RORB | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
astrocyte	14 studies	50% ± 21%	Explore
amacrine cell	8 studies	57% ± 22%	Explore
retinal rod cell	8 studies	42% ± 16%	Explore
retina horizontal cell	7 studies	95% ± 4%	Explore
retinal ganglion cell	7 studies	62% ± 22%	Explore
retinal cone cell	7 studies	42% ± 15%	Explore
glutamatergic neuron	7 studies	45% ± 16%	Explore
Mueller cell	6 studies	74% ± 13%	Explore
retinal bipolar neuron	5 studies	43% ± 20%	Explore
fibroblast	4 studies	36% ± 8%	Explore
OFF-bipolar cell	4 studies	44% ± 26%	Explore
ON-bipolar cell	4 studies	59% ± 17%	Explore
neuron	3 studies	23% ± 7%	Explore
retinal pigment epithelial cell	3 studies	46% ± 10%	Explore
GABAergic amacrine cell	3 studies	70% ± 17%	Explore
glycinergic amacrine cell	3 studies	77% ± 15%	Explore
rod bipolar cell	3 studies	33% ± 5%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
eye	9 studies	47% ± 19%	Explore
brain	8 studies	31% ± 12%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
brain	94%	1605.86	2479 / 2642	93%	9.31	658 / 705
prostate	98%	1105.91	240 / 245	88%	7.97	441 / 502
adrenal gland	99%	659.52	256 / 258	61%	4.64	141 / 230
uterus	49%	393.34	83 / 170	19%	0.77	86 / 459
heart	63%	205.61	545 / 861	0%	0	0 / 0
bladder	57%	337.95	12 / 21	6%	0.23	31 / 504
breast	46%	133.18	212 / 459	17%	0.62	188 / 1118
tonsil	0%	0	0 / 0	62%	7.53	28 / 45
lung	43%	158.28	249 / 578	17%	0.47	196 / 1155
blood vessel	59%	636.65	784 / 1335	0%	0	0 / 0
adipose	56%	182.59	680 / 1204	0%	0	0 / 0
thymus	45%	93.04	291 / 653	11%	0.30	64 / 605
esophagus	20%	45.82	296 / 1445	10%	0.36	19 / 183
ovary	29%	83.95	52 / 180	2%	0.05	8 / 430
skin	19%	60.29	338 / 1809	12%	0.36	55 / 472
stomach	21%	49.55	74 / 359	8%	0.12	22 / 286
intestine	23%	49.31	221 / 966	3%	0.05	15 / 527
pancreas	2%	3.09	6 / 328	15%	0.25	26 / 178
eye	0%	0	0 / 0	13%	0.60	10 / 80
kidney	8%	16.36	7 / 89	4%	0.26	37 / 901
lymph node	0%	0	0 / 0	3%	0.10	1 / 29
liver	0%	1.56	1 / 226	1%	0.04	5 / 406
muscle	0%	0.49	2 / 803	0%	0	0 / 0
peripheral blood	0%	0.72	2 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
spleen	0%	0	0 / 241	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

III. Associated gene sets

GO_0071300	Biological process	cellular response to retinoic acid
GO_0007601	Biological process	visual perception
GO_0046548	Biological process	retinal rod cell development
GO_0006357	Biological process	regulation of transcription by RNA polymerase II
GO_0030522	Biological process	intracellular receptor signaling pathway
GO_0060041	Biological process	retina development in camera-type eye
GO_0042752	Biological process	regulation of circadian rhythm
GO_0042462	Biological process	eye photoreceptor cell development
GO_0046549	Biological process	retinal cone cell development
GO_0007186	Biological process	G protein-coupled receptor signaling pathway
GO_0045893	Biological process	positive regulation of DNA-templated transcription
GO_0045668	Biological process	negative regulation of osteoblast differentiation
GO_0006355	Biological process	regulation of DNA-templated transcription
GO_0048511	Biological process	rhythmic process
GO_0045892	Biological process	negative regulation of DNA-templated transcription
GO_0035881	Biological process	amacrine cell differentiation
GO_0045944	Biological process	positive regulation of transcription by RNA polymerase II
GO_0005654	Cellular component	nucleoplasm
GO_0000785	Cellular component	chromatin
GO_0005634	Cellular component	nucleus
GO_0000978	Molecular function	RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO_0001228	Molecular function	DNA-binding transcription activator activity, RNA polymerase II-specific
GO_0000981	Molecular function	DNA-binding transcription factor activity, RNA polymerase II-specific
GO_0004879	Molecular function	nuclear receptor activity
GO_1990837	Molecular function	sequence-specific double-stranded DNA binding
GO_0003700	Molecular function	DNA-binding transcription factor activity
GO_0008270	Molecular function	zinc ion binding
GO_0008502	Molecular function	melatonin receptor activity
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	RORB
Protein name	RAR related orphan receptor B isoform 1 (RAR-related orphan receptor B) (cDNA, FLJ93970, Homo sapiens RAR-related orphan receptor B (RORB), mRNA) RAR related orphan receptor B isoform 2 Nuclear receptor ROR-beta (Nuclear receptor RZR-beta) (Nuclear receptor subfamily 1 group F member 2) (Retinoid-related orphan receptor-beta)
Synonyms	hCG_27313 ROR-BETA NR1F2 RZRB
Description	FUNCTION: Nuclear receptor that binds DNA as a monomer to ROR response elements (RORE) containing a single core motif half-site 5'-AGGTCA-3' preceded by a short A-T-rich sequence. Considered to have intrinsic transcriptional activity, have some natural ligands such as all-trans retinoic acid (ATRA) and other retinoids which act as inverse agonists repressing the transcriptional activity. Required for normal postnatal development of rod and cone photoreceptor cells. Modulates rod photoreceptors differentiation at least by inducing the transcription factor NRL-mediated pathway. In cone photoreceptor cells, regulates transcription of OPN1SW. Involved in the regulation of the period length and stability of the circadian rhythm. May control cytoarchitectural patterning of neocortical neurons during development. May act in a dose-dependent manner to regulate barrel formation upon innervation of layer IV neurons by thalamocortical axons. May play a role in the suppression of osteoblastic differentiation through the inhibition of RUNX2 transcriptional activity (By similarity). .; FUNCTION: Isoform 1 is critical for hindlimb motor control and for the differentiation of amacrine and horizontal cells in the retina. Regulates the expression of PTF1A synergistically with FOXN4 (By similarity). .
Accessions	Q58EY0 A0A1L4FMK7 ENST00000376896.8 [Q92753-1] Q92753 ENST00000396204.2 [Q92753-2]

RORB report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review