Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| endothelial cell | 21 studies | 27% ± 9% | |
| capillary endothelial cell | 9 studies | 24% ± 3% | |
| adipocyte | 9 studies | 49% ± 12% | |
| vein endothelial cell | 6 studies | 20% ± 4% | |
| endothelial cell of artery | 4 studies | 18% ± 3% | |
| pericyte | 4 studies | 34% ± 17% | |
| glomerular endothelial cell | 3 studies | 35% ± 2% | |
| endothelial cell of vascular tree | 3 studies | 29% ± 13% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| adipose | 3 studies | 23% ± 9% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| kidney | 99% | 5313.38 | 88 / 89 | 99% | 68.78 | 892 / 901 |
| prostate | 97% | 3668.31 | 238 / 245 | 100% | 42.48 | 501 / 502 |
| thymus | 100% | 6432.60 | 651 / 653 | 95% | 19.75 | 575 / 605 |
| breast | 99% | 18102.71 | 454 / 459 | 95% | 21.89 | 1058 / 1118 |
| ovary | 99% | 4091.92 | 179 / 180 | 94% | 20.86 | 404 / 430 |
| adrenal gland | 97% | 2892.71 | 251 / 258 | 90% | 17.36 | 207 / 230 |
| lung | 100% | 11046.96 | 577 / 578 | 75% | 9.54 | 862 / 1155 |
| pancreas | 82% | 1559.23 | 268 / 328 | 91% | 13.50 | 162 / 178 |
| liver | 85% | 2044.12 | 191 / 226 | 87% | 12.40 | 355 / 406 |
| stomach | 99% | 3652.38 | 357 / 359 | 70% | 8.25 | 200 / 286 |
| bladder | 100% | 3439.67 | 21 / 21 | 62% | 7.39 | 310 / 504 |
| intestine | 94% | 3994.11 | 911 / 966 | 57% | 5.46 | 300 / 527 |
| uterus | 99% | 4599.64 | 168 / 170 | 52% | 9.16 | 240 / 459 |
| esophagus | 81% | 3616.94 | 1172 / 1445 | 61% | 7.05 | 112 / 183 |
| skin | 60% | 1682.74 | 1094 / 1809 | 67% | 8.29 | 315 / 472 |
| brain | 30% | 486.54 | 782 / 2642 | 87% | 8.32 | 614 / 705 |
| adipose | 100% | 24327.33 | 1204 / 1204 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 100% | 12.98 | 1 / 1 |
| blood vessel | 100% | 6459.78 | 1332 / 1335 | 0% | 0 | 0 / 0 |
| spleen | 100% | 4877.11 | 240 / 241 | 0% | 0 | 0 / 0 |
| heart | 99% | 4709.02 | 856 / 861 | 0% | 0 | 0 / 0 |
| muscle | 99% | 5761.70 | 794 / 803 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 31% | 2.11 | 25 / 80 |
| tonsil | 0% | 0 | 0 / 0 | 27% | 1.94 | 12 / 45 |
| lymph node | 0% | 0 | 0 / 0 | 17% | 1.23 | 5 / 29 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| peripheral blood | 0% | 0 | 0 / 929 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_0071300 | Biological process | cellular response to retinoic acid |
| GO_0019221 | Biological process | cytokine-mediated signaling pathway |
| GO_0007605 | Biological process | sensory perception of sound |
| GO_0001525 | Biological process | angiogenesis |
| GO_0060856 | Biological process | establishment of blood-brain barrier |
| GO_0042701 | Biological process | progesterone secretion |
| GO_0008283 | Biological process | cell population proliferation |
| GO_0051091 | Biological process | positive regulation of DNA-binding transcription factor activity |
| GO_0045446 | Biological process | endothelial cell differentiation |
| GO_0061299 | Biological process | retina vasculature morphogenesis in camera-type eye |
| GO_0007223 | Biological process | Wnt signaling pathway, calcium modulating pathway |
| GO_0061304 | Biological process | retinal blood vessel morphogenesis |
| GO_1990830 | Biological process | cellular response to leukemia inhibitory factor |
| GO_0001570 | Biological process | vasculogenesis |
| GO_0110135 | Biological process | Norrin signaling pathway |
| GO_0060070 | Biological process | canonical Wnt signaling pathway |
| GO_0061301 | Biological process | cerebellum vasculature morphogenesis |
| GO_0030947 | Biological process | regulation of vascular endothelial growth factor receptor signaling pathway |
| GO_0030182 | Biological process | neuron differentiation |
| GO_0007186 | Biological process | G protein-coupled receptor signaling pathway |
| GO_0150012 | Biological process | positive regulation of neuron projection arborization |
| GO_0034446 | Biological process | substrate adhesion-dependent cell spreading |
| GO_0045893 | Biological process | positive regulation of DNA-templated transcription |
| GO_0030335 | Biological process | positive regulation of cell migration |
| GO_0050775 | Biological process | positive regulation of dendrite morphogenesis |
| GO_0001666 | Biological process | response to hypoxia |
| GO_0031987 | Biological process | locomotion involved in locomotory behavior |
| GO_0035567 | Biological process | non-canonical Wnt signaling pathway |
| GO_0016055 | Biological process | Wnt signaling pathway |
| GO_0035426 | Biological process | extracellular matrix-cell signaling |
| GO_0010812 | Biological process | negative regulation of cell-substrate adhesion |
| GO_0098978 | Cellular component | glutamatergic synapse |
| GO_0005886 | Cellular component | plasma membrane |
| GO_0030669 | Cellular component | clathrin-coated endocytic vesicle membrane |
| GO_0030425 | Cellular component | dendrite |
| GO_0005911 | Cellular component | cell-cell junction |
| GO_0009986 | Cellular component | cell surface |
| GO_0017147 | Molecular function | Wnt-protein binding |
| GO_0042803 | Molecular function | protein homodimerization activity |
| GO_0038023 | Molecular function | signaling receptor activity |
| GO_0004930 | Molecular function | G protein-coupled receptor activity |
| GO_0044877 | Molecular function | protein-containing complex binding |
| GO_0019955 | Molecular function | cytokine binding |
| GO_0001540 | Molecular function | amyloid-beta binding |
| GO_0031625 | Molecular function | ubiquitin protein ligase binding |
| GO_0042813 | Molecular function | Wnt receptor activity |
| GO_0030165 | Molecular function | PDZ domain binding |
| GO_0004896 | Molecular function | cytokine receptor activity |
| GO_0046982 | Molecular function | protein heterodimerization activity |
| GO_0005515 | Molecular function | protein binding |
| Gene name | FZD4 |
| Protein name | Soluble-type polypeptide FZD4S Frizzled-4 (Fz-4) (hFz4) (FzE4) (CD antigen CD344) |
| Synonyms | |
| Description | FUNCTION: Receptor for Wnt proteins . Most frizzled receptors are coupled to the beta-catenin (CTNNB1) canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin (CTNNB1) and activation of Wnt target genes . Plays a critical role in retinal vascularization by acting as a receptor for Wnt proteins and norrin (NDP) (By similarity). In retina, it can be activated by Wnt protein-binding and also by Wnt-independent signaling via binding of norrin (NDP), promoting in both cases beta-catenin (CTNNB1) accumulation and stimulation of LEF/TCF-mediated transcriptional programs (By similarity). A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. . |
| Accessions | ENST00000531380.2 Q9ULV1 Q9BY80 |
