NOS2 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of NOS2 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of NOS2 at tissue level.

III. Associated gene sets

GO_0051712Biological processpositive regulation of killing of cells of another organism
GO_0045454Biological processcell redox homeostasis
GO_0042177Biological processnegative regulation of protein catabolic process
GO_0050796Biological processregulation of insulin secretion
GO_0032310Biological processprostaglandin secretion
GO_0071466Biological processcellular response to xenobiotic stimulus
GO_0006954Biological processinflammatory response
GO_0010629Biological processnegative regulation of gene expression
GO_0043457Biological processregulation of cellular respiration
GO_0009617Biological processresponse to bacterium
GO_0050829Biological processdefense response to Gram-negative bacterium
GO_0007623Biological processcircadian rhythm
GO_0006527Biological processarginine catabolic process
GO_0009725Biological processresponse to hormone
GO_0045776Biological processnegative regulation of blood pressure
GO_1900015Biological processregulation of cytokine production involved in inflammatory response
GO_0001666Biological processresponse to hypoxia
GO_0006809Biological processnitric oxide biosynthetic process
GO_0031284Biological processpositive regulation of guanylate cyclase activity
GO_0007263Biological processnitric oxide mediated signal transduction
GO_0018119Biological processpeptidyl-cysteine S-nitrosylation
GO_0032757Biological processpositive regulation of interleukin-8 production
GO_0042742Biological processdefense response to bacterium
GO_0071222Biological processcellular response to lipopolysaccharide
GO_0002227Biological processinnate immune response in mucosa
GO_0006801Biological processsuperoxide metabolic process
GO_0001912Biological processpositive regulation of leukocyte mediated cytotoxicity
GO_0042127Biological processregulation of cell population proliferation
GO_0032496Biological processresponse to lipopolysaccharide
GO_0032755Biological processpositive regulation of interleukin-6 production
GO_0071346Biological processcellular response to type II interferon
GO_0005886Cellular componentplasma membrane
GO_0048471Cellular componentperinuclear region of cytoplasm
GO_0005654Cellular componentnucleoplasm
GO_0005777Cellular componentperoxisome
GO_0030863Cellular componentcortical cytoskeleton
GO_0005829Cellular componentcytosol
GO_0005782Cellular componentperoxisomal matrix
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0042803Molecular functionprotein homodimerization activity
GO_0010181Molecular functionFMN binding
GO_0050660Molecular functionflavin adenine dinucleotide binding
GO_0004517Molecular functionnitric-oxide synthase activity
GO_0034617Molecular functiontetrahydrobiopterin binding
GO_0034618Molecular functionarginine binding
GO_0050661Molecular functionNADP binding
GO_0020037Molecular functionheme binding
GO_0046872Molecular functionmetal ion binding
GO_0005516Molecular functioncalmodulin binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameNOS2
Protein nameNitric oxide synthase 2
Nitric oxide synthase, inducible (EC 1.14.13.39) (Hepatocyte NOS) (HEP-NOS) (Inducible NO synthase) (Inducible NOS) (iNOS) (NOS type II) (Peptidyl-cysteine S-nitrosylase NOS2)
Nitric oxide synthase (EC 1.14.13.39)
nitric-oxide synthase (NADPH) (EC 1.14.13.39)
SynonymsNOS2A
DescriptionFUNCTION: Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body . In macrophages, NO mediates tumoricidal and bactericidal actions. Also has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such PTGS2/COX2 (By similarity). As component of the iNOS-S100A8/9 transnitrosylase complex involved in the selective inflammatory stimulus-dependent S-nitrosylation of GAPDH on 'Cys-247' implicated in regulation of the GAIT complex activity and probably multiple targets including ANXA5, EZR, MSN and VIM . Involved in inflammation, enhances the synthesis of pro-inflammatory mediators such as IL6 and IL8 . .

FUNCTION: Produces nitric oxide (NO) which is a messenger molecule with diverse functions. .

AccessionsA0A8V8TKX9
A0A8V8TMI7
ENST00000697339.1
ENST00000313735.11 [P35228-1]
ENST00000697338.1
A0A2R8YDS4
P35228
A0A8V8TLB1
ENST00000697337.1
A0A8V8TKZ7
ENST00000646938.1
ENST00000697340.1