ACE report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of ACE at tissue level.

III. Associated gene sets

GO_0001974Biological processblood vessel remodeling
GO_0003081Biological processregulation of systemic arterial blood pressure by renin-angiotensin
GO_0009792Biological processembryo development ending in birth or egg hatching
GO_0031100Biological processanimal organ regeneration
GO_0010608Biological processpost-transcriptional regulation of gene expression
GO_0060978Biological processangiogenesis involved in coronary vascular morphogenesis
GO_0071838Biological processcell proliferation in bone marrow
GO_0060218Biological processhematopoietic stem cell differentiation
GO_0002446Biological processneutrophil mediated immunity
GO_0010814Biological processsubstance P catabolic process
GO_0001666Biological processresponse to hypoxia
GO_0042755Biological processeating behavior
GO_0009410Biological processresponse to xenobiotic stimulus
GO_0042310Biological processvasoconstriction
GO_0042445Biological processhormone metabolic process
GO_0050482Biological processarachidonic acid secretion
GO_0002474Biological processantigen processing and presentation of peptide antigen via MHC class I
GO_0071333Biological processcellular response to glucose stimulus
GO_0010629Biological processnegative regulation of gene expression
GO_0008217Biological processregulation of blood pressure
GO_0001822Biological processkidney development
GO_0007565Biological processfemale pregnancy
GO_0042447Biological processhormone catabolic process
GO_0002003Biological processangiotensin maturation
GO_1904045Biological processcellular response to aldosterone
GO_0086091Biological processregulation of heart rate by cardiac conduction
GO_1903597Biological processnegative regulation of gap junction assembly
GO_0043171Biological processpeptide catabolic process
GO_0032943Biological processmononuclear cell proliferation
GO_0002019Biological processregulation of renal output by angiotensin
GO_0045907Biological processpositive regulation of vasoconstriction
GO_0097746Biological processblood vessel diameter maintenance
GO_0071548Biological processresponse to dexamethasone
GO_0006508Biological processproteolysis
GO_0008584Biological processmale gonad development
GO_0043065Biological processpositive regulation of apoptotic process
GO_0048286Biological processlung alveolus development
GO_1902033Biological processregulation of hematopoietic stem cell proliferation
GO_0007283Biological processspermatogenesis
GO_0060177Biological processregulation of angiotensin metabolic process
GO_0010815Biological processbradykinin catabolic process
GO_0050435Biological processamyloid-beta metabolic process
GO_0019229Biological processregulation of vasoconstriction
GO_0097066Biological processresponse to thyroid hormone
GO_2000170Biological processpositive regulation of peptidyl-cysteine S-nitrosylation
GO_0050769Biological processpositive regulation of neurogenesis
GO_0090281Biological processnegative regulation of calcium ion import
GO_0014910Biological processregulation of smooth muscle cell migration
GO_0031667Biological processresponse to nutrient levels
GO_0048167Biological processregulation of synaptic plasticity
GO_0003084Biological processpositive regulation of systemic arterial blood pressure
GO_0060047Biological processheart contraction
GO_0038166Biological processangiotensin-activated signaling pathway
GO_0034616Biological processresponse to laminar fluid shear stress
GO_0032496Biological processresponse to lipopolysaccharide
GO_0046325Biological processnegative regulation of glucose import
GO_0009925Cellular componentbasal plasma membrane
GO_0005768Cellular componentendosome
GO_0005576Cellular componentextracellular region
GO_0070062Cellular componentextracellular exosome
GO_0097225Cellular componentsperm midpiece
GO_0005615Cellular componentextracellular space
GO_0009897Cellular componentexternal side of plasma membrane
GO_0005886Cellular componentplasma membrane
GO_0005764Cellular componentlysosome
GO_0031526Cellular componentbrush border membrane
GO_0008270Molecular functionzinc ion binding
GO_0004175Molecular functionendopeptidase activity
GO_1901363Molecular functionheterocyclic compound binding
GO_0070573Molecular functionmetallodipeptidase activity
GO_0031711Molecular functionbradykinin receptor binding
GO_0005516Molecular functioncalmodulin binding
GO_0008238Molecular functionexopeptidase activity
GO_0008241Molecular functionpeptidyl-dipeptidase activity
GO_0008233Molecular functionpeptidase activity
GO_0031434Molecular functionmitogen-activated protein kinase kinase binding
GO_0031404Molecular functionchloride ion binding
GO_0004222Molecular functionmetalloendopeptidase activity
GO_0004180Molecular functioncarboxypeptidase activity
GO_0008240Molecular functiontripeptidyl-peptidase activity
GO_0008237Molecular functionmetallopeptidase activity
GO_0051019Molecular functionmitogen-activated protein kinase binding

IV. Literature review

[source]
Gene nameACE
Protein nameAngiotensin converting enzyme
Angiotensin I converting enzyme
Angiotensin-converting enzyme (EC 3.4.-.-)
Angiotensin-converting enzyme (ACE) (EC 3.4.15.1) (Dipeptidyl carboxypeptidase I) (Kininase II) (CD antigen CD143) [Cleaved into: Angiotensin-converting enzyme, soluble form]
Angiotensin-converting enzyme (EC 3.4.15.1) (Dipeptidyl carboxypeptidase I) (Kininase II)
SynonymsDCP
DCP1
DescriptionFUNCTION: Dipeptidyl carboxypeptidase that removes dipeptides from the C-terminus of a variety of circulating hormones, such as angiotensin I, bradykinin or enkephalins, thereby playing a key role in the regulation of blood pressure, electrolyte homeostasis or synaptic plasticity . Composed of two similar catalytic domains, each possessing a functional active site, with different selectivity for substrates . Plays a major role in the angiotensin-renin system that regulates blood pressure and sodium retention by the kidney by converting angiotensin I to angiotensin II, resulting in an increase of the vasoconstrictor activity of angiotensin . Also able to inactivate bradykinin, a potent vasodilator, and therefore enhance the blood pressure response . Acts as a regulator of synaptic transmission by mediating cleavage of neuropeptide hormones, such as substance P, neurotensin or enkephalins . Catalyzes degradation of different enkephalin neuropeptides (Met-enkephalin, Leu-enkephalin, Met-enkephalin-Arg-Phe and possibly Met-enkephalin-Arg-Gly-Leu) . Acts as a regulator of synaptic plasticity in the nucleus accumbens of the brain by mediating cleavage of Met-enkephalin-Arg-Phe, a strong ligand of Mu-type opioid receptor OPRM1, into Met-enkephalin (By similarity). Met-enkephalin-Arg-Phe cleavage by ACE decreases activation of OPRM1, leading to long-term synaptic potentiation of glutamate release (By similarity). Also acts as a regulator of hematopoietic stem cell differentiation by mediating degradation of hemoregulatory peptide N-acetyl-SDKP (AcSDKP) . Acts as a regulator of cannabinoid signaling pathway by mediating degradation of hemopressin, an antagonist peptide of the cannabinoid receptor CNR1 . Involved in amyloid-beta metabolism by catalyzing degradation of Amyloid-beta protein 40 and Amyloid-beta protein 42 peptides, thereby preventing plaque formation . Catalyzes cleavage of cholecystokinin (maturation of Cholecystokinin-8 and Cholecystokinin-5) and Gonadoliberin-1 (both maturation and degradation) hormones . Degradation of hemoregulatory peptide N-acetyl-SDKP (AcSDKP) and amyloid-beta proteins is mediated by the N-terminal catalytic domain, while angiotensin I and cholecystokinin cleavage is mediated by the C-terminal catalytic region . .; FUNCTION: [Angiotensin-converting enzyme, soluble form]: Soluble form that is released in blood plasma and other body fluids following proteolytic cleavage in the juxtamembrane stalk region. .; FUNCTION: [Isoform Testis-specific]: Isoform produced by alternative promoter usage that is specifically expressed in spermatocytes and adult testis, and which is required for male fertility . In contrast to somatic isoforms, only contains one catalytic domain . Acts as a dipeptidyl carboxypeptidase that removes dipeptides from the C-terminus of substrates . The identity of substrates that are needed for male fertility is unknown (By similarity). May also have a glycosidase activity which releases GPI-anchored proteins from the membrane by cleaving the mannose linkage in the GPI moiety. The GPIase activity was reported to be essential for the egg-binding ability of the sperm (By similarity). This activity is however unclear and has been challenged by other groups, suggesting that it may be indirect (By similarity). .

FUNCTION: Soluble form that is released in blood plasma and other body fluids following proteolytic cleavage in the juxtamembrane stalk region. .

FUNCTION: Soluble form that is released in blood plasma and other body fluids following proteolytic cleavage in the juxtamembrane stalk region. .

FUNCTION: Soluble form that is released in blood plasma and other body fluids following proteolytic cleavage in the juxtamembrane stalk region. .

FUNCTION: Soluble form that is released in blood plasma and other body fluids following proteolytic cleavage in the juxtamembrane stalk region. .

AccessionsENST00000578839.5
J3QSC7
Q1KSD9
A0A0A0MSN4
J3KTB8
ENST00000582627.1
ENST00000290863.10 [P12821-3]
J3KRH5
ENST00000582761.1
ENST00000290866.10 [P12821-1]
ENST00000579204.1
ENST00000579314.5
J3QLR4
I6L9B3
Q1KSG0
P12821
Q3KRI5
X4Y8J8
J3KSQ5
ENST00000582005.5
J3KTH9
Q3KRI4
ENST00000413513.7 [P12821-4]
I3UJJ7
ENST00000582678.5
J3KS28
ENST00000579726.5
ENST00000428043.5