NR1D2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0097009Biological processenergy homeostasis
GO_0030522Biological processintracellular receptor signaling pathway
GO_0019216Biological processregulation of lipid metabolic process
GO_2001014Biological processregulation of skeletal muscle cell differentiation
GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_0050727Biological processregulation of inflammatory response
GO_0042752Biological processregulation of circadian rhythm
GO_0050728Biological processnegative regulation of inflammatory response
GO_0045893Biological processpositive regulation of DNA-templated transcription
GO_0030154Biological processcell differentiation
GO_0006355Biological processregulation of DNA-templated transcription
GO_0009755Biological processhormone-mediated signaling pathway
GO_0048512Biological processcircadian behavior
GO_0055088Biological processlipid homeostasis
GO_0045892Biological processnegative regulation of DNA-templated transcription
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0005654Cellular componentnucleoplasm
GO_0005737Cellular componentcytoplasm
GO_0000785Cellular componentchromatin
GO_0005634Cellular componentnucleus
GO_0000978Molecular functionRNA polymerase II cis-regulatory region sequence-specific DNA binding
GO_0001227Molecular functionDNA-binding transcription repressor activity, RNA polymerase II-specific
GO_0000981Molecular functionDNA-binding transcription factor activity, RNA polymerase II-specific
GO_0004879Molecular functionnuclear receptor activity
GO_1990837Molecular functionsequence-specific double-stranded DNA binding
GO_0008270Molecular functionzinc ion binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameNR1D2
Protein nameNuclear receptor subfamily 1 group D member 2 (Orphan nuclear hormone receptor BD73) (Rev-erb alpha-related receptor) (RVR) (Rev-erb-beta) (V-erbA-related protein 1-related) (EAR-1R)
NR1D2 protein (Nuclear receptor subfamily 1 group D member 2)
Nuclear receptor subfamily 1, group D, member 2
Nuclear receptor Rev-ErbA beta variant 2 (Nuclear receptor subfamily 1, group D, member 2, isoform CRA_b) (cDNA FLJ51368, highly similar to Orphan nuclear receptor NR1D2)
Nuclear receptor Rev-ErbA beta variant 1
NR1D2 protein
SynonymshCG_1778084
DescriptionFUNCTION: Transcriptional repressor which coordinates circadian rhythm and metabolic pathways in a heme-dependent manner. Integral component of the complex transcription machinery that governs circadian rhythmicity and forms a critical negative limb of the circadian clock by directly repressing the expression of core clock components BMAL1 and CLOCK. Also regulates genes involved in metabolic functions, including lipid metabolism and the inflammatory response. Acts as a receptor for heme which stimulates its interaction with the NCOR1/HDAC3 corepressor complex, enhancing transcriptional repression. Recognizes two classes of DNA response elements within the promoter of its target genes and can bind to DNA as either monomers or homodimers, depending on the nature of the response element. Binds as a monomer to a response element composed of the consensus half-site motif 5'-[A/G]GGTCA-3' preceded by an A/T-rich 5' sequence (RevRE), or as a homodimer to a direct repeat of the core motif spaced by two nuclegotides (RevDR-2). Acts as a potent competitive repressor of ROR alpha (RORA) function and also negatively regulates the expression of NR1D1. Regulates lipid and energy homeostasis in the skeletal muscle via repression of genes involved in lipid metabolism and myogenesis including: CD36, FABP3, FABP4, UCP3, SCD1 and MSTN. Regulates hepatic lipid metabolism via the repression of APOC3. Represses gene expression at a distance in macrophages by inhibiting the transcription of enhancer-derived RNAs (eRNAs). In addition to its activity as a repressor, can also act as a transcriptional activator. Acts as a transcriptional activator of the sterol regulatory element-binding protein 1 (SREBF1) and the inflammatory mediator interleukin-6 (IL6) in the skeletal muscle (By similarity). Plays a role in the regulation of circadian sleep/wake cycle; essential for maintaining wakefulness during the dark phase or active period (By similarity). Key regulator of skeletal muscle mitochondrial function; negatively regulates the skeletal muscle expression of core clock genes and genes involved in mitochondrial biogenesis, fatty acid beta-oxidation and lipid metabolism (By similarity). May play a role in the circadian control of neutrophilic inflammation in the lung (By similarity). .

AccessionsENST00000312521.9
B6ZGS3
Q6I9S1
Q6NSM0
Q96B66
B4DXD3
Q14995
F1D8P2
ENST00000383773.8