ANGPT2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0001525Biological processangiogenesis
GO_0010812Biological processnegative regulation of cell-substrate adhesion
GO_0009749Biological processresponse to glucose
GO_0045766Biological processpositive regulation of angiogenesis
GO_0007165Biological processsignal transduction
GO_0014070Biological processresponse to organic cyclic compound
GO_0031100Biological processanimal organ regeneration
GO_0014823Biological processresponse to activity
GO_0071363Biological processcellular response to growth factor stimulus
GO_0043537Biological processnegative regulation of blood vessel endothelial cell migration
GO_0050928Biological processnegative regulation of positive chemotaxis
GO_0016525Biological processnegative regulation of angiogenesis
GO_0007281Biological processgerm cell development
GO_0048014Biological processTie signaling pathway
GO_0001666Biological processresponse to hypoxia
GO_0072012Biological processglomerulus vasculature development
GO_0010467Biological processgene expression
GO_0009612Biological processresponse to mechanical stimulus
GO_0060135Biological processmaternal process involved in female pregnancy
GO_0005615Cellular componentextracellular space
GO_0005576Cellular componentextracellular region
GO_0062023Cellular componentcollagen-containing extracellular matrix
GO_0042995Cellular componentcell projection
GO_0005102Molecular functionsignaling receptor binding
GO_0046872Molecular functionmetal ion binding
GO_0005515Molecular functionprotein binding
GO_0030971Molecular functionreceptor tyrosine kinase binding

IV. Literature review

[source]
Gene nameANGPT2
Protein nameAngiopoietin-2 (ANG-2)
Angiopoietin-2
Synonyms
DescriptionFUNCTION: Binds to TEK/TIE2, competing for the ANGPT1 binding site, and modulating ANGPT1 signaling . Can induce tyrosine phosphorylation of TEK/TIE2 in the absence of ANGPT1 . In the absence of angiogenic inducers, such as VEGF, ANGPT2-mediated loosening of cell-matrix contacts may induce endothelial cell apoptosis with consequent vascular regression. In concert with VEGF, it may facilitate endothelial cell migration and proliferation, thus serving as a permissive angiogenic signal . Involved in the regulation of lymphangiogenesis . .

AccessionsENST00000629816.3 [O15123-3]
ENST00000523120.2
O15123
E7EVQ3
ENST00000338312.10 [O15123-2]
ENST00000325203.9 [O15123-1]