CYGB report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of CYGB at tissue level.

III. Associated gene sets

GO_0046210Biological processnitric oxide catabolic process
GO_0019395Biological processfatty acid oxidation
GO_0032966Biological processnegative regulation of collagen biosynthetic process
GO_0010764Biological processnegative regulation of fibroblast migration
GO_2000490Biological processnegative regulation of hepatic stellate cell activation
GO_0001666Biological processresponse to hypoxia
GO_0015671Biological processoxygen transport
GO_0019430Biological processremoval of superoxide radicals
GO_0006979Biological processresponse to oxidative stress
GO_0043025Cellular componentneuronal cell body
GO_0043005Cellular componentneuron projection
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0004601Molecular functionperoxidase activity
GO_0004096Molecular functioncatalase activity
GO_0141118Molecular functionnitric oxide dioxygenase activity, heme protein as donor
GO_0070025Molecular functioncarbon monoxide binding
GO_0004784Molecular functionsuperoxide dismutase activity
GO_0019825Molecular functionoxygen binding
GO_0016491Molecular functionoxidoreductase activity
GO_0005506Molecular functioniron ion binding
GO_0020037Molecular functionheme binding
GO_0005344Molecular functionoxygen carrier activity
GO_0047888Molecular functionfatty acid peroxidase activity
GO_0098809Molecular functionnitrite reductase activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameCYGB
Protein nameCytoglobin
Cytoglobin (Histoglobin) (HGb) (Nitric oxygen dioxygenase CYGB) (NOD) (EC 1.14.12.-) (Nitrite reductase CYGB) (EC 1.7.-.-) (Pseudoperoxidase CYGB) (EC 1.11.1.-) (Stellate cell activation-associated protein) (Superoxide dismutase CYGB) (EC 1.15.1.1)
SynonymsSTAP
DescriptionFUNCTION: Probable multifunctional globin with a hexacoordinated heme iron required for the catalysis of various reactions depending on redox condition of the cell as well as oxygen availability . Has a nitric oxide dioxygenase (NOD) activity and is most probably involved in cell-mediated and oxygen-dependent nitric oxide consumption . By scavenging this second messenger may regulate several biological processes including endothelium-mediated vasodilation and vascular tone . Under normoxic conditions functions as a nitric oxide dioxygenase (NOD) but under hypoxic conditions the globin may switch its function to that of a nitrite (NO2) reductase (NiR), generating nitric oxide . Could also have peroxidase and superoxide dismutase activities, detoxifying reactive oxygen species and protecting cells against oxidative stress . Also binds dioxygen with low affinity and could function as an oxygen sensor but has probably no function as a respiratory oxygen carrier . .

AccessionsK7EIM9
ENST00000590175.5
Q8WWM9
ENST00000589145.1
K7EMC7
ENST00000589342.1
ENST00000293230.10