NR2F6 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0030522Biological processintracellular receptor signaling pathway
GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_0050965Biological processdetection of temperature stimulus involved in sensory perception of pain
GO_0030154Biological processcell differentiation
GO_0048666Biological processneuron development
GO_0043153Biological processentrainment of circadian clock by photoperiod
GO_0048856Biological processanatomical structure development
GO_0005654Cellular componentnucleoplasm
GO_0000785Cellular componentchromatin
GO_0005634Cellular componentnucleus
GO_0000978Molecular functionRNA polymerase II cis-regulatory region sequence-specific DNA binding
GO_0001227Molecular functionDNA-binding transcription repressor activity, RNA polymerase II-specific
GO_0000981Molecular functionDNA-binding transcription factor activity, RNA polymerase II-specific
GO_0043565Molecular functionsequence-specific DNA binding
GO_0004879Molecular functionnuclear receptor activity
GO_1990837Molecular functionsequence-specific double-stranded DNA binding
GO_0003700Molecular functionDNA-binding transcription factor activity
GO_0008270Molecular functionzinc ion binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameNR2F6
Protein nameNuclear receptor subfamily 2 group F member 6
Nuclear receptor subfamily 2, group F, member 6
Nuclear receptor subfamily 2 group F member 6 (V-erbA-related protein 2) (EAR-2)
Nuclear receptor V-erbA-related
SynonymsEAR2
ERBAL2
DescriptionFUNCTION: Transcription factor predominantly involved in transcriptional repression. Binds to promoter/enhancer response elements that contain the imperfect 5'-AGGTCA-3' direct or inverted repeats with various spacings which are also recognized by other nuclear hormone receptors. Involved in modulation of hormonal responses. Represses transcriptional activity of the lutropin-choriogonadotropic hormone receptor/LHCGR gene, the renin/REN gene and the oxytocin-neurophysin/OXT gene. Represses the triiodothyronine-dependent and -independent transcriptional activity of the thyroid hormone receptor gene in a cell type-specific manner. The corepressing function towards thyroid hormone receptor beta/THRB involves at least in part the inhibition of THRB binding to triiodothyronine response elements (TREs) by NR2F6. Inhibits NFATC transcription factor DNA binding and subsequently its transcriptional activity. Acts as transcriptional repressor of IL-17 expression in Th-17 differentiated CD4(+) T cells and may be involved in induction and/or maintenance of peripheral immunological tolerance and autoimmunity. Involved in development of forebrain circadian clock; is required early in the development of the locus coeruleus (LC). .

AccessionsENST00000596878.1
ENST00000291442.4
M0R175
P10588
B6ZGU2
F1D8R3