RXRA report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0035357Biological processperoxisome proliferator activated receptor signaling pathway
GO_0002157Biological processpositive regulation of thyroid hormone receptor signaling pathway
GO_0070564Biological processpositive regulation of vitamin D receptor signaling pathway
GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_0045893Biological processpositive regulation of DNA-templated transcription
GO_0030154Biological processcell differentiation
GO_0010875Biological processpositive regulation of cholesterol efflux
GO_0009755Biological processhormone-mediated signaling pathway
GO_0043401Biological processsteroid hormone receptor signaling pathway
GO_0042789Biological processmRNA transcription by RNA polymerase II
GO_0032526Biological processresponse to retinoic acid
GO_0032411Biological processpositive regulation of transporter activity
GO_0048856Biological processanatomical structure development
GO_0048384Biological processretinoic acid receptor signaling pathway
GO_0030501Biological processpositive regulation of bone mineralization
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0043235Cellular componentreceptor complex
GO_0005739Cellular componentmitochondrion
GO_0005654Cellular componentnucleoplasm
GO_0090575Cellular componentRNA polymerase II transcription regulator complex
GO_0005829Cellular componentcytosol
GO_0000785Cellular componentchromatin
GO_0005667Cellular componenttranscription regulator complex
GO_0005634Cellular componentnucleus
GO_0019899Molecular functionenzyme binding
GO_0000978Molecular functionRNA polymerase II cis-regulatory region sequence-specific DNA binding
GO_0000977Molecular functionRNA polymerase II transcription regulatory region sequence-specific DNA binding
GO_0050693Molecular functionLBD domain binding
GO_0000981Molecular functionDNA-binding transcription factor activity, RNA polymerase II-specific
GO_0043565Molecular functionsequence-specific DNA binding
GO_0003707Molecular functionnuclear steroid receptor activity
GO_0000976Molecular functiontranscription cis-regulatory region binding
GO_0042277Molecular functionpeptide binding
GO_0003690Molecular functiondouble-stranded DNA binding
GO_0001221Molecular functiontranscription coregulator binding
GO_0004879Molecular functionnuclear receptor activity
GO_0070644Molecular functionvitamin D response element binding
GO_1990837Molecular functionsequence-specific double-stranded DNA binding
GO_0050692Molecular functionDNA binding domain binding
GO_0042802Molecular functionidentical protein binding
GO_0003700Molecular functionDNA-binding transcription factor activity
GO_0001972Molecular functionretinoic acid binding
GO_0008270Molecular functionzinc ion binding
GO_0044323Molecular functionretinoic acid-responsive element binding
GO_0042809Molecular functionnuclear vitamin D receptor binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameRXRA
Protein nameRetinoic acid receptor RXR (Nuclear receptor subfamily 2 group B member)
Retinoid X receptor alpha
Retinoic acid receptor RXR-alpha (Nuclear receptor subfamily 2 group B member 1) (Retinoid X receptor alpha)
SynonymsNR2B1
DescriptionFUNCTION: Receptor for retinoic acid that acts as a transcription factor . Forms homo- or heterodimers with retinoic acid receptors (RARs) and binds to target response elements in response to their ligands, all-trans or 9-cis retinoic acid, to regulate gene expression in various biological processes . The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5 to regulate transcription . The high affinity ligand for retinoid X receptors (RXRs) is 9-cis retinoic acid . In the absence of ligand, the RXR-RAR heterodimers associate with a multiprotein complex containing transcription corepressors that induce histone deacetylation, chromatin condensation and transcriptional suppression . On ligand binding, the corepressors dissociate from the receptors and coactivators are recruited leading to transcriptional activation . Serves as a common heterodimeric partner for a number of nuclear receptors, such as RARA, RARB and PPARA . The RXRA/RARB heterodimer can act as a transcriptional repressor or transcriptional activator, depending on the RARE DNA element context . The RXRA/PPARA heterodimer is required for PPARA transcriptional activity on fatty acid oxidation genes such as ACOX1 and the P450 system genes . Together with RARA, positively regulates microRNA-10a expression, thereby inhibiting the GATA6/VCAM1 signaling response to pulsatile shear stress in vascular endothelial cells . Acts as an enhancer of RARA binding to RARE DNA element . May facilitate the nuclear import of heterodimerization partners such as VDR and NR4A1 . Promotes myelin debris phagocytosis and remyelination by macrophages . Plays a role in the attenuation of the innate immune system in response to viral infections, possibly by negatively regulating the transcription of antiviral genes such as type I IFN genes . Involved in the regulation of calcium signaling by repressing ITPR2 gene expression, thereby controlling cellular senescence . .

FUNCTION: Receptor for retinoic acid that acts as a transcription factor. Forms homo- or heterodimers with retinoic acid receptors (rars) and binds to target response elements in response to their ligands, all-trans or 9-cis retinoic acid, to regulate gene expression in various biological processes. .

FUNCTION: Receptor for retinoic acid that acts as a transcription factor. Forms homo- or heterodimers with retinoic acid receptors (rars) and binds to target response elements in response to their ligands, all-trans or 9-cis retinoic acid, to regulate gene expression in various biological processes. .

AccessionsENST00000481739.2 [P19793-1]
P19793
A0A3B3IS44
ENST00000649020.1
Q6P3U7
ENST00000672570.1
A0A5F9ZHH6