NKX3-1 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of NKX3-1 at tissue level.

III. Associated gene sets

GO_0060037Biological processpharyngeal system development
GO_0033574Biological processresponse to testosterone
GO_0060442Biological processbranching involved in prostate gland morphogenesis
GO_0006919Biological processactivation of cysteine-type endopeptidase activity involved in apoptotic process
GO_0008285Biological processnegative regulation of cell population proliferation
GO_0051781Biological processpositive regulation of cell division
GO_0071466Biological processcellular response to xenobiotic stimulus
GO_0007431Biological processsalivary gland development
GO_0060664Biological processepithelial cell proliferation involved in salivary gland morphogenesis
GO_0048754Biological processbranching morphogenesis of an epithelial tube
GO_0010629Biological processnegative regulation of gene expression
GO_0007507Biological processheart development
GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_0001656Biological processmetanephros development
GO_0010628Biological processpositive regulation of gene expression
GO_0006974Biological processDNA damage response
GO_0032880Biological processregulation of protein localization
GO_0071383Biological processcellular response to steroid hormone stimulus
GO_2001244Biological processpositive regulation of intrinsic apoptotic signaling pathway
GO_2000836Biological processpositive regulation of androgen secretion
GO_0035907Biological processdorsal aorta development
GO_0071347Biological processcellular response to interleukin-1
GO_0001934Biological processpositive regulation of protein phosphorylation
GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_0050680Biological processnegative regulation of epithelial cell proliferation
GO_0043280Biological processpositive regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO_0060770Biological processnegative regulation of epithelial cell proliferation involved in prostate gland development
GO_0045931Biological processpositive regulation of mitotic cell cycle
GO_0071356Biological processcellular response to tumor necrosis factor
GO_0045893Biological processpositive regulation of DNA-templated transcription
GO_0030154Biological processcell differentiation
GO_0006355Biological processregulation of DNA-templated transcription
GO_0001756Biological processsomitogenesis
GO_0060767Biological processepithelial cell proliferation involved in prostate gland development
GO_0043491Biological processphosphatidylinositol 3-kinase/protein kinase B signal transduction
GO_0043569Biological processnegative regulation of insulin-like growth factor receptor signaling pathway
GO_0008584Biological processmale gonad development
GO_0006915Biological processapoptotic process
GO_0051897Biological processpositive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
GO_0008284Biological processpositive regulation of cell population proliferation
GO_2001235Biological processpositive regulation of apoptotic signaling pathway
GO_0030521Biological processandrogen receptor signaling pathway
GO_0045892Biological processnegative regulation of DNA-templated transcription
GO_0071456Biological processcellular response to hypoxia
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0005654Cellular componentnucleoplasm
GO_0090734Cellular componentsite of DNA damage
GO_0005829Cellular componentcytosol
GO_0000785Cellular componentchromatin
GO_0005634Cellular componentnucleus
GO_0000978Molecular functionRNA polymerase II cis-regulatory region sequence-specific DNA binding
GO_0140297Molecular functionDNA-binding transcription factor binding
GO_0000981Molecular functionDNA-binding transcription factor activity, RNA polymerase II-specific
GO_0043565Molecular functionsequence-specific DNA binding
GO_0000976Molecular functiontranscription cis-regulatory region binding
GO_0004879Molecular functionnuclear receptor activity
GO_0008656Molecular functioncysteine-type endopeptidase activator activity involved in apoptotic process
GO_1990837Molecular functionsequence-specific double-stranded DNA binding
GO_0140416Molecular functiontranscription regulator inhibitor activity
GO_0030331Molecular functionnuclear estrogen receptor binding
GO_0003700Molecular functionDNA-binding transcription factor activity
GO_0097162Molecular functionMADS box domain binding
GO_0005515Molecular functionprotein binding
GO_0042826Molecular functionhistone deacetylase binding

IV. Literature review

[source]
Gene nameNKX3-1
Protein nameHomeobox protein Nkx-3.1 (Homeobox protein NK-3 homolog A)
SynonymsNKX3A
NKX3.1
DescriptionFUNCTION: Transcription factor, which binds preferentially the consensus sequence 5'-TAAGT[AG]-3' and can behave as a transcriptional repressor. Plays an important role in normal prostate development, regulating proliferation of glandular epithelium and in the formation of ducts in prostate. Acts as a tumor suppressor controlling prostate carcinogenesis, as shown by the ability to inhibit proliferation and invasion activities of PC-3 prostate cancer cells. .

AccessionsQ99801
ENST00000380871.5 [Q99801-1]
ENST00000523261.1 [Q99801-3]