AJUBA report

I. Expression across cell types

Insufficient scRNA-seq data for expression of AJUBA at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of AJUBA at tissue level.

III. Associated gene sets

GO_0046474Biological processglycerophospholipid biosynthetic process
GO_0035278Biological processmiRNA-mediated gene silencing by inhibition of translation
GO_0030032Biological processlamellipodium assembly
GO_0031328Biological processpositive regulation of cellular biosynthetic process
GO_0007010Biological processcytoskeleton organization
GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_0031334Biological processpositive regulation of protein-containing complex assembly
GO_0035331Biological processnegative regulation of hippo signaling
GO_0035195Biological processmiRNA-mediated post-transcriptional gene silencing
GO_0043123Biological processpositive regulation of canonical NF-kappaB signal transduction
GO_0030334Biological processregulation of cell migration
GO_0001666Biological processresponse to hypoxia
GO_0006355Biological processregulation of DNA-templated transcription
GO_0016339Biological processcalcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules
GO_0048041Biological processfocal adhesion assembly
GO_0008104Biological processprotein localization
GO_0035313Biological processwound healing, spreading of epidermal cells
GO_1900037Biological processregulation of cellular response to hypoxia
GO_0005886Cellular componentplasma membrane
GO_0005813Cellular componentcentrosome
GO_0005654Cellular componentnucleoplasm
GO_0005794Cellular componentGolgi apparatus
GO_0005925Cellular componentfocal adhesion
GO_0000932Cellular componentP-body
GO_0005911Cellular componentcell-cell junction
GO_0005829Cellular componentcytosol
GO_0005912Cellular componentadherens junction
GO_0030027Cellular componentlamellipodium
GO_0005667Cellular componenttranscription regulator complex
GO_0005634Cellular componentnucleus
GO_0045294Molecular functionalpha-catenin binding
GO_0003682Molecular functionchromatin binding
GO_0051015Molecular functionactin filament binding
GO_0003714Molecular functiontranscription corepressor activity
GO_0030295Molecular functionprotein kinase activator activity
GO_0046872Molecular functionmetal ion binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameAJUBA
Protein nameLIM domain-containing protein ajuba
Ajuba LIM protein
SynonymsJUB
DescriptionFUNCTION: Adapter or scaffold protein which participates in the assembly of numerous protein complexes and is involved in several cellular processes such as cell fate determination, cytoskeletal organization, repression of gene transcription, mitosis, cell-cell adhesion, cell differentiation, proliferation and migration. Contributes to the linking and/or strengthening of epithelia cell-cell junctions in part by linking adhesive receptors to the actin cytoskeleton. May be involved in signal transduction from cell adhesion sites to the nucleus. Plays an important role in regulation of the kinase activity of AURKA for mitotic commitment. Also a component of the IL-1 signaling pathway modulating IL-1-induced NFKB1 activation by influencing the assembly and activity of the PRKCZ-SQSTM1-TRAF6 multiprotein signaling complex. Functions as an HDAC-dependent corepressor for a subset of GFI1 target genes. Acts as a transcriptional corepressor for SNAI1 and SNAI2/SLUG-dependent repression of E-cadherin transcription. Acts as a hypoxic regulator by bridging an association between the prolyl hydroxylases and VHL enabling efficient degradation of HIF1A. Positively regulates microRNA (miRNA)-mediated gene silencing. Negatively regulates the Hippo signaling pathway and antagonizes phosphorylation of YAP1. .

AccessionsENST00000553592.5
Q96IF1
ENST00000262713.7 [Q96IF1-1]
ENST00000397388.7 [Q96IF1-2]
ENST00000556731.5
ENST00000553736.1
ENST00000553911.1
G3V481
H0YJL9
G3V5F5