RARA report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of RARA at tissue level.

III. Associated gene sets

GO_1901532Biological processregulation of hematopoietic progenitor cell differentiation
GO_0035264Biological processmulticellular organism growth
GO_0030850Biological processprostate gland development
GO_0060534Biological processtrachea cartilage development
GO_0042789Biological processmRNA transcription by RNA polymerase II
GO_0032689Biological processnegative regulation of type II interferon production
GO_0006468Biological processprotein phosphorylation
GO_0048384Biological processretinoic acid receptor signaling pathway
GO_0032720Biological processnegative regulation of tumor necrosis factor production
GO_0071300Biological processcellular response to retinoic acid
GO_0031641Biological processregulation of myelination
GO_0008285Biological processnegative regulation of cell population proliferation
GO_0001657Biological processureteric bud development
GO_0060010Biological processSertoli cell fate commitment
GO_1902894Biological processnegative regulation of miRNA transcription
GO_0002068Biological processglandular epithelial cell development
GO_0007565Biological processfemale pregnancy
GO_0051099Biological processpositive regulation of binding
GO_0043277Biological processapoptotic cell clearance
GO_0032754Biological processpositive regulation of interleukin-5 production
GO_0042981Biological processregulation of apoptotic process
GO_0007281Biological processgerm cell development
GO_0060324Biological processface development
GO_0001843Biological processneural tube closure
GO_0031076Biological processembryonic camera-type eye development
GO_0071222Biological processcellular response to lipopolysaccharide
GO_0032526Biological processresponse to retinoic acid
GO_0045787Biological processpositive regulation of cell cycle
GO_0045630Biological processpositive regulation of T-helper 2 cell differentiation
GO_0032355Biological processresponse to estradiol
GO_0021766Biological processhippocampus development
GO_0032753Biological processpositive regulation of interleukin-4 production
GO_0032736Biological processpositive regulation of interleukin-13 production
GO_0071391Biological processcellular response to estrogen stimulus
GO_0001889Biological processliver development
GO_0045471Biological processresponse to ethanol
GO_0045893Biological processpositive regulation of DNA-templated transcription
GO_0008284Biological processpositive regulation of cell population proliferation
GO_0045892Biological processnegative regulation of DNA-templated transcription
GO_0017148Biological processnegative regulation of translation
GO_0060591Biological processchondroblast differentiation
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0003417Biological processgrowth plate cartilage development
GO_0034097Biological processresponse to cytokine
GO_0060173Biological processlimb development
GO_0033189Biological processresponse to vitamin A
GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_0048167Biological processregulation of synaptic plasticity
GO_0030154Biological processcell differentiation
GO_0030853Biological processnegative regulation of granulocyte differentiation
GO_0009755Biological processhormone-mediated signaling pathway
GO_0045666Biological processpositive regulation of neuron differentiation
GO_0055012Biological processventricular cardiac muscle cell differentiation
GO_0061037Biological processnegative regulation of cartilage development
GO_0005634Cellular componentnucleus
GO_0005730Cellular componentnucleolus
GO_0005654Cellular componentnucleoplasm
GO_0030425Cellular componentdendrite
GO_0015629Cellular componentactin cytoskeleton
GO_0005886Cellular componentplasma membrane
GO_0032991Cellular componentprotein-containing complex
GO_0090575Cellular componentRNA polymerase II transcription regulator complex
GO_0005737Cellular componentcytoplasm
GO_0000785Cellular componentchromatin
GO_0005667Cellular componenttranscription regulator complex
GO_0048471Cellular componentperinuclear region of cytoplasm
GO_0005829Cellular componentcytosol
GO_0001223Molecular functiontranscription coactivator binding
GO_0008270Molecular functionzinc ion binding
GO_0031490Molecular functionchromatin DNA binding
GO_0051018Molecular functionprotein kinase A binding
GO_0000978Molecular functionRNA polymerase II cis-regulatory region sequence-specific DNA binding
GO_1901363Molecular functionheterocyclic compound binding
GO_0003682Molecular functionchromatin binding
GO_0005102Molecular functionsignaling receptor binding
GO_0044323Molecular functionretinoic acid-responsive element binding
GO_0001217Molecular functionDNA-binding transcription repressor activity
GO_0042826Molecular functionhistone deacetylase binding
GO_0019899Molecular functionenzyme binding
GO_0019904Molecular functionprotein domain specific binding
GO_0004879Molecular functionnuclear receptor activity
GO_0051393Molecular functionalpha-actinin binding
GO_0003700Molecular functionDNA-binding transcription factor activity
GO_0001972Molecular functionretinoic acid binding
GO_0005515Molecular functionprotein binding
GO_0000977Molecular functionRNA polymerase II transcription regulatory region sequence-specific DNA binding
GO_0048027Molecular functionmRNA 5'-UTR binding
GO_0000981Molecular functionDNA-binding transcription factor activity, RNA polymerase II-specific
GO_1990837Molecular functionsequence-specific double-stranded DNA binding
GO_0000900Molecular functionmRNA regulatory element binding translation repressor activity
GO_0043422Molecular functionprotein kinase B binding

IV. Literature review

[source]
Gene nameRARA
Protein nameRARA protein
Retinoic acid receptor alpha
Retinoic acid nuclear receptor alpha variant 2 (Retinoic acid receptor, alpha, isoform CRA_b)
Retinoic acid receptor alpha (RAR-alpha) (Nuclear receptor subfamily 1 group B member 1)
Retinoic acid receptor alpha (Retinoic acid receptor, alpha, isoform CRA_e)
RARA protein (Retinoic acid nuclear receptor alpha variant 1) (Retinoic acid receptor, alpha, isoform CRA_c) (cDNA, FLJ92939, Homo sapiens retinoic acid receptor, alpha (RARA), mRNA)
SynonymsNR1B1
hCG_2007196
DescriptionFUNCTION: Receptor for retinoic acid . Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes . The RXR/RAR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5 . In the absence of ligand, the RXR-RAR heterodimers associate with a multiprotein complex containing transcription corepressors that induce histone deacetylation, chromatin condensation and transcriptional suppression . On ligand binding, the corepressors dissociate from the receptors and associate with the coactivators leading to transcriptional activation . Formation of a complex with histone deacetylases might lead to inhibition of RARE DNA element binding and to transcriptional repression . Transcriptional activation and RARE DNA element binding might be supported by the transcription factor KLF2 . RARA plays an essential role in the regulation of retinoic acid-induced germ cell development during spermatogenesis (By similarity). Has a role in the survival of early spermatocytes at the beginning prophase of meiosis (By similarity). In Sertoli cells, may promote the survival and development of early meiotic prophase spermatocytes (By similarity). In concert with RARG, required for skeletal growth, matrix homeostasis and growth plate function (By similarity). Together with RXRA, positively regulates microRNA-10a expression, thereby inhibiting the GATA6/VCAM1 signaling response to pulsatile shear stress in vascular endothelial cells . In association with HDAC3, HDAC5 and HDAC7 corepressors, plays a role in the repression of microRNA-10a and thereby promotes the inflammatory response . .

AccessionsJ3KSJ4
J3QRM2
A8MUP8
ENST00000394089.6 [P10276-1]
Q15997
ENST00000394081.7 [P10276-2]
ENST00000475125.1
ENST00000577646.5
ENST00000254066.10 [P10276-1]
ENST00000425707.7 [P10276-3]
Q6I9R7
F1D8N9
P10276
ENST00000394086.7