PLEKHN1 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of PLEKHN1 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of PLEKHN1 at tissue level.

III. Associated gene sets

GO_0043065Biological processpositive regulation of apoptotic process
GO_0001666Biological processresponse to hypoxia
GO_0061158Biological process3'-UTR-mediated mRNA destabilization
GO_0031966Cellular componentmitochondrial membrane
GO_0005856Cellular componentcytoskeleton
GO_0005886Cellular componentplasma membrane
GO_0005739Cellular componentmitochondrion
GO_0070300Molecular functionphosphatidic acid binding
GO_1901612Molecular functioncardiolipin binding
GO_0001786Molecular functionphosphatidylserine binding
GO_0005515Molecular functionprotein binding
GO_1901981Molecular functionphosphatidylinositol phosphate binding

IV. Literature review

[source]
Gene namePLEKHN1
Protein namePleckstrin homology domain containing N1
Pleckstrin homology domain-containing family N member 1 (PH domain-containing family N member 1) (Cardiolipin and phosphatidic acid-binding protein)
SynonymsCLPABP
DescriptionFUNCTION: Controls the stability of the leptin mRNA harboring an AU-rich element (ARE) in its 3' UTR, in cooperation with the RNA stabilizer ELAVL1 . Decreases the stability of the leptin mRNA by antagonizing the function of ELAVL1 by inducing its atypical recruitment from the nucleus to the cytosol (By similarity). Binds to cardiolipin (CL), phosphatidic acid (PA), phosphatidylinositol 4-phosphate (PtdIns(4)P) and phosphatidylserine (PS) . Promotes apoptosis by enhancing BAX-BAK hetero-oligomerization via interaction with BID in colon cancer cells (By similarity). .

AccessionsENST00000491024.1
ENST00000379407.7 [Q494U1-3]
ENST00000379410.8 [Q494U1-1]
ENST00000379409.6 [Q494U1-2]
J3KSM5
Q494U1