NR4A3 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0071376Biological processcellular response to corticotropin-releasing hormone stimulus
GO_0097009Biological processenergy homeostasis
GO_0061469Biological processregulation of type B pancreatic cell proliferation
GO_0010828Biological processpositive regulation of glucose transmembrane transport
GO_2000253Biological processpositive regulation of feeding behavior
GO_0010613Biological processpositive regulation of cardiac muscle hypertrophy
GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_1904754Biological processpositive regulation of vascular associated smooth muscle cell migration
GO_0048661Biological processpositive regulation of smooth muscle cell proliferation
GO_0030522Biological processintracellular receptor signaling pathway
GO_0031100Biological processanimal organ regeneration
GO_0045333Biological processcellular respiration
GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_0007369Biological processgastrulation
GO_0048660Biological processregulation of smooth muscle cell proliferation
GO_0048008Biological processplatelet-derived growth factor receptor signaling pathway
GO_0043303Biological processmast cell degranulation
GO_0050679Biological processpositive regulation of epithelial cell proliferation
GO_0071870Biological processcellular response to catecholamine stimulus
GO_0035556Biological processintracellular signal transduction
GO_0044320Biological processcellular response to leptin stimulus
GO_0032765Biological processpositive regulation of mast cell cytokine production
GO_0038097Biological processpositive regulation of mast cell activation by Fc-epsilon receptor signaling pathway
GO_0035726Biological processcommon myeloid progenitor cell proliferation
GO_0043401Biological processsteroid hormone receptor signaling pathway
GO_1900625Biological processpositive regulation of monocyte aggregation
GO_1904707Biological processpositive regulation of vascular associated smooth muscle cell proliferation
GO_0045444Biological processfat cell differentiation
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0005654Cellular componentnucleoplasm
GO_0000785Cellular componentchromatin
GO_0005667Cellular componenttranscription regulator complex
GO_0005634Cellular componentnucleus
GO_0003677Molecular functionDNA binding
GO_0042803Molecular functionprotein homodimerization activity
GO_0000978Molecular functionRNA polymerase II cis-regulatory region sequence-specific DNA binding
GO_0035259Molecular functionnuclear glucocorticoid receptor binding
GO_0001228Molecular functionDNA-binding transcription activator activity, RNA polymerase II-specific
GO_0000981Molecular functionDNA-binding transcription factor activity, RNA polymerase II-specific
GO_0003707Molecular functionnuclear steroid receptor activity
GO_0004879Molecular functionnuclear receptor activity
GO_0019901Molecular functionprotein kinase binding
GO_0008270Molecular functionzinc ion binding
GO_0035497Molecular functioncAMP response element binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameNR4A3
Protein nameNR4A3/PIK3R1 fusion protein
Nuclear receptor subfamily 4 group A member 3 (Mitogen-induced nuclear orphan receptor) (Neuron-derived orphan receptor 1) (Nuclear hormone receptor NOR-1)
SynonymsCSMF
CHN
fusion
MINOR
PIK3R1
TEC
NOR1
DescriptionFUNCTION: Transcriptional activator that binds to regulatory elements in promoter regions in a cell- and response element (target)-specific manner. Induces gene expression by binding as monomers to the NR4A1 response element (NBRE) 5'-AAAAGGTCA-3' site and as homodimers to the Nur response element (NurRE) site in the promoter of their regulated target genes (By similarity). Plays a role in the regulation of proliferation, survival and differentiation of many different cell types and also in metabolism and inflammation. Mediates proliferation of vascular smooth muscle, myeloid progenitor cell and type B pancreatic cells; promotes mitogen-induced vascular smooth muscle cell proliferation through transactivation of SKP2 promoter by binding a NBRE site (By similarity). Upon PDGF stimulation, stimulates vascular smooth muscle cell proliferation by regulating CCND1 and CCND2 expression. In islets, induces type B pancreatic cell proliferation through up-regulation of genes that activate cell cycle, as well as genes that cause degradation of the CDKN1A (By similarity). Negatively regulates myeloid progenitor cell proliferation by repressing RUNX1 in a NBRE site-independent manner. During inner ear, plays a role as a key mediator of the proliferative growth phase of semicircular canal development (By similarity). Mediates also survival of neuron and smooth muscle cells; mediates CREB-induced neuronal survival, and during hippocampus development, plays a critical role in pyramidal cell survival and axonal guidance. Is required for S phase entry of the cell cycle and survival of smooth muscle cells by inducing CCND1, resulting in RB1 phosphorylation. Binds to NBRE motif in CCND1 promoter, resulting in the activation of the promoter and CCND1 transcription (By similarity). Also plays a role in inflammation; upon TNF stimulation, mediates monocyte adhesion by inducing the expression of VCAM1 and ICAM1 by binding to the NBRE consensus site (By similarity) . In mast cells activated by Fc-epsilon receptor cross-linking, promotes the synthesis and release of cytokines but impairs events leading to degranulation (By similarity). Also plays a role in metabolism; by modulating feeding behavior; and by playing a role in energy balance by inhibiting the glucocorticoid-induced orexigenic neuropeptides AGRP expression, at least in part by forming a complex with activated NR3C1 on the AGRP- glucocorticoid response element (GRE), and thus weakening the DNA binding activity of NR3C1. Upon catecholamines stimulation, regulates gene expression that controls oxidative metabolism in skeletal muscle (By similarity). Plays a role in glucose transport by regulating translocation of the SLC2A4 glucose transporter to the cell surface . Finally, during gastrulation plays a crucial role in the formation of anterior mesoderm by controlling cell migration. Inhibits adipogenesis (By similarity). Also participates in cardiac hypertrophy by activating PARP1 (By similarity). .

AccessionsENST00000618101.4 [Q92570-3]
A0A1D8GZE0
ENST00000395097.7 [Q92570-1]
ENST00000338488.8 [Q92570-2]
Q92570
ENST00000330847.1 [Q92570-3]