I. Expression across cell types
Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| hepatocyte | 4 studies | 25% ± 4% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| hepatocyte | 4 studies | 25% ± 4% |
Insufficient scRNA-seq data for expression of NR1I3 at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| liver | 100% | 5318.84 | 226 / 226 | 91% | 36.56 | 371 / 406 |
| brain | 99% | 71.42 | 2624 / 2642 | 61% | 0.90 | 429 / 705 |
| bladder | 100% | 31.71 | 21 / 21 | 17% | 0.29 | 85 / 504 |
| uterus | 95% | 18.30 | 162 / 170 | 21% | 0.34 | 98 / 459 |
| skin | 90% | 44.96 | 1637 / 1809 | 25% | 0.38 | 119 / 472 |
| esophagus | 95% | 19.73 | 1376 / 1445 | 13% | 0.28 | 24 / 183 |
| kidney | 100% | 189.91 | 89 / 89 | 6% | 0.16 | 54 / 901 |
| intestine | 98% | 28.29 | 951 / 966 | 4% | 0.09 | 20 / 527 |
| breast | 82% | 12.73 | 378 / 459 | 19% | 0.32 | 217 / 1118 |
| lung | 89% | 14.94 | 512 / 578 | 11% | 0.16 | 123 / 1155 |
| muscle | 98% | 36.58 | 789 / 803 | 0% | 0 | 0 / 0 |
| heart | 93% | 29.25 | 800 / 861 | 0% | 0 | 0 / 0 |
| prostate | 90% | 15.51 | 220 / 245 | 1% | 0.02 | 5 / 502 |
| stomach | 79% | 12.26 | 285 / 359 | 9% | 0.14 | 25 / 286 |
| ovary | 83% | 12.69 | 150 / 180 | 3% | 0.04 | 13 / 430 |
| adipose | 86% | 16.39 | 1039 / 1204 | 0% | 0 | 0 / 0 |
| spleen | 85% | 16.71 | 204 / 241 | 0% | 0 | 0 / 0 |
| peripheral blood | 76% | 21.10 | 703 / 929 | 0% | 0 | 0 / 0 |
| blood vessel | 75% | 10.78 | 1004 / 1335 | 0% | 0 | 0 / 0 |
| thymus | 70% | 8.70 | 456 / 653 | 2% | 0.03 | 10 / 605 |
| adrenal gland | 59% | 6.69 | 151 / 258 | 13% | 0.20 | 29 / 230 |
| pancreas | 27% | 2.64 | 89 / 328 | 4% | 0.18 | 7 / 178 |
| tonsil | 0% | 0 | 0 / 0 | 29% | 0.53 | 13 / 45 |
| eye | 0% | 0 | 0 / 0 | 5% | 0.05 | 4 / 80 |
| lymph node | 0% | 0 | 0 / 0 | 3% | 0.04 | 1 / 29 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0001649 | Biological process | osteoblast differentiation |
| GO_0007165 | Biological process | signal transduction |
| GO_0030522 | Biological process | intracellular receptor signaling pathway |
| GO_0000122 | Biological process | negative regulation of transcription by RNA polymerase II |
| GO_0030154 | Biological process | cell differentiation |
| GO_0045944 | Biological process | positive regulation of transcription by RNA polymerase II |
| GO_0005856 | Cellular component | cytoskeleton |
| GO_0005654 | Cellular component | nucleoplasm |
| GO_0005829 | Cellular component | cytosol |
| GO_0005737 | Cellular component | cytoplasm |
| GO_0000785 | Cellular component | chromatin |
| GO_0005634 | Cellular component | nucleus |
| GO_0000978 | Molecular function | RNA polymerase II cis-regulatory region sequence-specific DNA binding |
| GO_0001228 | Molecular function | DNA-binding transcription activator activity, RNA polymerase II-specific |
| GO_0000977 | Molecular function | RNA polymerase II transcription regulatory region sequence-specific DNA binding |
| GO_0000981 | Molecular function | DNA-binding transcription factor activity, RNA polymerase II-specific |
| GO_0004879 | Molecular function | nuclear receptor activity |
| GO_1990837 | Molecular function | sequence-specific double-stranded DNA binding |
| GO_0003700 | Molecular function | DNA-binding transcription factor activity |
| GO_0008270 | Molecular function | zinc ion binding |
| GO_0005515 | Molecular function | protein binding |
| Gene name | NR1I3 |
| Protein name | Nuclear receptor subfamily 1 group I member 3 (Constitutive activator of retinoid response) (Constitutive active response) (Constitutive androstane receptor) (CAR) (Orphan nuclear receptor MB67) Nuclear receptor subfamily 1 group I member 3 (Constitutive androstane receptor) Constitutive androstane receptor SV19 (Constitutive androstane receptor SV20) (Nuclear receptor subfamily 1 group I member 3) Nuclear receptor subfamily 1 group I member 3 Constitutive androstane receptor SV17 (Constitutive androstane receptor SV18) (Nuclear receptor subfamily 1 group I member 3) Constitutive androstane receptor SV2 Constitutive androstane receptor SV21 (Nuclear receptor subfamily 1 group I member 3) Constitutive androstane receptor SV16 Constitutive androstane receptor SV10 (Constitutive androstane receptor SV4) (Constitutive androstane receptor SV9) (Nuclear receptor subfamily 1 group I member 3) |
| Synonyms | hCG_1766510 CAR |
| Description | FUNCTION: Binds and transactivates the retinoic acid response elements that control expression of the retinoic acid receptor beta 2 and alcohol dehydrogenase 3 genes. Transactivates both the phenobarbital responsive element module of the human CYP2B6 gene and the CYP3A4 xenobiotic response element. FUNCTION: Binds and transactivates the retinoic acid response elements that control expression of the retinoic acid receptor beta 2 and alcohol dehydrogenase 3 genes. Transactivates both the phenobarbital responsive element module of the human CYP2B6 gene and the CYP3A4 xenobiotic response element. . FUNCTION: Binds and transactivates the retinoic acid response elements that control expression of the retinoic acid receptor beta 2 and alcohol dehydrogenase 3 genes. Transactivates both the phenobarbital responsive element module of the human CYP2B6 gene and the CYP3A4 xenobiotic response element. . FUNCTION: Binds and transactivates the retinoic acid response elements that control expression of the retinoic acid receptor beta 2 and alcohol dehydrogenase 3 genes. Transactivates both the phenobarbital responsive element module of the human CYP2B6 gene and the CYP3A4 xenobiotic response element. . FUNCTION: Binds and transactivates the retinoic acid response elements that control expression of the retinoic acid receptor beta 2 and alcohol dehydrogenase 3 genes. Transactivates both the phenobarbital responsive element module of the human CYP2B6 gene and the CYP3A4 xenobiotic response element. . FUNCTION: Binds and transactivates the retinoic acid response elements that control expression of the retinoic acid receptor beta 2 and alcohol dehydrogenase 3 genes. Transactivates both the phenobarbital responsive element module of the human CYP2B6 gene and the CYP3A4 xenobiotic response element. . FUNCTION: Binds and transactivates the retinoic acid response elements that control expression of the retinoic acid receptor beta 2 and alcohol dehydrogenase 3 genes. Transactivates both the phenobarbital responsive element module of the human CYP2B6 gene and the CYP3A4 xenobiotic response element. . |
| Accessions | Q14994 ENST00000511676.5 [Q14994-5] ENST00000367984.8 [Q14994-7] ENST00000412844.6 [Q14994-11] D6REZ7 C0H5Y2 ENST00000506018.5 ENST00000506209.5 ENST00000367979.6 [Q14994-8] ENST00000628566.2 ENST00000512340.5 ENST00000437437.6 [Q14994-9] ENST00000512372.5 [Q14994-16] Q6GZ72 ENST00000367980.6 [Q14994-8] ENST00000508740.5 [Q14994-10] ENST00000442691.6 [Q14994-12] ENST00000428574.6 [Q14994-13] Q6GZ74 Q6GZ88 ENST00000367982.8 [Q14994-1] ENST00000504010.5 [Q14994-4] ENST00000510951.5 ENST00000367983.9 [Q14994-2] ENST00000511944.5 ENST00000515621.5 ENST00000508387.5 ENST00000505005.5 [Q14994-15] Q6GZ69 ENST00000515452.1 ENST00000511748.5 ENST00000367985.7 [Q14994-3] Q6GZ81 F1DAL4 B7Z8R7 ENST00000507215.5 ENST00000502848.5 ENST00000367981.7 [Q14994-6] Q6GZ75 ENST00000502985.5 E9PCF2 B6ZGT2 Q6GZ70 |
