NR5A1 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of NR5A1 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of NR5A1 at tissue level.

III. Associated gene sets

GO_0030238Biological processmale sex determination
GO_0009888Biological processtissue development
GO_0001553Biological processluteinization
GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_0010628Biological processpositive regulation of gene expression
GO_0030522Biological processintracellular receptor signaling pathway
GO_0050810Biological processregulation of steroid biosynthetic process
GO_0060008Biological processSertoli cell differentiation
GO_0051457Biological processmaintenance of protein location in nucleus
GO_0007538Biological processprimary sex determination
GO_0030325Biological processadrenal gland development
GO_2000020Biological processpositive regulation of male gonad development
GO_0009755Biological processhormone-mediated signaling pathway
GO_0008584Biological processmale gonad development
GO_0033327Biological processLeydig cell differentiation
GO_0008585Biological processfemale gonad development
GO_0042445Biological processhormone metabolic process
GO_0007530Biological processsex determination
GO_2000195Biological processnegative regulation of female gonad development
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0005654Cellular componentnucleoplasm
GO_0090575Cellular componentRNA polymerase II transcription regulator complex
GO_0005829Cellular componentcytosol
GO_0000785Cellular componentchromatin
GO_0005634Cellular componentnucleus
GO_0003677Molecular functionDNA binding
GO_0019899Molecular functionenzyme binding
GO_0000978Molecular functionRNA polymerase II cis-regulatory region sequence-specific DNA binding
GO_0000977Molecular functionRNA polymerase II transcription regulatory region sequence-specific DNA binding
GO_0000981Molecular functionDNA-binding transcription factor activity, RNA polymerase II-specific
GO_0043565Molecular functionsequence-specific DNA binding
GO_0003682Molecular functionchromatin binding
GO_0005543Molecular functionphospholipid binding
GO_0004879Molecular functionnuclear receptor activity
GO_0001221Molecular functiontranscription coregulator binding
GO_1990837Molecular functionsequence-specific double-stranded DNA binding
GO_0008270Molecular functionzinc ion binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameNR5A1
Protein nameNuclear receptor subfamily 5 group A member 1
Steroidogenic factor 1 (SF-1) (STF-1) (hSF-1) (Adrenal 4-binding protein) (Fushi tarazu factor homolog 1) (Nuclear receptor subfamily 5 group A member 1) (Steroid hormone receptor Ad4BP)
Alternative protein NR5A1
Steroidogenic factor 1 (Nuclear receptor subfamily 5 group A member 1)
SynonymsAD4BP
SF1
FTZF1
DescriptionFUNCTION: Transcriptional activator. Essential for sexual differentiation and formation of the primary steroidogenic tissues . Binds to the Ad4 site found in the promoter region of steroidogenic P450 genes such as CYP11A, CYP11B and CYP21B. Also regulates the AMH/Muellerian inhibiting substance gene as well as the AHCH and STAR genes. 5'-YCAAGGYC-3' and 5'-RRAGGTCA-3' are the consensus sequences for the recognition by NR5A1 . The SFPQ-NONO-NR5A1 complex binds to the CYP17 promoter and regulates basal and cAMP-dependent transcriptional activity. Binds phosphatidylcholine (By similarity). Binds phospholipids with a phosphatidylinositol (PI) headgroup, in particular PI(3,4)P2 and PI(3,4,5)P3. Activated by the phosphorylation of NR5A1 by HIPK3 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation. .

AccessionsL8ECB8
ENST00000373588.9
A0A1E1GJF0
F1DAM0
B6ZGU8
Q13285
Q5T6F7
Q5T6F6
ENST00000455734.1
ENST00000373587.3
ENST00000620110.4
F1D8R8