Name | Number of supported studies | Average coverage | |
---|---|---|---|
endothelial cell | 13 studies | 28% ± 12% | |
oligodendrocyte | 10 studies | 31% ± 11% | |
oligodendrocyte precursor cell | 9 studies | 27% ± 12% | |
microglial cell | 7 studies | 28% ± 8% | |
GABAergic neuron | 7 studies | 36% ± 18% | |
astrocyte | 7 studies | 32% ± 12% | |
interneuron | 6 studies | 37% ± 22% | |
macrophage | 6 studies | 31% ± 7% | |
glutamatergic neuron | 5 studies | 48% ± 20% | |
endothelial cell of lymphatic vessel | 5 studies | 25% ± 7% | |
fibroblast | 5 studies | 24% ± 6% | |
pericyte | 4 studies | 19% ± 6% | |
smooth muscle cell | 4 studies | 18% ± 1% | |
neuron | 3 studies | 36% ± 11% | |
epithelial cell | 3 studies | 31% ± 15% | |
cardiac muscle cell | 3 studies | 17% ± 1% | |
retinal rod cell | 3 studies | 17% ± 1% | |
dendritic cell | 3 studies | 18% ± 3% | |
T cell | 3 studies | 18% ± 1% | |
alveolar macrophage | 3 studies | 21% ± 6% | |
club cell | 3 studies | 22% ± 7% | |
monocyte | 3 studies | 22% ± 2% | |
type I pneumocyte | 3 studies | 20% ± 4% | |
type II pneumocyte | 3 studies | 19% ± 4% | |
lymphocyte | 3 studies | 26% ± 8% | |
adipocyte | 3 studies | 19% ± 4% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
esophagus | 100% | 4316.89 | 1443 / 1445 | 100% | 16.73 | 183 / 183 |
intestine | 100% | 5446.94 | 966 / 966 | 98% | 10.54 | 519 / 527 |
lung | 100% | 5486.84 | 578 / 578 | 98% | 12.03 | 1137 / 1155 |
stomach | 100% | 3426.80 | 358 / 359 | 98% | 12.17 | 279 / 286 |
brain | 98% | 3642.02 | 2582 / 2642 | 99% | 18.92 | 695 / 705 |
breast | 100% | 4684.84 | 459 / 459 | 96% | 14.05 | 1070 / 1118 |
skin | 100% | 4284.64 | 1809 / 1809 | 95% | 13.95 | 450 / 472 |
ovary | 100% | 5813.03 | 180 / 180 | 95% | 11.17 | 408 / 430 |
thymus | 100% | 8744.12 | 653 / 653 | 94% | 13.82 | 567 / 605 |
bladder | 100% | 4564.90 | 21 / 21 | 94% | 10.26 | 472 / 504 |
pancreas | 100% | 2306.63 | 327 / 328 | 93% | 9.75 | 166 / 178 |
kidney | 100% | 3605.15 | 89 / 89 | 93% | 9.93 | 834 / 901 |
prostate | 100% | 4742.50 | 245 / 245 | 89% | 10.04 | 448 / 502 |
adrenal gland | 100% | 3141.23 | 258 / 258 | 87% | 10.79 | 200 / 230 |
uterus | 100% | 5775.20 | 170 / 170 | 87% | 9.13 | 398 / 459 |
liver | 100% | 2188.36 | 226 / 226 | 59% | 3.65 | 239 / 406 |
adipose | 100% | 4392.50 | 1204 / 1204 | 0% | 0 | 0 / 0 |
blood vessel | 100% | 4485.29 | 1335 / 1335 | 0% | 0 | 0 / 0 |
muscle | 100% | 3319.54 | 803 / 803 | 0% | 0 | 0 / 0 |
spleen | 100% | 5276.15 | 241 / 241 | 0% | 0 | 0 / 0 |
heart | 97% | 2951.80 | 838 / 861 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 87% | 11.61 | 39 / 45 |
peripheral blood | 85% | 2337.73 | 789 / 929 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 78% | 5.80 | 62 / 80 |
lymph node | 0% | 0 | 0 / 0 | 59% | 7.71 | 17 / 29 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
GO_0007283 | Biological process | spermatogenesis |
GO_0030522 | Biological process | intracellular receptor signaling pathway |
GO_0000122 | Biological process | negative regulation of transcription by RNA polymerase II |
GO_0040019 | Biological process | positive regulation of embryonic development |
GO_0030154 | Biological process | cell differentiation |
GO_0006355 | Biological process | regulation of DNA-templated transcription |
GO_0048856 | Biological process | anatomical structure development |
GO_0007399 | Biological process | nervous system development |
GO_0045944 | Biological process | positive regulation of transcription by RNA polymerase II |
GO_0005654 | Cellular component | nucleoplasm |
GO_0000785 | Cellular component | chromatin |
GO_0000978 | Molecular function | RNA polymerase II cis-regulatory region sequence-specific DNA binding |
GO_0001228 | Molecular function | DNA-binding transcription activator activity, RNA polymerase II-specific |
GO_0000977 | Molecular function | RNA polymerase II transcription regulatory region sequence-specific DNA binding |
GO_0000981 | Molecular function | DNA-binding transcription factor activity, RNA polymerase II-specific |
GO_0043565 | Molecular function | sequence-specific DNA binding |
GO_0004879 | Molecular function | nuclear receptor activity |
GO_1990837 | Molecular function | sequence-specific double-stranded DNA binding |
GO_0003700 | Molecular function | DNA-binding transcription factor activity |
GO_0008270 | Molecular function | zinc ion binding |
GO_0005515 | Molecular function | protein binding |
Gene name | NR2C2 |
Protein name | Nuclear receptor subfamily 2, group C, member 2, isoform CRA_a (Testicular nuclear receptor 4) Nuclear receptor subfamily 2 group C member 2 (Orphan nuclear receptor TAK1) (Orphan nuclear receptor TR4) (Testicular receptor 4) NR2C2 protein Nuclear receptor subfamily 2 group C member 2 |
Synonyms | hCG_27821 TAK1 TR4 |
Description | FUNCTION: Orphan nuclear receptor that can act as a repressor or activator of transcription. An important repressor of nuclear receptor signaling pathways such as retinoic acid receptor, retinoid X, vitamin D3 receptor, thyroid hormone receptor and estrogen receptor pathways. May regulate gene expression during the late phase of spermatogenesis. Together with NR2C1, forms the core of the DRED (direct repeat erythroid-definitive) complex that represses embryonic and fetal globin transcription including that of GATA1. Binds to hormone response elements (HREs) consisting of two 5'-AGGTCA-3' half site direct repeat consensus sequences. Plays a fundamental role in early embryonic development and embryonic stem cells. Required for normal spermatogenesis and cerebellum development. Appears to be important for neurodevelopmentally regulated behavior (By similarity). Activates transcriptional activity of LHCG. Antagonist of PPARA-mediated transactivation. . |
Accessions | ENST00000435454.5 ENST00000437120.5 ENST00000393102.7 [P49116-1] H7C3L1 ENST00000425241.6 [P49116-1] ENST00000617312.4 [P49116-2] H7C3R1 ENST00000413118.5 ENST00000413194.1 P49116 ENST00000323373.10 [P49116-2] C9JKS0 F2YGU2 C9JMI6 ENST00000439011.5 Q6PHZ7 C9J2Y1 ENST00000406272.6 [P49116-1] |