MECP2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0021794Biological processthalamus development
GO_0035865Biological processcellular response to potassium ion
GO_1901953Biological processpositive regulation of anterograde dense core granule transport
GO_0061000Biological processnegative regulation of dendritic spine development
GO_0021510Biological processspinal cord development
GO_2000635Biological processnegative regulation of primary miRNA processing
GO_0071514Biological processgenomic imprinting
GO_0044027Biological processnegative regulation of gene expression via chromosomal CpG island methylation
GO_1903941Biological processnegative regulation of respiratory gaseous exchange
GO_0043537Biological processnegative regulation of blood vessel endothelial cell migration
GO_0071317Biological processcellular response to isoquinoline alkaloid
GO_0001666Biological processresponse to hypoxia
GO_0021549Biological processcerebellum development
GO_0001662Biological processbehavioral fear response
GO_0001964Biological processstartle response
GO_0006020Biological processinositol metabolic process
GO_0035176Biological processsocial behavior
GO_0007585Biological processrespiratory gaseous exchange by respiratory system
GO_0019233Biological processsensory perception of pain
GO_0007219Biological processNotch signaling pathway
GO_0099611Biological processregulation of action potential firing threshold
GO_0010629Biological processnegative regulation of gene expression
GO_0060252Biological processpositive regulation of glial cell proliferation
GO_0010288Biological processresponse to lead ion
GO_1903860Biological processnegative regulation of dendrite extension
GO_0021756Biological processstriatum development
GO_0048712Biological processnegative regulation of astrocyte differentiation
GO_0008211Biological processglucocorticoid metabolic process
GO_0060291Biological processlong-term synaptic potentiation
GO_0021772Biological processolfactory bulb development
GO_0008542Biological processvisual learning
GO_0031507Biological processheterochromatin formation
GO_0050807Biological processregulation of synapse organization
GO_0042220Biological processresponse to cocaine
GO_0032048Biological processcardiolipin metabolic process
GO_0003229Biological processventricular cardiac muscle tissue development
GO_0010467Biological processgene expression
GO_0019230Biological processproprioception
GO_0032355Biological processresponse to estradiol
GO_0014003Biological processoligodendrocyte development
GO_0021766Biological processhippocampus development
GO_0031915Biological processpositive regulation of synaptic plasticity
GO_0010212Biological processresponse to ionizing radiation
GO_1905492Biological processpositive regulation of branching morphogenesis of a nerve
GO_0060079Biological processexcitatory postsynaptic potential
GO_0001976Biological processnervous system process involved in regulation of systemic arterial blood pressure
GO_0099191Biological processtrans-synaptic signaling by BDNF
GO_0006541Biological processglutamine metabolic process
GO_0051151Biological processnegative regulation of smooth muscle cell differentiation
GO_1901956Biological processpositive regulation of retrograde dense core granule transport
GO_0050432Biological processcatecholamine secretion
GO_0042551Biological processneuron maturation
GO_0090063Biological processpositive regulation of microtubule nucleation
GO_0060999Biological processpositive regulation of dendritic spine development
GO_0046470Biological processphosphatidylcholine metabolic process
GO_0021740Biological processprincipal sensory nucleus of trigeminal nerve development
GO_0007416Biological processsynapse assembly
GO_0043524Biological processnegative regulation of neuron apoptotic process
GO_0045892Biological processnegative regulation of DNA-templated transcription
GO_0006576Biological processbiogenic amine metabolic process
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0048286Biological processlung alveolus development
GO_0002087Biological processregulation of respiratory gaseous exchange by nervous system process
GO_0009791Biological processpost-embryonic development
GO_0007616Biological processlong-term memory
GO_0008344Biological processadult locomotory behavior
GO_1903861Biological processpositive regulation of dendrite extension
GO_0051707Biological processresponse to other organism
GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_0016525Biological processnegative regulation of angiogenesis
GO_0090327Biological processnegative regulation of locomotion involved in locomotory behavior
GO_0021591Biological processventricular system development
GO_0008104Biological processprotein localization
GO_0021987Biological processcerebral cortex development
GO_0016358Biological processdendrite development
GO_0014009Biological processglial cell proliferation
GO_0098978Cellular componentglutamatergic synapse
GO_0098794Cellular componentpostsynapse
GO_0005634Cellular componentnucleus
GO_0005654Cellular componentnucleoplasm
GO_0005615Cellular componentextracellular space
GO_0000792Cellular componentheterochromatin
GO_0005813Cellular componentcentrosome
GO_0005829Cellular componentcytosol
GO_0042802Molecular functionidentical protein binding
GO_0140693Molecular functionmolecular condensate scaffold activity
GO_0031490Molecular functionchromatin DNA binding
GO_0045322Molecular functionunmethylated CpG binding
GO_1990841Molecular functionpromoter-specific chromatin binding
GO_0060090Molecular functionmolecular adaptor activity
GO_0003682Molecular functionchromatin binding
GO_0010385Molecular functiondouble-stranded methylated DNA binding
GO_0140566Molecular functionhistone reader activity
GO_0042826Molecular functionhistone deacetylase binding
GO_0019904Molecular functionprotein domain specific binding
GO_0035197Molecular functionsiRNA binding
GO_0003729Molecular functionmRNA binding
GO_0003723Molecular functionRNA binding
GO_0005515Molecular functionprotein binding
GO_0003677Molecular functionDNA binding
GO_0003676Molecular functionnucleic acid binding
GO_0003714Molecular functiontranscription corepressor activity
GO_0000400Molecular functionfour-way junction DNA binding
GO_0008327Molecular functionmethyl-CpG binding

IV. Literature review

[source]
Gene nameMECP2
Protein nameMethyl CpG binding protein 2 isoform 7
Methyl CpG binding protein 2
Methyl CpG binding protein 2 isoform 2
Truncated methyl CpG binding protein 2 transcript 1
Methyl-CpG-binding protein 2 (MeCp-2 protein) (MeCp2)
Methyl-CpG binding protein 2
Methyl CpG binding protein 2 isoform 5
Methyl CpG binding protein 2 isoform 3
Methyl CpG binding protein 2 isoform 8
Mutant methyl CpG binding protein 2
Methyl CpG binding protein 2 transcript variant 1
Methyl CpG binding protein 2 isoform 6
SynonymshCG_37678
DescriptionFUNCTION: Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)-containing DNA, with a preference for 5-methylcytosine (5mC). .

FUNCTION: Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Mediates transcriptional repression through interaction with histone deacetylase and the corepressor SIN3A. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)-containing DNA, with a preference for 5-methylcytosine (5mC). .

FUNCTION: Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)-containing DNA, with a preference for 5-methylcytosine (5mC). .

FUNCTION: Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)-containing DNA, with a preference for 5-methylcytosine (5mC). .

FUNCTION: Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)-containing DNA, with a preference for 5-methylcytosine (5mC). .

FUNCTION: Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)-containing DNA, with a preference for 5-methylcytosine (5mC). .

FUNCTION: Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)-containing DNA, with a preference for 5-methylcytosine (5mC). .

FUNCTION: Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)-containing DNA, with a preference for 5-methylcytosine (5mC). .

FUNCTION: Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)-containing DNA, with a preference for 5-methylcytosine (5mC). .

AccessionsI6LM39
ENST00000630151.2
A0A0D9SEX1
A0A0S2Z3U3
D3YJ43
C6KG44
A0A0S2Z3Y9
A0A6Q8PF93
ENST00000637917.1
E9LUH3
C9JH89
C6KG45
ENST00000407218.5
E1B2J3
C6FGV0
A0A0S2Z3V4
A0A1B0GTV0
A0A0S2Z400
A0A0S2Z401
ENST00000369957.5
ENST00000303391.11 [P51608-1]
D5L9I5
ENST00000453960.7 [P51608-2]
A0A0S2Z3Z6
A0A0D9SFX7
ENST00000415944.3
B5MCB4
D0UU70
ENST00000628176.2
D9ZNA4
P51608
ENST00000674996.1
A0A075BPH5
A0A075BRI2
A0A075BRJ5
D6QZ43
D5L9I4
A0A075BNY0
A0A140VKC4
E9LUH4
A0A075BPP5
ENST00000675526.1
A0A6Q8PHQ3
H7BY72