RORC report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of RORC at tissue level.

III. Associated gene sets

GO_0006805Biological processxenobiotic metabolic process
GO_0019218Biological processregulation of steroid metabolic process
GO_0072539Biological processT-helper 17 cell differentiation
GO_0036315Biological processcellular response to sterol
GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_0030522Biological processintracellular receptor signaling pathway
GO_0010906Biological processregulation of glucose metabolic process
GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_0032922Biological processcircadian regulation of gene expression
GO_0045893Biological processpositive regulation of DNA-templated transcription
GO_0042753Biological processpositive regulation of circadian rhythm
GO_0045598Biological processregulation of fat cell differentiation
GO_0060612Biological processadipose tissue development
GO_0005654Cellular componentnucleoplasm
GO_0016604Cellular componentnuclear body
GO_0000785Cellular componentchromatin
GO_0005634Cellular componentnucleus
GO_0000978Molecular functionRNA polymerase II cis-regulatory region sequence-specific DNA binding
GO_0001227Molecular functionDNA-binding transcription repressor activity, RNA polymerase II-specific
GO_0000981Molecular functionDNA-binding transcription factor activity, RNA polymerase II-specific
GO_0004879Molecular functionnuclear receptor activity
GO_1990837Molecular functionsequence-specific double-stranded DNA binding
GO_0003700Molecular functionDNA-binding transcription factor activity
GO_0008270Molecular functionzinc ion binding
GO_0008142Molecular functionoxysterol binding
GO_0005515Molecular functionprotein binding
GO_0098531Molecular functionligand-activated transcription factor activity

IV. Literature review

[source]
Gene nameRORC
Protein nameRAR-related orphan receptor C (RORC protein)
Nuclear receptor ROR-gamma (Nuclear receptor RZR-gamma) (Nuclear receptor subfamily 1 group F member 3) (RAR-related orphan receptor C) (Retinoid-related orphan receptor-gamma)
RORC
RAR related orphan receptor C
SynonymsNR1F3
RZRG
RORG
DescriptionFUNCTION: Nuclear receptor that binds DNA as a monomer to ROR response elements (RORE) containing a single core motif half-site 5'-AGGTCA-3' preceded by a short A-T-rich sequence. Key regulator of cellular differentiation, immunity, peripheral circadian rhythm as well as lipid, steroid, xenobiotics and glucose metabolism . Considered to have intrinsic transcriptional activity, have some natural ligands like oxysterols that act as agonists (25-hydroxycholesterol) or inverse agonists (7-oxygenated sterols), enhancing or repressing the transcriptional activity, respectively . Recruits distinct combinations of cofactors to target gene regulatory regions to modulate their transcriptional expression, depending on the tissue, time and promoter contexts. Regulates the circadian expression of clock genes such as CRY1, BMAL1 and NR1D1 in peripheral tissues and in a tissue-selective manner. Competes with NR1D1 for binding to their shared DNA response element on some clock genes such as BMAL1, CRY1 and NR1D1 itself, resulting in NR1D1-mediated repression or RORC-mediated activation of the expression, leading to the circadian pattern of clock genes expression. Therefore influences the period length and stability of the clock. Involved in the regulation of the rhythmic expression of genes involved in glucose and lipid metabolism, including PLIN2 and AVPR1A . Negative regulator of adipocyte differentiation through the regulation of early phase genes expression, such as MMP3. Controls adipogenesis as well as adipocyte size and modulates insulin sensitivity in obesity. In liver, has specific and redundant functions with RORA as positive or negative modulator of expression of genes encoding phase I and Phase II proteins involved in the metabolism of lipids, steroids and xenobiotics, such as SULT1E1. Also plays a role in the regulation of hepatocyte glucose metabolism through the regulation of G6PC1 and PCK1 . Regulates the rhythmic expression of PROX1 and promotes its nuclear localization . Plays an indispensable role in the induction of IFN-gamma dependent anti-mycobacterial systemic immunity . .; FUNCTION: [Isoform 2]: Essential for thymopoiesis and the development of several secondary lymphoid tissues, including lymph nodes and Peyer's patches. Required for the generation of LTi (lymphoid tissue inducer) cells. Regulates thymocyte survival through DNA-binding on ROREs of target gene promoter regions and recruitment of coactivaros via the AF-2. Also plays a key role, downstream of IL6 and TGFB and synergistically with RORA, for lineage specification of uncommitted CD4(+) T-helper (T(H)) cells into T(H)17 cells, antagonizing the T(H)1 program. Probably regulates IL17 and IL17F expression on T(H) by binding to the essential enhancer conserved non-coding sequence 2 (CNS2) in the IL17-IL17F locus. May also play a role in the pre-TCR activation cascade leading to the maturation of alpha/beta T-cells and may participate in the regulation of DNA accessibility in the TCR-J(alpha) locus. .

AccessionsENST00000651814.1
ENST00000697811.1
ENST00000356728.11 [P51449-2]
A0A2K9REZ7
P51449
A0A494C0S6
A0A1W2PRM4
ENST00000652040.2
ENST00000638901.1
ENST00000318247.7 [P51449-1]
Q6I9R9
ENST00000651893.1
A0A8V8TL94
A0A494C174
A0A494C0H2