THRA | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
endothelial cell	9 studies	25% ± 9%	Explore
smooth muscle cell	8 studies	21% ± 5%	Explore
glutamatergic neuron	8 studies	31% ± 18%	Explore
astrocyte	8 studies	26% ± 9%	Explore
oligodendrocyte	8 studies	25% ± 8%	Explore
fibroblast	7 studies	23% ± 4%	Explore
amacrine cell	5 studies	41% ± 17%	Explore
oligodendrocyte precursor cell	5 studies	29% ± 11%	Explore
myofibroblast cell	4 studies	23% ± 6%	Explore
epithelial cell	4 studies	27% ± 11%	Explore
GABAergic neuron	4 studies	39% ± 8%	Explore
pericyte	4 studies	19% ± 3%	Explore
connective tissue cell	4 studies	19% ± 4%	Explore
interneuron	4 studies	38% ± 16%	Explore
retinal bipolar neuron	3 studies	25% ± 6%	Explore
retina horizontal cell	3 studies	32% ± 10%	Explore
neuron	3 studies	37% ± 14%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
brain	11 studies	27% ± 12%	Explore
intestine	4 studies	21% ± 6%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
brain	100%	21070.77	2642 / 2642	100%	184.26	703 / 705
intestine	100%	8035.65	965 / 966	98%	36.18	519 / 527
skin	100%	5729.50	1804 / 1809	98%	28.51	464 / 472
stomach	99%	5882.03	357 / 359	98%	42.15	281 / 286
prostate	98%	4940.12	241 / 245	99%	25.04	498 / 502
thymus	99%	4395.95	646 / 653	99%	28.80	596 / 605
adrenal gland	98%	5967.71	254 / 258	98%	44.09	225 / 230
ovary	100%	8689.95	180 / 180	96%	22.21	413 / 430
breast	100%	6176.39	458 / 459	95%	24.48	1061 / 1118
kidney	94%	3833.20	84 / 89	97%	29.59	878 / 901
lung	98%	4974.71	567 / 578	92%	18.18	1057 / 1155
esophagus	92%	5801.18	1324 / 1445	95%	30.12	173 / 183
uterus	100%	8282.90	170 / 170	83%	18.43	381 / 459
pancreas	80%	2277.31	264 / 328	98%	26.62	174 / 178
bladder	100%	6314.10	21 / 21	73%	15.43	366 / 504
eye	0%	0	0 / 0	100%	43.99	80 / 80
ureter	0%	0	0 / 0	100%	10.51	1 / 1
blood vessel	100%	8626.21	1333 / 1335	0%	0	0 / 0
adipose	100%	6273.55	1200 / 1204	0%	0	0 / 0
muscle	100%	6210.57	800 / 803	0%	0	0 / 0
heart	92%	4933.01	793 / 861	0%	0	0 / 0
spleen	80%	2049.54	193 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	80%	12.98	36 / 45
liver	3%	77.53	7 / 226	49%	6.95	197 / 406
lymph node	0%	0	0 / 0	24%	1.90	7 / 29
peripheral blood	7%	149.78	69 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0006366	Biological process	transcription by RNA polymerase II
GO_0033032	Biological process	regulation of myeloid cell apoptotic process
GO_2000143	Biological process	negative regulation of DNA-templated transcription initiation
GO_0045925	Biological process	positive regulation of female receptivity
GO_0007611	Biological process	learning or memory
GO_0017055	Biological process	negative regulation of RNA polymerase II transcription preinitiation complex assembly
GO_0006357	Biological process	regulation of transcription by RNA polymerase II
GO_0030878	Biological process	thyroid gland development
GO_0000122	Biological process	negative regulation of transcription by RNA polymerase II
GO_0060509	Biological process	type I pneumocyte differentiation
GO_0030218	Biological process	erythrocyte differentiation
GO_0050994	Biological process	regulation of lipid catabolic process
GO_0030154	Biological process	cell differentiation
GO_0008050	Biological process	female courtship behavior
GO_0009409	Biological process	response to cold
GO_0120162	Biological process	positive regulation of cold-induced thermogenesis
GO_0009755	Biological process	hormone-mediated signaling pathway
GO_0002154	Biological process	thyroid hormone receptor signaling pathway
GO_0001503	Biological process	ossification
GO_0048384	Biological process	retinoic acid receptor signaling pathway
GO_0001502	Biological process	cartilage condensation
GO_0008016	Biological process	regulation of heart contraction
GO_0045892	Biological process	negative regulation of DNA-templated transcription
GO_0002155	Biological process	regulation of thyroid hormone receptor signaling pathway
GO_0045944	Biological process	positive regulation of transcription by RNA polymerase II
GO_0005654	Cellular component	nucleoplasm
GO_0090575	Cellular component	RNA polymerase II transcription regulator complex
GO_0005829	Cellular component	cytosol
GO_0000785	Cellular component	chromatin
GO_0005634	Cellular component	nucleus
GO_0017025	Molecular function	TBP-class protein binding
GO_0000978	Molecular function	RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO_0019904	Molecular function	protein domain specific binding
GO_0000981	Molecular function	DNA-binding transcription factor activity, RNA polymerase II-specific
GO_0000976	Molecular function	transcription cis-regulatory region binding
GO_0004879	Molecular function	nuclear receptor activity
GO_0003700	Molecular function	DNA-binding transcription factor activity
GO_0008270	Molecular function	zinc ion binding
GO_0070324	Molecular function	thyroid hormone binding
GO_0140296	Molecular function	general transcription initiation factor binding
GO_0031490	Molecular function	chromatin DNA binding
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	THRA
Protein name	Thyroid hormone receptor alpha Thyroid hormone receptor alpha (Nuclear receptor subfamily 1 group A member 1) (V-erbA-related protein 7) (EAR-7) (c-erbA-1) (c-erbA-alpha) Thyroid hormone receptor alpha (Nuclear receptor subfamily 1 group A member 1)
Synonyms	THRA2 NR1A1 THRA1 ERBA1 EAR7 hCG_1749555
Description	FUNCTION: [Isoform Alpha-1]: Nuclear hormone receptor that can act as a repressor or activator of transcription. High affinity receptor for thyroid hormones, including triiodothyronine and thyroxine. .; FUNCTION: [Isoform Alpha-2]: Does not bind thyroid hormone and functions as a weak dominant negative inhibitor of thyroid hormone action. .
Accessions	A0A0R5RI47 A0A0R5RI44 J3QRA9 ENST00000585047.5 J3QR26 ENST00000394121.8 [P10827-1] ENST00000577288.5 ENST00000450525.7 [P10827-2] J3QRW5 ENST00000578218.5 A0A0R5RI63 Q6FH41 P10827 ENST00000577486.1 ENST00000264637.8 [P10827-1] A0A0R5RI31 ENST00000546243.5 [P10827-2] ENST00000584985.5 [P10827-3] A0A0R5RI36 J3KTF3

THRA report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review