NR1H2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0036151Biological processphosphatidylcholine acyl-chain remodeling
GO_0051247Biological processpositive regulation of protein metabolic process
GO_0010887Biological processnegative regulation of cholesterol storage
GO_0045723Biological processpositive regulation of fatty acid biosynthetic process
GO_0090187Biological processpositive regulation of pancreatic juice secretion
GO_0030522Biological processintracellular receptor signaling pathway
GO_0060336Biological processnegative regulation of type II interferon-mediated signaling pathway
GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_0010867Biological processpositive regulation of triglyceride biosynthetic process
GO_1903573Biological processnegative regulation of response to endoplasmic reticulum stress
GO_0042632Biological processcholesterol homeostasis
GO_0032376Biological processpositive regulation of cholesterol transport
GO_0048550Biological processnegative regulation of pinocytosis
GO_0010745Biological processnegative regulation of macrophage derived foam cell differentiation
GO_0090340Biological processpositive regulation of secretion of lysosomal enzymes
GO_0032369Biological processnegative regulation of lipid transport
GO_0090108Biological processpositive regulation of high-density lipoprotein particle assembly
GO_0045861Biological processnegative regulation of proteolysis
GO_0045893Biological processpositive regulation of DNA-templated transcription
GO_0030154Biological processcell differentiation
GO_1902895Biological processpositive regulation of miRNA transcription
GO_0010875Biological processpositive regulation of cholesterol efflux
GO_0009755Biological processhormone-mediated signaling pathway
GO_0042789Biological processmRNA transcription by RNA polymerase II
GO_0051006Biological processpositive regulation of lipoprotein lipase activity
GO_0010884Biological processpositive regulation of lipid storage
GO_0045892Biological processnegative regulation of DNA-templated transcription
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0120163Biological processnegative regulation of cold-induced thermogenesis
GO_0005654Cellular componentnucleoplasm
GO_0090575Cellular componentRNA polymerase II transcription regulator complex
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0000785Cellular componentchromatin
GO_0005634Cellular componentnucleus
GO_0003677Molecular functionDNA binding
GO_0000978Molecular functionRNA polymerase II cis-regulatory region sequence-specific DNA binding
GO_0034191Molecular functionapolipoprotein A-I receptor binding
GO_0001228Molecular functionDNA-binding transcription activator activity, RNA polymerase II-specific
GO_0000981Molecular functionDNA-binding transcription factor activity, RNA polymerase II-specific
GO_0004879Molecular functionnuclear receptor activity
GO_0046965Molecular functionnuclear retinoid X receptor binding
GO_0008270Molecular functionzinc ion binding
GO_0051117Molecular functionATPase binding
GO_0031490Molecular functionchromatin DNA binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameNR1H2
Protein nameLiver X nuclear receptor beta (Nuclear receptor subfamily 1, group H, member 2, isoform CRA_c)
Nuclear receptor subfamily 1 group H member 2
NR1H2 protein
Liver X receptor beta
Oxysterols receptor LXR-beta (Liver X receptor beta) (Nuclear receptor NER) (Nuclear receptor subfamily 1 group H member 2) (Ubiquitously-expressed nuclear receptor)
SynonymsNER
hCG_22944
UNR
LXRB
DescriptionFUNCTION: Nuclear receptor that exhibits a ligand-dependent transcriptional activation activity . Binds preferentially to double-stranded oligonucleotide direct repeats having the consensus half-site sequence 5'-AGGTCA-3' and 4-nt spacing (DR-4). Regulates cholesterol uptake through MYLIP-dependent ubiquitination of LDLR, VLDLR and LRP8; DLDLR and LRP8. Interplays functionally with RORA for the regulation of genes involved in liver metabolism (By similarity). Induces LPCAT3-dependent phospholipid remodeling in endoplasmic reticulum (ER) membranes of hepatocytes, driving SREBF1 processing and lipogenesis (By similarity). Via LPCAT3, triggers the incorporation of arachidonate into phosphatidylcholines of ER membranes, increasing membrane dynamics and enabling triacylglycerols transfer to nascent very low-density lipoprotein (VLDL) particles (By similarity). Via LPCAT3 also counteracts lipid-induced ER stress response and inflammation, likely by modulating SRC kinase membrane compartmentalization and limiting the synthesis of lipid inflammatory mediators (By similarity). Plays an anti-inflammatory role during the hepatic acute phase response by acting as a corepressor: inhibits the hepatic acute phase response by preventing dissociation of the N-Cor corepressor complex . .

AccessionsM0QYE6
M0R3A7
ENST00000593532.5
ENST00000597130.5
ENST00000652203.1 [P55055-1]
P55055
M0QZF5
M0R0K3
ENST00000599105.5
ENST00000600355.5
ENST00000411902.6 [P55055-2]
ENST00000253727.10 [P55055-1]
B6ZGS7
ENST00000598168.5
F1D8P7
ENST00000597157.1
ENST00000597790.5
M0R229
M0R2F9
M0R1V8
ENST00000593926.5 [P55055-1]
Q6IBU6