WDR83 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of WDR83 at tissue level.

III. Associated gene sets

GO_0000398Biological processmRNA splicing, via spliceosome
GO_0090594Biological processinflammatory response to wounding
GO_0043122Biological processregulation of canonical NF-kappaB signal transduction
GO_0000375Biological processRNA splicing, via transesterification reactions
GO_0001666Biological processresponse to hypoxia
GO_0032496Biological processresponse to lipopolysaccharide
GO_0010008Cellular componentendosome membrane
GO_0005764Cellular componentlysosome
GO_0071013Cellular componentcatalytic step 2 spliceosome
GO_0005681Cellular componentspliceosomal complex
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameWDR83
Protein nameWD repeat domain-containing protein 83 (Mitogen-activated protein kinase organizer 1) (MAPK organizer 1)
WD repeat domain-containing protein 83 (Mitogen-activated protein kinase organizer 1)
SynonymsMORG1
hCG_172499
DescriptionFUNCTION: Molecular scaffold protein for various multimeric protein complexes. Acts as a module in the assembly of a multicomponent scaffold for the ERK pathway, linking ERK responses to specific agonists. At low concentrations it enhances ERK activation, whereas high concentrations lead to the inhibition of ERK activation. Also involved in response to hypoxia by acting as a negative regulator of HIF1A/HIF-1-alpha via its interaction with EGLN3/PHD3. May promote degradation of HIF1A. May act by recruiting signaling complexes to a specific upstream activator (By similarity). May also be involved in pre-mRNA splicing. .

AccessionsENST00000418543.8
Q9BRX9
F8VSE4
ENST00000547481.5
H7C0S9
G3V221
ENST00000553179.5
ENST00000548381.5
H0YIE8
ENST00000547797.1
ENST00000425834.7