UCP3 | OmnibusX

sc-RNAseq data

Insufficient scRNA-seq data for expression of UCP3 at tissue level.

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
brain	96%	199.24	2530 / 2642	89%	2.02	624 / 705
thymus	100%	317.61	653 / 653	76%	1.73	460 / 605
uterus	98%	169.02	167 / 170	71%	1.50	328 / 459
breast	99%	149.64	454 / 459	65%	1.32	728 / 1118
ovary	94%	120.33	170 / 180	63%	1.31	273 / 430
prostate	100%	220.34	244 / 245	50%	0.82	249 / 502
lung	97%	164.13	559 / 578	51%	0.95	586 / 1155
bladder	100%	167.57	21 / 21	45%	0.93	226 / 504
esophagus	94%	150.93	1359 / 1445	49%	0.89	89 / 183
kidney	99%	145.16	88 / 89	43%	0.75	389 / 901
adrenal gland	100%	181.46	257 / 258	40%	0.65	92 / 230
skin	93%	119.93	1681 / 1809	35%	0.63	165 / 472
pancreas	74%	62.86	244 / 328	47%	0.76	83 / 178
intestine	100%	178.13	962 / 966	19%	0.26	98 / 527
stomach	91%	109.57	328 / 359	20%	0.28	58 / 286
muscle	100%	20428.17	803 / 803	0%	0	0 / 0
spleen	100%	349.28	241 / 241	0%	0	0 / 0
ureter	0%	0	0 / 0	100%	2.32	1 / 1
adipose	98%	133.82	1180 / 1204	0%	0	0 / 0
heart	96%	132.31	828 / 861	0%	0	0 / 0
blood vessel	95%	121.84	1265 / 1335	0%	0	0 / 0
liver	78%	67.85	177 / 226	12%	0.19	47 / 406
peripheral blood	80%	93.98	739 / 929	0%	0	0 / 0
lymph node	0%	0	0 / 0	66%	1.35	19 / 29
tonsil	0%	0	0 / 0	51%	1.11	23 / 45
eye	0%	0	0 / 0	19%	0.25	15 / 80
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

GO_0007584	Biological process	response to nutrient
GO_1990542	Biological process	mitochondrial transmembrane transport
GO_0000303	Biological process	response to superoxide
GO_1901557	Biological process	response to fenofibrate
GO_0032868	Biological process	response to insulin
GO_0032870	Biological process	cellular response to hormone stimulus
GO_0014823	Biological process	response to activity
GO_0006631	Biological process	fatty acid metabolic process
GO_1990845	Biological process	adaptive thermogenesis
GO_0051384	Biological process	response to glucocorticoid
GO_0009409	Biological process	response to cold
GO_0001666	Biological process	response to hypoxia
GO_1901373	Biological process	lipid hydroperoxide transport
GO_0006629	Biological process	lipid metabolic process
GO_1902600	Biological process	proton transmembrane transport
GO_0007585	Biological process	respiratory gaseous exchange by respiratory system
GO_0005739	Cellular component	mitochondrion
GO_0005743	Cellular component	mitochondrial inner membrane
GO_0015078	Molecular function	proton transmembrane transporter activity
GO_0015085	Molecular function	calcium ion transmembrane transporter activity
GO_0017077	Molecular function	oxidative phosphorylation uncoupler activity
GO_0005515	Molecular function	protein binding

Gene name	UCP3
Protein name	Putative mitochondrial transporter UCP3 (Solute carrier family 25 member 9) (Uncoupling protein-3) (UCP 3) Putative mitochondrial transporter UCP3 (Solute carrier family 25 member 9)
Synonyms	SLC25A9 hCG_1818188
Description	FUNCTION: Putative transmembrane transporter that plays a role in mitochondrial metabolism via an as yet unclear mechanism . Originally, this mitochondrial protein was thought to act as a proton transmembrane transporter from the mitochondrial intermembrane space into the matrix, causing proton leaks through the inner mitochondrial membrane, thereby uncoupling mitochondrial membrane potential generation from ATP synthesis . However, this function is controversial and uncoupling may not be the function, or at least not the main function, but rather a consequence of more conventional metabolite transporter activity . .
Accessions	ENST00000426995.2 [P55916-2] F5H3N5 ENST00000544614.1 A0A0S2Z4G2 A0A0S2Z4G5 P55916 ENST00000314032.9 [P55916-1]

UCP3 report