I. Expression across cell types
Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| retina horizontal cell | 5 studies | 35% ± 12% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| retina horizontal cell | 5 studies | 35% ± 12% |
Insufficient scRNA-seq data for expression of DRD2 at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| brain | 93% | 1815.55 | 2460 / 2642 | 70% | 2.68 | 497 / 705 |
| adrenal gland | 32% | 195.19 | 83 / 258 | 67% | 103.50 | 154 / 230 |
| prostate | 73% | 96.67 | 178 / 245 | 7% | 0.16 | 35 / 502 |
| breast | 54% | 151.09 | 248 / 459 | 18% | 1.06 | 197 / 1118 |
| uterus | 50% | 92.80 | 85 / 170 | 21% | 1.73 | 95 / 459 |
| intestine | 30% | 20.84 | 288 / 966 | 33% | 2.47 | 172 / 527 |
| ovary | 9% | 5.96 | 16 / 180 | 50% | 2.21 | 217 / 430 |
| skin | 45% | 54.81 | 816 / 1809 | 11% | 0.86 | 50 / 472 |
| kidney | 43% | 82.49 | 38 / 89 | 5% | 0.30 | 41 / 901 |
| stomach | 6% | 6.89 | 21 / 359 | 34% | 3.07 | 98 / 286 |
| esophagus | 25% | 30.13 | 358 / 1445 | 10% | 0.33 | 18 / 183 |
| muscle | 34% | 28.23 | 276 / 803 | 0% | 0 | 0 / 0 |
| bladder | 14% | 8.76 | 3 / 21 | 14% | 1.20 | 72 / 504 |
| lung | 6% | 4.73 | 32 / 578 | 13% | 0.72 | 154 / 1155 |
| eye | 0% | 0 | 0 / 0 | 18% | 0.59 | 14 / 80 |
| blood vessel | 17% | 19.08 | 227 / 1335 | 0% | 0 | 0 / 0 |
| pancreas | 4% | 3.16 | 13 / 328 | 10% | 1.06 | 18 / 178 |
| adipose | 12% | 8.62 | 145 / 1204 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 4% | 0.10 | 2 / 45 |
| liver | 1% | 0.64 | 2 / 226 | 0% | 0.02 | 2 / 406 |
| thymus | 0% | 1.72 | 2 / 653 | 1% | 0.03 | 4 / 605 |
| spleen | 0% | 0.22 | 1 / 241 | 0% | 0 | 0 / 0 |
| heart | 0% | 0.11 | 2 / 861 | 0% | 0 | 0 / 0 |
| peripheral blood | 0% | 0.33 | 1 / 929 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 29 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0002052 | Biological process | positive regulation of neuroblast proliferation |
| GO_0007628 | Biological process | adult walking behavior |
| GO_0021984 | Biological process | adenohypophysis development |
| GO_0007195 | Biological process | adenylate cyclase-inhibiting dopamine receptor signaling pathway |
| GO_0051823 | Biological process | regulation of synapse structural plasticity |
| GO_0002027 | Biological process | regulation of heart rate |
| GO_0007608 | Biological process | sensory perception of smell |
| GO_0060158 | Biological process | phospholipase C-activating dopamine receptor signaling pathway |
| GO_0046676 | Biological process | negative regulation of insulin secretion |
| GO_0001933 | Biological process | negative regulation of protein phosphorylation |
| GO_0001666 | Biological process | response to hypoxia |
| GO_0035094 | Biological process | response to nicotine |
| GO_1900273 | Biological process | positive regulation of long-term synaptic potentiation |
| GO_0035815 | Biological process | positive regulation of renal sodium excretion |
| GO_0043491 | Biological process | phosphatidylinositol 3-kinase/protein kinase B signal transduction |
| GO_0002031 | Biological process | G protein-coupled receptor internalization |
| GO_0001659 | Biological process | temperature homeostasis |
| GO_0006914 | Biological process | autophagy |
| GO_0009410 | Biological process | response to xenobiotic stimulus |
| GO_0070374 | Biological process | positive regulation of ERK1 and ERK2 cascade |
| GO_0032467 | Biological process | positive regulation of cytokinesis |
| GO_0007626 | Biological process | locomotory behavior |
| GO_0032228 | Biological process | regulation of synaptic transmission, GABAergic |
| GO_0050482 | Biological process | arachidonic acid secretion |
| GO_0051967 | Biological process | negative regulation of synaptic transmission, glutamatergic |
| GO_0050673 | Biological process | epithelial cell proliferation |
| GO_0014059 | Biological process | regulation of dopamine secretion |
| GO_0010039 | Biological process | response to iron ion |
| GO_0008285 | Biological process | negative regulation of cell population proliferation |
| GO_0042321 | Biological process | negative regulation of circadian sleep/wake cycle, sleep |
| GO_0043278 | Biological process | response to morphine |
| GO_0002028 | Biological process | regulation of sodium ion transport |
| GO_0060160 | Biological process | negative regulation of dopamine receptor signaling pathway |
| GO_0051584 | Biological process | regulation of dopamine uptake involved in synaptic transmission |
| GO_0042417 | Biological process | dopamine metabolic process |
| GO_0043266 | Biological process | regulation of potassium ion transport |
| GO_0021756 | Biological process | striatum development |
| GO_0050709 | Biological process | negative regulation of protein secretion |
| GO_0008542 | Biological process | visual learning |
| GO_0014854 | Biological process | response to inactivity |
| GO_0045824 | Biological process | negative regulation of innate immune response |
| GO_0042220 | Biological process | response to cocaine |
| GO_0043473 | Biological process | pigmentation |
| GO_0099171 | Biological process | presynaptic modulation of chemical synaptic transmission |
| GO_0030336 | Biological process | negative regulation of cell migration |
| GO_1990384 | Biological process | hyaloid vascular plexus regression |
| GO_0040018 | Biological process | positive regulation of multicellular organism growth |
| GO_2001223 | Biological process | negative regulation of neuron migration |
| GO_0007405 | Biological process | neuroblast proliferation |
| GO_0042756 | Biological process | drinking behavior |
| GO_0007194 | Biological process | negative regulation of adenylate cyclase activity |
| GO_0033602 | Biological process | negative regulation of dopamine secretion |
| GO_0051586 | Biological process | positive regulation of dopamine uptake involved in synaptic transmission |
| GO_0048169 | Biological process | regulation of long-term neuronal synaptic plasticity |
| GO_0021853 | Biological process | cerebral cortex GABAergic interneuron migration |
| GO_0060079 | Biological process | excitatory postsynaptic potential |
| GO_0021769 | Biological process | orbitofrontal cortex development |
| GO_0001976 | Biological process | nervous system process involved in regulation of systemic arterial blood pressure |
| GO_1901386 | Biological process | negative regulation of voltage-gated calcium channel activity |
| GO_0007409 | Biological process | axonogenesis |
| GO_0009416 | Biological process | response to light stimulus |
| GO_0001975 | Biological process | response to amphetamine |
| GO_0016055 | Biological process | Wnt signaling pathway |
| GO_0007416 | Biological process | synapse assembly |
| GO_0009636 | Biological process | response to toxic substance |
| GO_0030432 | Biological process | peristalsis |
| GO_0035810 | Biological process | positive regulation of urine volume |
| GO_0045944 | Biological process | positive regulation of transcription by RNA polymerase II |
| GO_0060124 | Biological process | positive regulation of growth hormone secretion |
| GO_0034776 | Biological process | response to histamine |
| GO_1900168 | Biological process | positive regulation of glial cell-derived neurotrophic factor production |
| GO_0007625 | Biological process | grooming behavior |
| GO_0031223 | Biological process | auditory behavior |
| GO_0071880 | Biological process | adenylate cyclase-activating adrenergic receptor signaling pathway |
| GO_0048149 | Biological process | behavioral response to ethanol |
| GO_0007616 | Biological process | long-term memory |
| GO_0048678 | Biological process | response to axon injury |
| GO_0051583 | Biological process | dopamine uptake involved in synaptic transmission |
| GO_0008306 | Biological process | associative learning |
| GO_0007270 | Biological process | neuron-neuron synaptic transmission |
| GO_0043410 | Biological process | positive regulation of MAPK cascade |
| GO_0051209 | Biological process | release of sequestered calcium ion into cytosol |
| GO_0050680 | Biological process | negative regulation of epithelial cell proliferation |
| GO_0002092 | Biological process | positive regulation of receptor internalization |
| GO_0032922 | Biological process | circadian regulation of gene expression |
| GO_0045745 | Biological process | positive regulation of G protein-coupled receptor signaling pathway |
| GO_0051898 | Biological process | negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction |
| GO_0090325 | Biological process | regulation of locomotion involved in locomotory behavior |
| GO_1900038 | Biological process | negative regulation of cellular response to hypoxia |
| GO_0045776 | Biological process | negative regulation of blood pressure |
| GO_0046717 | Biological process | acid secretion |
| GO_0099170 | Biological process | postsynaptic modulation of chemical synaptic transmission |
| GO_0008104 | Biological process | protein localization |
| GO_0048148 | Biological process | behavioral response to cocaine |
| GO_0048755 | Biological process | branching morphogenesis of a nerve |
| GO_0060134 | Biological process | prepulse inhibition |
| GO_0051481 | Biological process | negative regulation of cytosolic calcium ion concentration |
| GO_0098978 | Cellular component | glutamatergic synapse |
| GO_0001669 | Cellular component | acrosomal vesicle |
| GO_0030139 | Cellular component | endocytic vesicle |
| GO_0043679 | Cellular component | axon terminus |
| GO_0045211 | Cellular component | postsynaptic membrane |
| GO_0098691 | Cellular component | dopaminergic synapse |
| GO_0042734 | Cellular component | presynaptic membrane |
| GO_0030425 | Cellular component | dendrite |
| GO_0060170 | Cellular component | ciliary membrane |
| GO_0098982 | Cellular component | GABA-ergic synapse |
| GO_0097730 | Cellular component | non-motile cilium |
| GO_0097648 | Cellular component | G protein-coupled receptor complex |
| GO_0036126 | Cellular component | sperm flagellum |
| GO_0005886 | Cellular component | plasma membrane |
| GO_0043204 | Cellular component | perikaryon |
| GO_0000139 | Cellular component | Golgi membrane |
| GO_0005929 | Cellular component | cilium |
| GO_0016328 | Cellular component | lateral plasma membrane |
| GO_0030424 | Cellular component | axon |
| GO_0043197 | Cellular component | dendritic spine |
| GO_0030672 | Cellular component | synaptic vesicle membrane |
| GO_0001965 | Molecular function | G-protein alpha-subunit binding |
| GO_0042802 | Molecular function | identical protein binding |
| GO_0001591 | Molecular function | dopamine neurotransmitter receptor activity, coupled via Gi/Go |
| GO_1901363 | Molecular function | heterocyclic compound binding |
| GO_0035240 | Molecular function | dopamine binding |
| GO_0004930 | Molecular function | G protein-coupled receptor activity |
| GO_0005515 | Molecular function | protein binding |
| GO_0032795 | Molecular function | heterotrimeric G-protein binding |
| GO_0035255 | Molecular function | ionotropic glutamate receptor binding |
| Gene name | DRD2 |
| Protein name | Dopamine receptor D2 D(2) dopamine receptor (Dopamine D2 receptor) DRD2 Dopamine D2 receptor (Dopamine receptor D2) |
| Synonyms | |
| Description | FUNCTION: Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase . Positively regulates postnatal regression of retinal hyaloid vessels via suppression of VEGFR2/KDR activity, downstream of OPN5 (By similarity). . |
| Accessions | ENST00000362072.8 [P14416-1] ENST00000542616.1 ENST00000542968.5 [P14416-1] B5BUP4 P14416 ENST00000543292.1 A0A1Y8EK52 ENST00000538967.5 [P14416-3] ENST00000346454.7 [P14416-2] F8VUV1 ENST00000544518.5 Q6LDH7 A0A220XIT2 |
