I. Expression across cell types
Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| hepatocyte | 4 studies | 32% ± 21% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| hepatocyte | 4 studies | 32% ± 21% |
Insufficient scRNA-seq data for expression of F7 at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| liver | 100% | 9922.67 | 226 / 226 | 97% | 110.43 | 392 / 406 |
| breast | 76% | 38.20 | 349 / 459 | 68% | 8.24 | 765 / 1118 |
| brain | 92% | 89.59 | 2423 / 2642 | 30% | 0.61 | 215 / 705 |
| kidney | 96% | 51.35 | 85 / 89 | 14% | 0.44 | 123 / 901 |
| ovary | 95% | 58.97 | 171 / 180 | 6% | 0.15 | 27 / 430 |
| eye | 0% | 0 | 0 / 0 | 100% | 17.61 | 80 / 80 |
| prostate | 94% | 59.95 | 230 / 245 | 5% | 0.08 | 23 / 502 |
| stomach | 61% | 14.89 | 218 / 359 | 35% | 1.95 | 100 / 286 |
| skin | 74% | 35.40 | 1333 / 1809 | 11% | 0.41 | 50 / 472 |
| intestine | 50% | 19.16 | 485 / 966 | 28% | 1.59 | 148 / 527 |
| thymus | 60% | 13.47 | 392 / 653 | 15% | 0.40 | 93 / 605 |
| adipose | 75% | 29.48 | 897 / 1204 | 0% | 0 | 0 / 0 |
| esophagus | 59% | 17.52 | 858 / 1445 | 14% | 0.47 | 25 / 183 |
| bladder | 57% | 12.38 | 12 / 21 | 12% | 0.70 | 58 / 504 |
| uterus | 56% | 32.01 | 96 / 170 | 12% | 0.79 | 55 / 459 |
| lung | 53% | 12.11 | 304 / 578 | 12% | 0.74 | 144 / 1155 |
| heart | 54% | 15.37 | 463 / 861 | 0% | 0 | 0 / 0 |
| pancreas | 32% | 6.09 | 104 / 328 | 12% | 1.04 | 22 / 178 |
| adrenal gland | 14% | 2.80 | 37 / 258 | 14% | 0.25 | 32 / 230 |
| blood vessel | 27% | 6.35 | 357 / 1335 | 0% | 0 | 0 / 0 |
| spleen | 16% | 18.07 | 39 / 241 | 0% | 0 | 0 / 0 |
| peripheral blood | 13% | 3.79 | 117 / 929 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 11% | 0.66 | 5 / 45 |
| muscle | 5% | 0.93 | 41 / 803 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 29 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0070723 | Biological process | response to cholesterol |
| GO_0032355 | Biological process | response to estradiol |
| GO_1905217 | Biological process | response to astaxanthin |
| GO_0010641 | Biological process | positive regulation of platelet-derived growth factor receptor signaling pathway |
| GO_0043627 | Biological process | response to estrogen |
| GO_1905225 | Biological process | response to thyrotropin-releasing hormone |
| GO_0016485 | Biological process | protein processing |
| GO_0031100 | Biological process | animal organ regeneration |
| GO_0007596 | Biological process | blood coagulation |
| GO_0007623 | Biological process | circadian rhythm |
| GO_0010037 | Biological process | response to carbon dioxide |
| GO_0060416 | Biological process | response to growth hormone |
| GO_0033595 | Biological process | response to genistein |
| GO_0030335 | Biological process | positive regulation of cell migration |
| GO_0001666 | Biological process | response to hypoxia |
| GO_0032571 | Biological process | response to vitamin K |
| GO_0030194 | Biological process | positive regulation of blood coagulation |
| GO_0050927 | Biological process | positive regulation of positive chemotaxis |
| GO_0097068 | Biological process | response to thyroxine |
| GO_0032008 | Biological process | positive regulation of TOR signaling |
| GO_0002690 | Biological process | positive regulation of leukocyte chemotaxis |
| GO_1904612 | Biological process | response to 2,3,7,8-tetrachlorodibenzodioxine |
| GO_1904400 | Biological process | response to Thyroid stimulating hormone |
| GO_0005615 | Cellular component | extracellular space |
| GO_0005576 | Cellular component | extracellular region |
| GO_0031982 | Cellular component | vesicle |
| GO_0005886 | Cellular component | plasma membrane |
| GO_0005796 | Cellular component | Golgi lumen |
| GO_1905286 | Cellular component | serine-type peptidase complex |
| GO_0062023 | Cellular component | collagen-containing extracellular matrix |
| GO_0005788 | Cellular component | endoplasmic reticulum lumen |
| GO_0005102 | Molecular function | signaling receptor binding |
| GO_0008236 | Molecular function | serine-type peptidase activity |
| GO_0005509 | Molecular function | calcium ion binding |
| GO_0005515 | Molecular function | protein binding |
| GO_0004252 | Molecular function | serine-type endopeptidase activity |
| Gene name | F7 |
| Protein name | Coagulation factor VII (EC 3.4.21.21) (Proconvertin) (Serum prothrombin conversion accelerator) (SPCA) (Eptacog alfa) [Cleaved into: Factor VII light chain; Factor VII heavy chain] Coagulation factor VII Alternative protein F7 |
| Synonyms | |
| Description | FUNCTION: Initiates the extrinsic pathway of blood coagulation. Serine protease that circulates in the blood in a zymogen form. Factor VII is converted to factor VIIa by factor Xa, factor XIIa, factor IXa, or thrombin by minor proteolysis. In the presence of tissue factor and calcium ions, factor VIIa then converts factor X to factor Xa by limited proteolysis. Factor VIIa will also convert factor IX to factor IXa in the presence of tissue factor and calcium. |
| Accessions | A3RMR0 ENST00000346342.8 [P08709-2] E9PH36 F5H8B0 ENST00000541084.5 L8EC53 A3RMR1 ENST00000444337.1 P08709 ENST00000375581.3 [P08709-1] |
