NR3C2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_1901224Biological processpositive regulation of non-canonical NF-kappaB signal transduction
GO_0030518Biological processnuclear receptor-mediated steroid hormone signaling pathway
GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_0007165Biological processsignal transduction
GO_0043235Cellular componentreceptor complex
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0000785Cellular componentchromatin
GO_0005634Cellular componentnucleus
GO_0017025Molecular functionTBP-class protein binding
GO_0000981Molecular functionDNA-binding transcription factor activity, RNA polymerase II-specific
GO_0003707Molecular functionnuclear steroid receptor activity
GO_0004879Molecular functionnuclear receptor activity
GO_1990837Molecular functionsequence-specific double-stranded DNA binding
GO_0034056Molecular functionestrogen response element binding
GO_0003700Molecular functionDNA-binding transcription factor activity
GO_0008270Molecular functionzinc ion binding
GO_0005496Molecular functionsteroid binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameNR3C2
Protein nameMineralocorticoid receptor 3 (Nuclear receptor subfamily 3, group C, member 2 variant 4)
Uncharacterized protein NR3C2
Mineralocorticoid receptor (Nuclear receptor subfamily 3 group C member 2)
Mineralocorticoid receptor (MR) (Nuclear receptor subfamily 3 group C member 2)
SynonymsMCR
MLR
DescriptionFUNCTION: Receptor for both mineralocorticoids (MC) such as aldosterone and glucocorticoids (GC) such as corticosterone or cortisol. Binds to mineralocorticoid response elements (MRE) and transactivates target genes. The effect of MC is to increase ion and water transport and thus raise extracellular fluid volume and blood pressure and lower potassium levels. .

FUNCTION: Receptor for both mineralocorticoids (MC) such as aldosterone and glucocorticoids (GC) such as corticosterone or cortisol. Binds to mineralocorticoid response elements (MRE) and transactivates target genes. The effect of MC is to increase ion and water transport and thus raise extracellular fluid volume and blood pressure and lower potassium levels. .

AccessionsB0ZBF6
ENST00000625323.2 [P08235-3]
B0ZBF8
P08235
ENST00000344721.8 [P08235-1]
ENST00000512865.5 [P08235-4]
Q4W5E8
ENST00000342437.8 [P08235-2]
ENST00000358102.8 [P08235-1]
ENST00000511528.1 [P08235-3]