NR4A2 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
natural killer cell	32 studies	39% ± 18%	Explore
CD8-positive, alpha-beta T cell	30 studies	33% ± 12%	Explore
macrophage	28 studies	41% ± 17%	Explore
B cell	26 studies	39% ± 14%	Explore
conventional dendritic cell	26 studies	42% ± 15%	Explore
CD4-positive, alpha-beta T cell	23 studies	30% ± 13%	Explore
classical monocyte	21 studies	35% ± 15%	Explore
T cell	19 studies	41% ± 19%	Explore
mast cell	18 studies	45% ± 15%	Explore
regulatory T cell	18 studies	34% ± 15%	Explore
dendritic cell	17 studies	37% ± 12%	Explore
non-classical monocyte	16 studies	35% ± 12%	Explore
monocyte	15 studies	40% ± 20%	Explore
CD16-negative, CD56-bright natural killer cell, human	15 studies	37% ± 21%	Explore
mature NK T cell	15 studies	36% ± 11%	Explore
pericyte	15 studies	32% ± 17%	Explore
fibroblast	15 studies	29% ± 9%	Explore
gamma-delta T cell	14 studies	40% ± 19%	Explore
memory B cell	14 studies	45% ± 19%	Explore
naive B cell	13 studies	35% ± 13%	Explore
CD16-positive, CD56-dim natural killer cell, human	12 studies	40% ± 15%	Explore
mucosal invariant T cell	12 studies	36% ± 20%	Explore
smooth muscle cell	11 studies	31% ± 10%	Explore
myeloid cell	10 studies	45% ± 17%	Explore
endothelial cell	9 studies	27% ± 8%	Explore
CD8-positive, alpha-beta memory T cell	9 studies	46% ± 19%	Explore
effector memory CD8-positive, alpha-beta T cell	8 studies	36% ± 18%	Explore
CD4-positive, alpha-beta memory T cell	8 studies	40% ± 22%	Explore
leukocyte	8 studies	34% ± 16%	Explore
ciliated cell	8 studies	31% ± 18%	Explore
plasmacytoid dendritic cell	8 studies	37% ± 18%	Explore
T follicular helper cell	7 studies	36% ± 14%	Explore
innate lymphoid cell	7 studies	36% ± 9%	Explore
effector CD8-positive, alpha-beta T cell	5 studies	30% ± 7%	Explore
mononuclear phagocyte	5 studies	48% ± 15%	Explore
endothelial cell of vascular tree	5 studies	32% ± 19%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	5 studies	33% ± 15%	Explore
connective tissue cell	5 studies	40% ± 8%	Explore
plasma cell	4 studies	20% ± 1%	Explore
epithelial cell	4 studies	36% ± 23%	Explore
immature B cell	4 studies	28% ± 7%	Explore
myofibroblast cell	4 studies	25% ± 8%	Explore
CD4-positive helper T cell	4 studies	33% ± 11%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	4 studies	32% ± 14%	Explore
granulocyte	4 studies	33% ± 6%	Explore
group 3 innate lymphoid cell	4 studies	44% ± 17%	Explore
melanocyte	4 studies	24% ± 8%	Explore
monocyte-derived dendritic cell	3 studies	48% ± 22%	Explore
hematopoietic stem cell	3 studies	32% ± 7%	Explore
abnormal cell	3 studies	26% ± 10%	Explore
intermediate monocyte	3 studies	47% ± 11%	Explore
effector memory CD4-positive, alpha-beta T cell	3 studies	42% ± 2%	Explore
neutrophil	3 studies	40% ± 17%	Explore
goblet cell	3 studies	23% ± 8%	Explore
glial cell	3 studies	18% ± 1%	Explore
basal cell	3 studies	23% ± 5%	Explore
T-helper 17 cell	3 studies	30% ± 11%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	3 studies	20% ± 4%	Explore
endothelial cell of lymphatic vessel	3 studies	30% ± 8%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
peripheral blood	10 studies	26% ± 12%	Explore
lung	8 studies	29% ± 10%	Explore
intestine	5 studies	22% ± 5%	Explore
uterus	5 studies	33% ± 11%	Explore
lymph node	4 studies	38% ± 9%	Explore
kidney	3 studies	31% ± 8%	Explore
bone marrow	3 studies	26% ± 8%	Explore
breast	3 studies	30% ± 10%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
ovary	97%	21137.47	175 / 180	88%	18.32	379 / 430
breast	86%	2761.56	394 / 459	85%	27.01	952 / 1118
prostate	82%	3587.32	201 / 245	89%	31.51	445 / 502
lung	85%	2908.95	493 / 578	84%	22.52	974 / 1155
stomach	78%	2480.55	279 / 359	85%	18.15	243 / 286
thymus	78%	2589.91	510 / 653	74%	18.23	450 / 605
skin	56%	1314.70	1007 / 1809	85%	23.28	403 / 472
esophagus	51%	1722.64	730 / 1445	89%	25.27	163 / 183
adrenal gland	69%	7277.16	178 / 258	70%	50.03	160 / 230
intestine	52%	1253.76	500 / 966	85%	17.41	447 / 527
bladder	62%	1582.57	13 / 21	73%	13.94	368 / 504
uterus	54%	1353.95	91 / 170	79%	17.85	362 / 459
kidney	52%	2434.26	46 / 89	62%	13.15	556 / 901
pancreas	33%	598.90	107 / 328	78%	14.34	139 / 178
blood vessel	91%	6128.83	1216 / 1335	0%	0	0 / 0
brain	46%	1273.20	1210 / 2642	45%	5.47	318 / 705
adipose	87%	4313.23	1043 / 1204	0%	0	0 / 0
liver	46%	1650.49	105 / 226	34%	5.02	140 / 406
tonsil	0%	0	0 / 0	80%	51.14	36 / 45
heart	53%	2616.65	456 / 861	0%	0	0 / 0
muscle	38%	823.72	309 / 803	0%	0	0 / 0
lymph node	0%	0	0 / 0	34%	2.98	10 / 29
peripheral blood	33%	1078.16	303 / 929	0%	0	0 / 0
eye	0%	0	0 / 0	25%	2.80	20 / 80
spleen	24%	584.75	58 / 241	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

III. Associated gene sets

GO_0071376	Biological process	cellular response to corticotropin-releasing hormone stimulus
GO_0006366	Biological process	transcription by RNA polymerase II
GO_0009791	Biological process	post-embryonic development
GO_1904948	Biological process	midbrain dopaminergic neuron differentiation
GO_0006357	Biological process	regulation of transcription by RNA polymerase II
GO_0051866	Biological process	general adaptation syndrome
GO_0042053	Biological process	regulation of dopamine metabolic process
GO_0008344	Biological process	adult locomotory behavior
GO_0021953	Biological process	central nervous system neuron differentiation
GO_0030522	Biological process	intracellular receptor signaling pathway
GO_0001764	Biological process	neuron migration
GO_0043576	Biological process	regulation of respiratory gaseous exchange
GO_0000122	Biological process	negative regulation of transcription by RNA polymerase II
GO_0071542	Biological process	dopaminergic neuron differentiation
GO_0060070	Biological process	canonical Wnt signaling pathway
GO_0042416	Biological process	dopamine biosynthetic process
GO_0051402	Biological process	neuron apoptotic process
GO_0006351	Biological process	DNA-templated transcription
GO_0021952	Biological process	central nervous system projection neuron axonogenesis
GO_0042551	Biological process	neuron maturation
GO_0034599	Biological process	cellular response to oxidative stress
GO_0001666	Biological process	response to hypoxia
GO_2001234	Biological process	negative regulation of apoptotic signaling pathway
GO_0021986	Biological process	habenula development
GO_0001975	Biological process	response to amphetamine
GO_0043524	Biological process	negative regulation of neuron apoptotic process
GO_0045444	Biological process	fat cell differentiation
GO_0045944	Biological process	positive regulation of transcription by RNA polymerase II
GO_0016607	Cellular component	nuclear speck
GO_0032991	Cellular component	protein-containing complex
GO_0005654	Cellular component	nucleoplasm
GO_0005737	Cellular component	cytoplasm
GO_0000785	Cellular component	chromatin
GO_0005667	Cellular component	transcription regulator complex
GO_0005634	Cellular component	nucleus
GO_0003677	Molecular function	DNA binding
GO_0000978	Molecular function	RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO_0035259	Molecular function	nuclear glucocorticoid receptor binding
GO_0001228	Molecular function	DNA-binding transcription activator activity, RNA polymerase II-specific
GO_0000981	Molecular function	DNA-binding transcription factor activity, RNA polymerase II-specific
GO_0004879	Molecular function	nuclear receptor activity
GO_1990837	Molecular function	sequence-specific double-stranded DNA binding
GO_0008013	Molecular function	beta-catenin binding
GO_0046965	Molecular function	nuclear retinoid X receptor binding
GO_0008270	Molecular function	zinc ion binding
GO_0046982	Molecular function	protein heterodimerization activity
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	NR4A2
Protein name	Nuclear receptor subfamily 4 group A member 2 Orphan nuclear receptor NR4A2 isoform 2 Nuclear receptor subfamily 4 group A member 2 (Immediate-early response protein NOT) (Orphan nuclear receptor NURR1) (Transcriptionally-inducible nuclear receptor) Orphan nuclear receptor NR4A2 isoform 1
Synonyms	NOT TINUR NURR1
Description	FUNCTION: Transcriptional regulator which is important for the differentiation and maintenance of meso-diencephalic dopaminergic (mdDA) neurons during development . It is crucial for expression of a set of genes such as SLC6A3, SLC18A2, TH and DRD2 which are essential for development of mdDA neurons (By similarity). .
Accessions	E9PBQ4 ENST00000426264.5 [P43354-2] ENST00000700230.1 ENST00000424077.1 C0KWD1 C9IYM5 F1D8N6 C0KWD2 C9JWQ1 ENST00000417972.5 ENST00000339562.9 [P43354-1] A0A0S2Z418 F1DAL2 ENST00000421709.2 ENST00000429376.5 P43354 ENST00000409572.5 [P43354-1] F8W6I3 ENST00000675870.1 A0A8V8TPV9 A0A8V8TR19 ENST00000700231.1 ENST00000700229.1 ENST00000409108.6 A0A8V8TPF8 C9J8W4 ENST00000417764.5 ENST00000700228.1

NR4A2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review