NR2C2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0007283Biological processspermatogenesis
GO_0030522Biological processintracellular receptor signaling pathway
GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_0040019Biological processpositive regulation of embryonic development
GO_0030154Biological processcell differentiation
GO_0006355Biological processregulation of DNA-templated transcription
GO_0048856Biological processanatomical structure development
GO_0007399Biological processnervous system development
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0005654Cellular componentnucleoplasm
GO_0000785Cellular componentchromatin
GO_0000978Molecular functionRNA polymerase II cis-regulatory region sequence-specific DNA binding
GO_0001228Molecular functionDNA-binding transcription activator activity, RNA polymerase II-specific
GO_0000977Molecular functionRNA polymerase II transcription regulatory region sequence-specific DNA binding
GO_0000981Molecular functionDNA-binding transcription factor activity, RNA polymerase II-specific
GO_0043565Molecular functionsequence-specific DNA binding
GO_0004879Molecular functionnuclear receptor activity
GO_1990837Molecular functionsequence-specific double-stranded DNA binding
GO_0003700Molecular functionDNA-binding transcription factor activity
GO_0008270Molecular functionzinc ion binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameNR2C2
Protein nameNuclear receptor subfamily 2, group C, member 2, isoform CRA_a (Testicular nuclear receptor 4)
Nuclear receptor subfamily 2 group C member 2 (Orphan nuclear receptor TAK1) (Orphan nuclear receptor TR4) (Testicular receptor 4)
NR2C2 protein
Nuclear receptor subfamily 2 group C member 2
SynonymshCG_27821
TAK1
TR4
DescriptionFUNCTION: Orphan nuclear receptor that can act as a repressor or activator of transcription. An important repressor of nuclear receptor signaling pathways such as retinoic acid receptor, retinoid X, vitamin D3 receptor, thyroid hormone receptor and estrogen receptor pathways. May regulate gene expression during the late phase of spermatogenesis. Together with NR2C1, forms the core of the DRED (direct repeat erythroid-definitive) complex that represses embryonic and fetal globin transcription including that of GATA1. Binds to hormone response elements (HREs) consisting of two 5'-AGGTCA-3' half site direct repeat consensus sequences. Plays a fundamental role in early embryonic development and embryonic stem cells. Required for normal spermatogenesis and cerebellum development. Appears to be important for neurodevelopmentally regulated behavior (By similarity). Activates transcriptional activity of LHCG. Antagonist of PPARA-mediated transactivation. .

AccessionsENST00000435454.5
ENST00000437120.5
ENST00000393102.7 [P49116-1]
H7C3L1
ENST00000425241.6 [P49116-1]
ENST00000617312.4 [P49116-2]
H7C3R1
ENST00000413118.5
ENST00000413194.1
P49116
ENST00000323373.10 [P49116-2]
C9JKS0
F2YGU2
C9JMI6
ENST00000439011.5
Q6PHZ7
C9J2Y1
ENST00000406272.6 [P49116-1]