I. Expression across cell types
Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| retinal rod cell | 9 studies | 74% ± 15% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| retinal rod cell | 9 studies | 74% ± 15% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| eye | 6 studies | 42% ± 13% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| breast | 86% | 45.90 | 395 / 459 | 28% | 0.72 | 315 / 1118 |
| prostate | 100% | 117.93 | 244 / 245 | 13% | 0.22 | 65 / 502 |
| uterus | 98% | 32.35 | 167 / 170 | 7% | 0.13 | 33 / 459 |
| kidney | 99% | 29.25 | 88 / 89 | 6% | 0.10 | 53 / 901 |
| stomach | 100% | 48.24 | 358 / 359 | 1% | 0.02 | 4 / 286 |
| esophagus | 97% | 27.94 | 1397 / 1445 | 4% | 0.07 | 8 / 183 |
| thymus | 100% | 72.37 | 653 / 653 | 1% | 0.01 | 5 / 605 |
| lung | 99% | 35.21 | 573 / 578 | 2% | 0.03 | 18 / 1155 |
| bladder | 95% | 23.62 | 20 / 21 | 2% | 0.03 | 11 / 504 |
| ovary | 60% | 8.17 | 108 / 180 | 36% | 1.30 | 156 / 430 |
| adrenal gland | 95% | 23.70 | 244 / 258 | 1% | 0.03 | 3 / 230 |
| intestine | 95% | 20.33 | 914 / 966 | 1% | 0.02 | 4 / 527 |
| blood vessel | 94% | 27.32 | 1261 / 1335 | 0% | 0 | 0 / 0 |
| brain | 94% | 20.79 | 2473 / 2642 | 1% | 0.01 | 5 / 705 |
| liver | 89% | 20.74 | 201 / 226 | 2% | 0.05 | 10 / 406 |
| pancreas | 85% | 15.67 | 278 / 328 | 1% | 0.01 | 1 / 178 |
| spleen | 85% | 12.39 | 204 / 241 | 0% | 0 | 0 / 0 |
| skin | 81% | 16.38 | 1473 / 1809 | 0% | 0 | 0 / 472 |
| heart | 76% | 9.61 | 652 / 861 | 0% | 0 | 0 / 0 |
| adipose | 75% | 12.89 | 897 / 1204 | 0% | 0 | 0 / 0 |
| muscle | 65% | 8.00 | 524 / 803 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 5% | 1.10 | 4 / 80 |
| peripheral blood | 3% | 0.25 | 30 / 929 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 29 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 45 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0007601 | Biological process | visual perception |
| GO_0008285 | Biological process | negative regulation of cell population proliferation |
| GO_0007602 | Biological process | phototransduction |
| GO_0008283 | Biological process | cell population proliferation |
| GO_0007165 | Biological process | signal transduction |
| GO_0010628 | Biological process | positive regulation of gene expression |
| GO_0030522 | Biological process | intracellular receptor signaling pathway |
| GO_0060041 | Biological process | retina development in camera-type eye |
| GO_0000122 | Biological process | negative regulation of transcription by RNA polymerase II |
| GO_0042462 | Biological process | eye photoreceptor cell development |
| GO_0030154 | Biological process | cell differentiation |
| GO_0043401 | Biological process | steroid hormone receptor signaling pathway |
| GO_0048856 | Biological process | anatomical structure development |
| GO_0045944 | Biological process | positive regulation of transcription by RNA polymerase II |
| GO_0005654 | Cellular component | nucleoplasm |
| GO_0005667 | Cellular component | transcription regulator complex |
| GO_0005634 | Cellular component | nucleus |
| GO_0000978 | Molecular function | RNA polymerase II cis-regulatory region sequence-specific DNA binding |
| GO_0001228 | Molecular function | DNA-binding transcription activator activity, RNA polymerase II-specific |
| GO_0043565 | Molecular function | sequence-specific DNA binding |
| GO_0003707 | Molecular function | nuclear steroid receptor activity |
| GO_0004879 | Molecular function | nuclear receptor activity |
| GO_0008270 | Molecular function | zinc ion binding |
| GO_0005515 | Molecular function | protein binding |
| Gene name | NR2E3 |
| Protein name | Photoreceptor-specific nuclear receptor (Nuclear receptor subfamily 2 group E member 3) (Retina-specific nuclear receptor) Nuclear receptor subfamily 2, group E, member 3, isoform CRA_b (Photoreceptor cell-specific nuclear receptor variant 1) NR2E3 protein (Nuclear receptor subfamily 2 group E member 3) |
| Synonyms | PNR hCG_38793 RNR |
| Description | FUNCTION: Orphan nuclear receptor of retinal photoreceptor cells. Transcriptional factor that is an activator of rod development and repressor of cone development. Binds the promoter region of a number of rod- and cone-specific genes, including rhodopsin, M- and S-opsin and rod-specific phosphodiesterase beta subunit. Enhances rhodopsin expression. Represses M- and S-cone opsin expression. . |
| Accessions | Q9Y5X4 Q8IVZ9 F1D8Q9 ENST00000621098.1 [Q9Y5X4-2] ENST00000621736.4 ENST00000617575.5 [Q9Y5X4-1] |
