NR1H3 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of NR1H3 at tissue level.

III. Associated gene sets

GO_0055092Biological processsterol homeostasis
GO_0070328Biological processtriglyceride homeostasis
GO_0043031Biological processnegative regulation of macrophage activation
GO_0036151Biological processphosphatidylcholine acyl-chain remodeling
GO_0051247Biological processpositive regulation of protein metabolic process
GO_0010887Biological processnegative regulation of cholesterol storage
GO_0045723Biological processpositive regulation of fatty acid biosynthetic process
GO_0090341Biological processnegative regulation of secretion of lysosomal enzymes
GO_0030522Biological processintracellular receptor signaling pathway
GO_0060336Biological processnegative regulation of type II interferon-mediated signaling pathway
GO_0046889Biological processpositive regulation of lipid biosynthetic process
GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_0010867Biological processpositive regulation of triglyceride biosynthetic process
GO_1903573Biological processnegative regulation of response to endoplasmic reticulum stress
GO_0042752Biological processregulation of circadian rhythm
GO_0042632Biological processcholesterol homeostasis
GO_0032376Biological processpositive regulation of cholesterol transport
GO_0048550Biological processnegative regulation of pinocytosis
GO_0010745Biological processnegative regulation of macrophage derived foam cell differentiation
GO_0032369Biological processnegative regulation of lipid transport
GO_0043277Biological processapoptotic cell clearance
GO_0050728Biological processnegative regulation of inflammatory response
GO_0045861Biological processnegative regulation of proteolysis
GO_0045893Biological processpositive regulation of DNA-templated transcription
GO_0034145Biological processpositive regulation of toll-like receptor 4 signaling pathway
GO_0030154Biological processcell differentiation
GO_0010875Biological processpositive regulation of cholesterol efflux
GO_0009755Biological processhormone-mediated signaling pathway
GO_0042789Biological processmRNA transcription by RNA polymerase II
GO_0071222Biological processcellular response to lipopolysaccharide
GO_0051006Biological processpositive regulation of lipoprotein lipase activity
GO_0032411Biological processpositive regulation of transporter activity
GO_0090188Biological processnegative regulation of pancreatic juice secretion
GO_0055088Biological processlipid homeostasis
GO_0032570Biological processresponse to progesterone
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0120163Biological processnegative regulation of cold-induced thermogenesis
GO_0043235Cellular componentreceptor complex
GO_0005654Cellular componentnucleoplasm
GO_0090575Cellular componentRNA polymerase II transcription regulator complex
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0000785Cellular componentchromatin
GO_0005634Cellular componentnucleus
GO_0003677Molecular functionDNA binding
GO_0000978Molecular functionRNA polymerase II cis-regulatory region sequence-specific DNA binding
GO_0001228Molecular functionDNA-binding transcription activator activity, RNA polymerase II-specific
GO_0015485Molecular functioncholesterol binding
GO_0000981Molecular functionDNA-binding transcription factor activity, RNA polymerase II-specific
GO_0000976Molecular functiontranscription cis-regulatory region binding
GO_0004879Molecular functionnuclear receptor activity
GO_0032810Molecular functionsterol response element binding
GO_0008270Molecular functionzinc ion binding
GO_0031490Molecular functionchromatin DNA binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameNR1H3
Protein nameNuclear receptor subfamily 1 group H member 3
Liver X nuclear receptor alpha variant 1
Liver X receptor alpha
Nuclear receptor subfamily 1 group H member 3 (cDNA FLJ56172, highly similar to Oxysterols receptor LXR-alpha)
Oxysterols receptor LXR-alpha (Liver X receptor alpha) (Nuclear receptor subfamily 1 group H member 3)
SynonymsLXRA
DescriptionFUNCTION: Nuclear receptor that exhibits a ligand-dependent transcriptional activation activity . Interaction with retinoic acid receptor (RXR) shifts RXR from its role as a silent DNA-binding partner to an active ligand-binding subunit in mediating retinoid responses through target genes defined by LXRES (By similarity). LXRES are DR4-type response elements characterized by direct repeats of two similar hexanuclotide half-sites spaced by four nucleotides (By similarity). Plays an important role in the regulation of cholesterol homeostasis, regulating cholesterol uptake through MYLIP-dependent ubiquitination of LDLR, VLDLR and LRP8 . Interplays functionally with RORA for the regulation of genes involved in liver metabolism (By similarity). Induces LPCAT3-dependent phospholipid remodeling in endoplasmic reticulum (ER) membranes of hepatocytes, driving SREBF1 processing and lipogenesis (By similarity). Via LPCAT3, triggers the incorporation of arachidonate into phosphatidylcholines of ER membranes, increasing membrane dynamics and enabling triacylglycerols transfer to nascent very low-density lipoprotein (VLDL) particles. Via LPCAT3 also counteracts lipid-induced ER stress response and inflammation, likely by modulating SRC kinase membrane compartmentalization and limiting the synthesis of lipid inflammatory mediators (By similarity). .

AccessionsC9J2C8
C9JTS4
C9JEC2
C9JJ16
E9PLL4
F8WC63
ENST00000407404.5 [Q13133-2]
ENST00000412937.5
ENST00000481889.6
ENST00000405853.7 [Q13133-2]
ENST00000395397.7 [Q13133-3]
E9PID2
Q13133
ENST00000420369.5
ENST00000441012.7 [Q13133-1]
ENST00000405576.5
ENST00000457932.5
ENST00000444396.5
C9J4R0
ENST00000616973.4
ENST00000436029.5
F1D8N1
B6ZGS8
ENST00000467728.5 [Q13133-1]
ENST00000437276.1
ENST00000527949.1
ENST00000531660.5
C9JBS2
E9PPA1
ENST00000419652.5
B5MBY7
ENST00000449369.5
C9JCS0
F8WEY6
B4DXU5
ENST00000436778.5