AHR report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0010468Biological processregulation of gene expression
GO_0002841Biological processnegative regulation of T cell mediated immune response to tumor cell
GO_0006805Biological processxenobiotic metabolic process
GO_1904613Biological processcellular response to 2,3,7,8-tetrachlorodibenzodioxine
GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_0071219Biological processcellular response to molecule of bacterial origin
GO_0030522Biological processintracellular receptor signaling pathway
GO_0019933Biological processcAMP-mediated signaling
GO_0032922Biological processcircadian regulation of gene expression
GO_0002819Biological processregulation of adaptive immune response
GO_0030888Biological processregulation of B cell proliferation
GO_0071320Biological processcellular response to cAMP
GO_0050728Biological processnegative regulation of inflammatory response
GO_0045893Biological processpositive regulation of DNA-templated transcription
GO_1904322Biological processcellular response to forskolin
GO_0006355Biological processregulation of DNA-templated transcription
GO_0001568Biological processblood vessel development
GO_0006915Biological processapoptotic process
GO_0009410Biological processresponse to xenobiotic stimulus
GO_0009636Biological processresponse to toxic substance
GO_0045892Biological processnegative regulation of DNA-templated transcription
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0032991Cellular componentprotein-containing complex
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0034752Cellular componentcytosolic aryl hydrocarbon receptor complex
GO_0034753Cellular componentnuclear aryl hydrocarbon receptor complex
GO_0005737Cellular componentcytoplasm
GO_0034751Cellular componentaryl hydrocarbon receptor complex
GO_0000785Cellular componentchromatin
GO_0005667Cellular componenttranscription regulator complex
GO_0005634Cellular componentnucleus
GO_0003677Molecular functionDNA binding
GO_0042803Molecular functionprotein homodimerization activity
GO_0017025Molecular functionTBP-class protein binding
GO_0000981Molecular functionDNA-binding transcription factor activity, RNA polymerase II-specific
GO_0000987Molecular functioncis-regulatory region sequence-specific DNA binding
GO_0051879Molecular functionHsp90 protein binding
GO_0000976Molecular functiontranscription cis-regulatory region binding
GO_0004879Molecular functionnuclear receptor activity
GO_0001094Molecular functionTFIID-class transcription factor complex binding
GO_1990837Molecular functionsequence-specific double-stranded DNA binding
GO_0061629Molecular functionRNA polymerase II-specific DNA-binding transcription factor binding
GO_0001223Molecular functiontranscription coactivator binding
GO_0003700Molecular functionDNA-binding transcription factor activity
GO_0046982Molecular functionprotein heterodimerization activity
GO_0070888Molecular functionE-box binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameAHR
Protein nameAlternative protein AHR
Aryl hydrocarbon receptor (Ah receptor) (AhR) (Class E basic helix-loop-helix protein 76) (bHLHe76)
Aryl hydrocarbon receptor
SynonymsBHLHE76
DescriptionFUNCTION: Ligand-activated transcription factor that enables cells to adapt to changing conditions by sensing compounds from the environment, diet, microbiome and cellular metabolism, and which plays important roles in development, immunity and cancer . Upon ligand binding, translocates into the nucleus, where it heterodimerizes with ARNT and induces transcription by binding to xenobiotic response elements (XRE) . Regulates a variety of biological processes, including angiogenesis, hematopoiesis, drug and lipid metabolism, cell motility and immune modulation . Xenobiotics can act as ligands: upon xenobiotic-binding, activates the expression of multiple phase I and II xenobiotic chemical metabolizing enzyme genes (such as the CYP1A1 gene) . Mediates biochemical and toxic effects of halogenated aromatic hydrocarbons . Next to xenobiotics, natural ligands derived from plants, microbiota, and endogenous metabolism are potent AHR agonists . Tryptophan (Trp) derivatives constitute an important class of endogenous AHR ligands . Acts as a negative regulator of anti-tumor immunity: indoles and kynurenic acid generated by Trp catabolism act as ligand and activate AHR, thereby promoting AHR-driven cancer cell motility and suppressing adaptive immunity . Regulates the circadian clock by inhibiting the basal and circadian expression of the core circadian component PER1 . Inhibits PER1 by repressing the CLOCK-BMAL1 heterodimer mediated transcriptional activation of PER1 . The heterodimer ARNT:AHR binds to core DNA sequence 5'-TGCGTG-3' within the dioxin response element (DRE) of target gene promoters and activates their transcription . .

AccessionsENST00000242057.9
P35869
L0R578
ENST00000642825.1
A0A2R8Y7G1
ENST00000463496.1