LOXL2 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of LOXL2 at tissue level.

III. Associated gene sets

GO_1902455Biological processnegative regulation of stem cell population maintenance
GO_0001837Biological processepithelial to mesenchymal transition
GO_0018057Biological processpeptidyl-lysine oxidation
GO_0032332Biological processpositive regulation of chondrocyte differentiation
GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_0002040Biological processsprouting angiogenesis
GO_0070828Biological processheterochromatin organization
GO_0036211Biological processprotein modification process
GO_0043542Biological processendothelial cell migration
GO_0001666Biological processresponse to hypoxia
GO_0001935Biological processendothelial cell proliferation
GO_0010718Biological processpositive regulation of epithelial to mesenchymal transition
GO_0046688Biological processresponse to copper ion
GO_0030199Biological processcollagen fibril organization
GO_0045892Biological processnegative regulation of DNA-templated transcription
GO_0005615Cellular componentextracellular space
GO_0016020Cellular componentmembrane
GO_0005654Cellular componentnucleoplasm
GO_0062023Cellular componentcollagen-containing extracellular matrix
GO_0005783Cellular componentendoplasmic reticulum
GO_0005604Cellular componentbasement membrane
GO_0000785Cellular componentchromatin
GO_0005634Cellular componentnucleus
GO_0004720Molecular functionprotein-lysine 6-oxidase activity
GO_0070492Molecular functionoligosaccharide binding
GO_0005507Molecular functioncopper ion binding
GO_0005509Molecular functioncalcium ion binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameLOXL2
Protein nameLysyl oxidase homolog 2 (EC 1.4.3.13) (Lysyl oxidase-like protein 2) (Lysyl oxidase-related protein 2) (Lysyl oxidase-related protein WS9-14)
Lysyl oxidase homolog 2 (Lysyl oxidase-like protein 2)
Lysyl oxidase like 2
Lysyl oxidase homolog (EC 1.4.3.13)
Synonyms
DescriptionFUNCTION: Mediates the post-translational oxidative deamination of lysine residues on target proteins leading to the formation of deaminated lysine (allysine) . Acts as a transcription corepressor and specifically mediates deamination of trimethylated 'Lys-4' of histone H3 (H3K4me3), a specific tag for epigenetic transcriptional activation . Shows no activity against histone H3 when it is trimethylated on 'Lys-9' (H3K9me3) or 'Lys-27' (H3K27me3) or when 'Lys-4' is monomethylated (H3K4me1) or dimethylated (H3K4me2) . Also mediates deamination of methylated TAF10, a member of the transcription factor IID (TFIID) complex, which induces release of TAF10 from promoters, leading to inhibition of TFIID-dependent transcription . LOXL2-mediated deamination of TAF10 results in transcriptional repression of genes required for embryonic stem cell pluripotency including POU5F1/OCT4, NANOG, KLF4 and SOX2 (By similarity). Involved in epithelial to mesenchymal transition (EMT) via interaction with SNAI1 and participates in repression of E-cadherin CDH1, probably by mediating deamination of histone H3 . During EMT, involved with SNAI1 in negatively regulating pericentromeric heterochromatin transcription . SNAI1 recruits LOXL2 to pericentromeric regions to oxidize histone H3 and repress transcription which leads to release of heterochromatin component CBX5/HP1A, enabling chromatin reorganization and acquisition of mesenchymal traits . Interacts with the endoplasmic reticulum protein HSPA5 which activates the IRE1-XBP1 pathway of the unfolded protein response, leading to expression of several transcription factors involved in EMT and subsequent EMT induction . Involved in E-cadherin repression following hypoxia, a hallmark of EMT believed to amplify tumor aggressiveness, suggesting that it may play a role in tumor progression . When secreted into the extracellular matrix, promotes cross-linking of extracellular matrix proteins by mediating oxidative deamination of peptidyl lysine residues in precursors to fibrous collagen and elastin . Acts as a regulator of sprouting angiogenesis, probably via collagen IV scaffolding . Acts as a regulator of chondrocyte differentiation, probably by regulating expression of factors that control chondrocyte differentiation (By similarity). .

FUNCTION: Mediates the post-translational oxidative deamination of lysine residues on target proteins leading to the formation of deaminated lysine (allysine). .

FUNCTION: Mediates the post-translational oxidative deamination of lysine residues on target proteins leading to the formation of deaminated lysine (allysine). .

AccessionsE5RHH3
ENST00000519243.1
ENST00000523833.2
E5RFE2
E5RJL2
ENST00000518878.5
R4GMS2
Q9Y4K0
ENST00000520871.1
ENST00000524168.1
H0YAP6
ENST00000518083.5
ENST00000520349.1
E5RFY0
W6I206
E5RI22
H0YAR1
ENST00000389131.8
ENST00000524144.5
W8QRJ0