APAF1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0007584Biological processresponse to nutrient
GO_0008635Biological processactivation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c
GO_0070059Biological processintrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
GO_0006919Biological processactivation of cysteine-type endopeptidase activity involved in apoptotic process
GO_0071560Biological processcellular response to transforming growth factor beta stimulus
GO_0030900Biological processforebrain development
GO_0001822Biological processkidney development
GO_0072432Biological processresponse to G1 DNA damage checkpoint signaling
GO_0051402Biological processneuron apoptotic process
GO_0097193Biological processintrinsic apoptotic signaling pathway
GO_0042981Biological processregulation of apoptotic process
GO_0030154Biological processcell differentiation
GO_0001666Biological processresponse to hypoxia
GO_0010659Biological processcardiac muscle cell apoptotic process
GO_0001843Biological processneural tube closure
GO_0006915Biological processapoptotic process
GO_2001235Biological processpositive regulation of apoptotic signaling pathway
GO_0043065Biological processpositive regulation of apoptotic process
GO_0007399Biological processnervous system development
GO_1902510Biological processregulation of apoptotic DNA fragmentation
GO_0005576Cellular componentextracellular region
GO_0070062Cellular componentextracellular exosome
GO_0032991Cellular componentprotein-containing complex
GO_0043293Cellular componentapoptosome
GO_0034774Cellular componentsecretory granule lumen
GO_1904813Cellular componentficolin-1-rich granule lumen
GO_0005829Cellular componentcytosol
GO_0005634Cellular componentnucleus
GO_0043531Molecular functionADP binding
GO_0008656Molecular functioncysteine-type endopeptidase activator activity involved in apoptotic process
GO_0031072Molecular functionheat shock protein binding
GO_0042802Molecular functionidentical protein binding
GO_0000166Molecular functionnucleotide binding
GO_0005524Molecular functionATP binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameAPAF1
Protein nameAlternative protein APAF1
Apoptotic protease-activating factor 1 (APAF-1)
Apoptotic peptidase activating factor 1
SynonymsKIAA0413
DescriptionFUNCTION: Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. Isoform 6 is less effective in inducing apoptosis. .

FUNCTION: Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. .

FUNCTION: Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. .

AccessionsENST00000547045.5 [O14727-4]
O14727
ENST00000550527.5 [O14727-2]
A5YM44
C9JLV4
ENST00000549007.1
ENST00000547743.1
ENST00000552268.5 [O14727-6]
A7E2A2
ENST00000357310.5 [O14727-4]
ENST00000333991.5 [O14727-6]
ENST00000359972.6 [O14727-3]
ENST00000551964.6 [O14727-1]
L8E801
F8VNZ0