ESRRB report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0030518Biological processnuclear receptor-mediated steroid hormone signaling pathway
GO_0001892Biological processembryonic placenta development
GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_0045494Biological processphotoreceptor cell maintenance
GO_0017145Biological processstem cell division
GO_0043697Biological processcell dedifferentiation
GO_0048839Biological processinner ear development
GO_1902459Biological processpositive regulation of stem cell population maintenance
GO_0045893Biological processpositive regulation of DNA-templated transcription
GO_0019827Biological processstem cell population maintenance
GO_2000035Biological processregulation of stem cell division
GO_0006355Biological processregulation of DNA-templated transcription
GO_2000737Biological processnegative regulation of stem cell differentiation
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0032039Cellular componentintegrator complex
GO_0000793Cellular componentcondensed chromosome
GO_0000785Cellular componentchromatin
GO_0005634Cellular componentnucleus
GO_0000978Molecular functionRNA polymerase II cis-regulatory region sequence-specific DNA binding
GO_0001228Molecular functionDNA-binding transcription activator activity, RNA polymerase II-specific
GO_0000981Molecular functionDNA-binding transcription factor activity, RNA polymerase II-specific
GO_0000987Molecular functioncis-regulatory region sequence-specific DNA binding
GO_0043565Molecular functionsequence-specific DNA binding
GO_0003707Molecular functionnuclear steroid receptor activity
GO_0004879Molecular functionnuclear receptor activity
GO_1990837Molecular functionsequence-specific double-stranded DNA binding
GO_0034056Molecular functionestrogen response element binding
GO_0061629Molecular functionRNA polymerase II-specific DNA-binding transcription factor binding
GO_0000993Molecular functionRNA polymerase II complex binding
GO_0003700Molecular functionDNA-binding transcription factor activity
GO_0008270Molecular functionzinc ion binding
GO_0005496Molecular functionsteroid binding

IV. Literature review

[source]
Gene nameESRRB
Protein nameEstrogen related receptor beta
Steroid hormone receptor ERR2 (ERR beta-2) (Estrogen receptor-like 2) (Estrogen-related receptor beta) (ERR-beta) (Nuclear receptor subfamily 3 group B member 2)
SynonymsNR3B2
ERRB2
ESRL2
DescriptionFUNCTION: [Isoform 3]: Transcription factor that binds a canonical ESRRB recognition (ERRE) sequence 5'TCAAGGTCA-3' localized on promoter and enhancer of targets genes regulating their expression or their transcription activity . Plays a role, in a LIF-independent manner, in maintainance of self-renewal and pluripotency of embryonic and trophoblast stem cells through different signaling pathways including FGF signaling pathway and Wnt signaling pathways. Upon FGF signaling pathway activation, interacts with KDM1A by directly binding to enhancer site of ELF5 and EOMES and activating their transcription leading to self-renewal of trophoblast stem cells. Also regulates expression of multiple rod-specific genes and is required for survival of this cell type (By similarity). Plays a role as transcription factor activator of GATA6, NR0B1, POU5F1 and PERM1 . Plays a role as transcription factor repressor of NFE2L2 transcriptional activity and ESR1 transcriptional activity . During mitosis remains bound to a subset of interphase target genes, including pluripotency regulators, through the canonical ESRRB recognition (ERRE) sequence, leading to their transcriptional activation in early G1 phase. Can coassemble on structured DNA elements with other transcription factors like SOX2, POU5F1, KDM1A and NCOA3 to trigger ESRRB-dependent gene activation. This mechanism, in the case of SOX2 corecruitment prevents the embryonic stem cells (ESCs) to epiblast stem cells (EpiSC) transition through positive regulation of NR0B1 that inhibits the EpiSC transcriptional program. Also plays a role inner ear development by controlling expression of ion channels and transporters and in early placentation (By similarity). .; FUNCTION: [Isoform 1]: Transcription factor that binds a canonical ESRRB recognition (ERRE) sequence 5'TCAAGGTCA-3' localized on promoter and enhancer of targets genes regulating their expression or their transcription activity. Positively regulates ESR1 transcriptional activity upon E2 stimulation. .

AccessionsENST00000509242.5 [O95718-1]
A0A2R8Y509
ENST00000512784.6
ENST00000505752.6 [O95718-2]
ENST00000509323.1
A0A2R8Y491
O95718
E7EWD9
ENST00000644823.1
ENST00000380887.7 [O95718-1]