RARB report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0031641Biological processregulation of myelination
GO_0001657Biological processureteric bud development
GO_0003417Biological processgrowth plate cartilage development
GO_0007165Biological processsignal transduction
GO_0048566Biological processembryonic digestive tract development
GO_0035264Biological processmulticellular organism growth
GO_0061351Biological processneural precursor cell proliferation
GO_0072089Biological processstem cell proliferation
GO_0021756Biological processstriatum development
GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_0002068Biological processglandular epithelial cell development
GO_0035116Biological processembryonic hindlimb morphogenesis
GO_0032331Biological processnegative regulation of chondrocyte differentiation
GO_2000647Biological processnegative regulation of stem cell proliferation
GO_0022008Biological processneurogenesis
GO_0030154Biological processcell differentiation
GO_0009755Biological processhormone-mediated signaling pathway
GO_0006915Biological processapoptotic process
GO_0048384Biological processretinoic acid receptor signaling pathway
GO_0048048Biological processembryonic eye morphogenesis
GO_0043065Biological processpositive regulation of apoptotic process
GO_0055012Biological processventricular cardiac muscle cell differentiation
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0005654Cellular componentnucleoplasm
GO_0005737Cellular componentcytoplasm
GO_0000785Cellular componentchromatin
GO_0005634Cellular componentnucleus
GO_0003677Molecular functionDNA binding
GO_0000978Molecular functionRNA polymerase II cis-regulatory region sequence-specific DNA binding
GO_1901363Molecular functionheterocyclic compound binding
GO_0000981Molecular functionDNA-binding transcription factor activity, RNA polymerase II-specific
GO_0044877Molecular functionprotein-containing complex binding
GO_0004879Molecular functionnuclear receptor activity
GO_1990837Molecular functionsequence-specific double-stranded DNA binding
GO_0046965Molecular functionnuclear retinoid X receptor binding
GO_0008270Molecular functionzinc ion binding

IV. Literature review

[source]
Gene nameRARB
Protein nameRARB protein
Retinoic acid receptor beta (Nuclear receptor subfamily 1 group B member 2)
Retinoic acid receptor beta
Retinoic acid receptor beta (RAR-beta) (HBV-activated protein) (Nuclear receptor subfamily 1 group B member 2) (RAR-epsilon)
SynonymsHAP
NR1B2
hCG_26863
DescriptionFUNCTION: Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RXR/RAR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. In the absence or presence of hormone ligand, acts mainly as an activator of gene expression due to weak binding to corepressors . The RXRA/RARB heterodimer can act as a repressor on the DR1 element and as an activator on the DR5 element . In concert with RARG, required for skeletal growth, matrix homeostasis and growth plate function (By similarity). .

AccessionsENST00000687676.1 [P10826-1]
F1D8S6
ENST00000689700.1
Q6FHY0
ENST00000383772.9 [P10826-1]
ENST00000330688.9 [P10826-2]
A0A8I5KVN9
ENST00000690398.1
ENST00000692640.1
A0A8I5KXD0
A0A8I5KQX3
ENST00000455576.2
ENST00000691580.1
Q15299
ENST00000688892.1 [P10826-1]
ENST00000479097.6
A0A8I5KWP3
Q86UC5
ENST00000693580.1
ENST00000685523.1
ENST00000693261.1 [P10826-3]
A0A8I5KXT3
D6RBI3
A0A8I5KNZ0
A0A8I5KVP8
ENST00000687353.1 [P10826-1]
ENST00000458646.2 [P10826-3]
ENST00000686715.1 [P10826-1]
Q5QHG3
ENST00000687083.1
A0A8I5KUH8
A0A8I5KVJ9
ENST00000383772
ENST00000437042.7 [P10826-3]
A0A8I5KSR9
P10826
ENST00000691912.1
ENST00000480001.6