat consensus sequences. Together with NR2C2, forms the core of the DRED (direct repeat erythroid-definitive) complex that represses embryonic and fetal globin transcription. Also activator of OCT4 gene expression. May be involved in stem cell proliferation and differentiation. Mediator of retinoic acid-regulated preadipocyte proliferation. .

AccessionsENST00000393101.7 [P13056-2]
P13056
H0YIV1
ENST00000622476.4
H0YHC6
ENST00000551647.5
ENST00000333003.10 [P13056-1]
B6ZGT7
H9NIM2
ENST00000547469.1
ENST00000330677.7 [P13056-3]
ENST00000552791.1
A0A087WUK4
F8W1Q1