NR4A1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0071376Biological processcellular response to corticotropin-releasing hormone stimulus
GO_0006366Biological processtranscription by RNA polymerase II
GO_0061469Biological processregulation of type B pancreatic cell proliferation
GO_0006954Biological processinflammatory response
GO_0045786Biological processnegative regulation of cell cycle
GO_0051602Biological processresponse to electrical stimulus
GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_0007165Biological processsignal transduction
GO_0002042Biological processcell migration involved in sprouting angiogenesis
GO_0030522Biological processintracellular receptor signaling pathway
GO_0035767Biological processendothelial cell chemotaxis
GO_0001938Biological processpositive regulation of endothelial cell proliferation
GO_0160075Biological processnon-canonical inflammasome complex assembly
GO_0006915Biological processapoptotic process
GO_0001975Biological processresponse to amphetamine
GO_0035914Biological processskeletal muscle cell differentiation
GO_0014860Biological processneurotransmitter secretion involved in regulation of skeletal muscle contraction
GO_0032497Biological processdetection of lipopolysaccharide
GO_0043065Biological processpositive regulation of apoptotic process
GO_0035924Biological processcellular response to vascular endothelial growth factor stimulus
GO_0044344Biological processcellular response to fibroblast growth factor stimulus
GO_0045444Biological processfat cell differentiation
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0098793Cellular componentpresynapse
GO_0005739Cellular componentmitochondrion
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0000785Cellular componentchromatin
GO_0031965Cellular componentnuclear membrane
GO_0005667Cellular componenttranscription regulator complex
GO_0005634Cellular componentnucleus
GO_0003677Molecular functionDNA binding
GO_0000978Molecular functionRNA polymerase II cis-regulatory region sequence-specific DNA binding
GO_0035259Molecular functionnuclear glucocorticoid receptor binding
GO_0001228Molecular functionDNA-binding transcription activator activity, RNA polymerase II-specific
GO_0000981Molecular functionDNA-binding transcription factor activity, RNA polymerase II-specific
GO_0004879Molecular functionnuclear receptor activity
GO_1990837Molecular functionsequence-specific double-stranded DNA binding
GO_0042802Molecular functionidentical protein binding
GO_0008270Molecular functionzinc ion binding
GO_0046982Molecular functionprotein heterodimerization activity
GO_0001530Molecular functionlipopolysaccharide binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameNR4A1
Protein nameNuclear receptor subfamily 4 group A member 1
Nuclear receptor subfamily 4immunitygroup A member 1 (Early response protein NAK1) (Nuclear hormone receptor NUR/77) (Nur77) (Orphan nuclear receptor HMR) (Orphan nuclear receptor TR3) (ST-59) (Testicular receptor 3)
SynonymsHMR
NAK1
GFRP1
DescriptionFUNCTION: Orphan nuclear receptor. Binds the NGFI-B response element (NBRE) 5'-AAAGGTCA-3' . Binds 9-cis-retinoic acid outside of its ligand-binding (NR LBD) domain . Participates in energy homeostasis by sequestrating the kinase STK11 in the nucleus, thereby attenuating cytoplasmic AMPK activation . Regulates the inflammatory response in macrophages by regulating metabolic adaptations during inflammation, including repressing the transcription of genes involved in the citric acid cycle (TCA) (By similarity). Inhibits NF-kappa-B signaling by binding to low-affinity NF-kappa-B binding sites, such as at the IL2 promoter . May act concomitantly with NR4A2 in regulating the expression of delayed-early genes during liver regeneration (By similarity). Plays a role in the vascular response to injury (By similarity). .; FUNCTION: In the cytosol, upon its detection of both bacterial lipopolysaccharide (LPS) and NBRE-containing mitochondrial DNA released by GSDMD pores during pyroptosis, it promotes non-canonical NLRP3 inflammasome activation by stimulating association of NLRP3 and NEK7. .

FUNCTION: In the cytosol, upon its detection of both bacterial lipopolysaccharide (LPS) and NBRE-containing mitochondrial DNA released by GSDMD pores during pyroptosis, it promotes non-canonical NLRP3 inflammasome activation by stimulating association of NLRP3 and NEK7. .

AccessionsENST00000546842.5
ENST00000360284.7 [P22736-2]
H3BT85
ENST00000545748.5
ENST00000243050.5 [P22736-1]
ENST00000548232.1 [P22736-3]
H3BQG5
ENST00000394825.6 [P22736-1]
ENST00000548977.5
ENST00000562373.1
ENST00000550082.5 [P22736-2]
ENST00000550582.2
H3BSM8
ENST00000550763.1
ENST00000553200.1
F5GXF0
P22736
F8VVX9
H3BSB9
H3BPN8
ENST00000394824.2 [P22736-1]