I. Expression across cell types
Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| pericyte | 21 studies | 27% ± 8% | |
| smooth muscle cell | 5 studies | 28% ± 8% | |
| myofibroblast cell | 3 studies | 24% ± 11% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| pericyte | 21 studies | 27% ± 8% | |
| smooth muscle cell | 5 studies | 28% ± 8% | |
| myofibroblast cell | 3 studies | 24% ± 11% |
Insufficient scRNA-seq data for expression of KCNJ8 at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| breast | 100% | 2108.34 | 459 / 459 | 96% | 13.58 | 1075 / 1118 |
| pancreas | 100% | 2153.65 | 328 / 328 | 95% | 19.28 | 169 / 178 |
| liver | 100% | 2063.81 | 226 / 226 | 94% | 34.13 | 381 / 406 |
| lung | 99% | 1335.81 | 572 / 578 | 92% | 11.70 | 1058 / 1155 |
| adrenal gland | 100% | 1586.80 | 258 / 258 | 89% | 29.24 | 205 / 230 |
| prostate | 97% | 1341.06 | 238 / 245 | 89% | 9.65 | 449 / 502 |
| thymus | 100% | 1623.13 | 652 / 653 | 85% | 8.63 | 516 / 605 |
| kidney | 88% | 1001.53 | 78 / 89 | 86% | 19.57 | 778 / 901 |
| ovary | 99% | 1520.94 | 179 / 180 | 71% | 6.54 | 304 / 430 |
| bladder | 100% | 1457.67 | 21 / 21 | 64% | 5.67 | 321 / 504 |
| brain | 55% | 252.73 | 1463 / 2642 | 99% | 14.76 | 698 / 705 |
| stomach | 79% | 994.89 | 285 / 359 | 73% | 7.49 | 208 / 286 |
| intestine | 80% | 977.84 | 773 / 966 | 65% | 5.19 | 342 / 527 |
| uterus | 100% | 1753.27 | 170 / 170 | 45% | 6.93 | 206 / 459 |
| esophagus | 77% | 1398.26 | 1118 / 1445 | 66% | 5.03 | 121 / 183 |
| skin | 75% | 638.12 | 1354 / 1809 | 66% | 5.99 | 313 / 472 |
| adipose | 100% | 2642.90 | 1204 / 1204 | 0% | 0 | 0 / 0 |
| heart | 100% | 3118.75 | 861 / 861 | 0% | 0 | 0 / 0 |
| blood vessel | 99% | 1515.14 | 1325 / 1335 | 0% | 0 | 0 / 0 |
| muscle | 96% | 891.54 | 773 / 803 | 0% | 0 | 0 / 0 |
| spleen | 90% | 768.57 | 217 / 241 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 83% | 5.46 | 24 / 29 |
| tonsil | 0% | 0 | 0 / 0 | 64% | 4.54 | 29 / 45 |
| eye | 0% | 0 | 0 / 0 | 18% | 0.83 | 14 / 80 |
| peripheral blood | 0% | 1.51 | 2 / 929 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0030010 | Biological process | establishment of cell polarity |
| GO_0006813 | Biological process | potassium ion transport |
| GO_0002931 | Biological process | response to ischemia |
| GO_0001774 | Biological process | microglial cell activation |
| GO_0061535 | Biological process | glutamate secretion, neurotransmission |
| GO_0061762 | Biological process | CAMKK-AMPK signaling cascade |
| GO_0044546 | Biological process | NLRP3 inflammasome complex assembly |
| GO_0034976 | Biological process | response to endoplasmic reticulum stress |
| GO_0150104 | Biological process | transport across blood-brain barrier |
| GO_0008340 | Biological process | determination of adult lifespan |
| GO_0033198 | Biological process | response to ATP |
| GO_0034097 | Biological process | response to cytokine |
| GO_0150103 | Biological process | reactive gliosis |
| GO_0043330 | Biological process | response to exogenous dsRNA |
| GO_0008217 | Biological process | regulation of blood pressure |
| GO_0051607 | Biological process | defense response to virus |
| GO_0032868 | Biological process | response to insulin |
| GO_0001822 | Biological process | kidney development |
| GO_0098915 | Biological process | membrane repolarization during ventricular cardiac muscle cell action potential |
| GO_0002027 | Biological process | regulation of heart rate |
| GO_0060976 | Biological process | coronary vasculature development |
| GO_0032496 | Biological process | response to lipopolysaccharide |
| GO_0050905 | Biological process | neuromuscular process |
| GO_0098662 | Biological process | inorganic cation transmembrane transport |
| GO_0071805 | Biological process | potassium ion transmembrane transport |
| GO_0099505 | Biological process | regulation of presynaptic membrane potential |
| GO_0034765 | Biological process | regulation of monoatomic ion transmembrane transport |
| GO_0051124 | Biological process | synaptic assembly at neuromuscular junction |
| GO_0002250 | Biological process | adaptive immune response |
| GO_0015908 | Biological process | fatty acid transport |
| GO_1990573 | Biological process | potassium ion import across plasma membrane |
| GO_0001666 | Biological process | response to hypoxia |
| GO_0048144 | Biological process | fibroblast proliferation |
| GO_1904638 | Biological process | response to resveratrol |
| GO_0003229 | Biological process | ventricular cardiac muscle tissue development |
| GO_0006915 | Biological process | apoptotic process |
| GO_0060922 | Biological process | atrioventricular node cell differentiation |
| GO_0010467 | Biological process | gene expression |
| GO_0019226 | Biological process | transmission of nerve impulse |
| GO_0009410 | Biological process | response to xenobiotic stimulus |
| GO_0038066 | Biological process | p38MAPK cascade |
| GO_0042311 | Biological process | vasodilation |
| GO_0003007 | Biological process | heart morphogenesis |
| GO_0070588 | Biological process | calcium ion transmembrane transport |
| GO_0045444 | Biological process | fat cell differentiation |
| GO_0009306 | Biological process | protein secretion |
| GO_0031004 | Cellular component | potassium ion-transporting ATPase complex |
| GO_0098978 | Cellular component | glutamatergic synapse |
| GO_0008282 | Cellular component | inward rectifying potassium channel |
| GO_0005886 | Cellular component | plasma membrane |
| GO_0048787 | Cellular component | presynaptic active zone membrane |
| GO_0030016 | Cellular component | myofibril |
| GO_0042383 | Cellular component | sarcolemma |
| GO_0008076 | Cellular component | voltage-gated potassium channel complex |
| GO_0019829 | Molecular function | ATPase-coupled monoatomic cation transmembrane transporter activity |
| GO_1902282 | Molecular function | voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization |
| GO_0017098 | Molecular function | sulfonylurea receptor binding |
| GO_0099508 | Molecular function | voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential |
| GO_0005242 | Molecular function | inward rectifier potassium channel activity |
| GO_0005524 | Molecular function | ATP binding |
| GO_0005515 | Molecular function | protein binding |
| GO_0015272 | Molecular function | ATP-activated inward rectifier potassium channel activity |
| Gene name | KCNJ8 |
| Protein name | Potassium inwardly rectifying channel subfamily J member 8 ATP-sensitive inward rectifier potassium channel 8 (Inward rectifier K(+) channel Kir6.1) (Potassium channel, inwardly rectifying subfamily J member 8) (uKATP-1) |
| Synonyms | |
| Description | FUNCTION: This potassium channel is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by external barium (By similarity). . |
| Accessions | ENST00000665145.1 ENST00000240662.3 Q15842 F5GY12 ENST00000667884.1 ENST00000537950.1 |
