CBFA2T3 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of CBFA2T3 at tissue level.

III. Associated gene sets

GO_0045820Biological processnegative regulation of glycolytic process
GO_1903715Biological processregulation of aerobic respiration
GO_0032436Biological processpositive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO_0006351Biological processDNA-templated transcription
GO_0008285Biological processnegative regulation of cell population proliferation
GO_0030851Biological processgranulocyte differentiation
GO_0001666Biological processresponse to hypoxia
GO_0045892Biological processnegative regulation of DNA-templated transcription
GO_0005730Cellular componentnucleolus
GO_0000139Cellular componentGolgi membrane
GO_0005654Cellular componentnucleoplasm
GO_0005634Cellular componentnucleus
GO_0003714Molecular functiontranscription corepressor activity
GO_0005515Molecular functionprotein binding
GO_0046872Molecular functionmetal ion binding

IV. Literature review

[source]
Gene nameCBFA2T3
Protein nameProtein CBFA2T3 (MTG8-related protein 2) (Myeloid translocation gene on chromosome 16 protein) (hMTG16) (Zinc finger MYND domain-containing protein 4)
CBFA2/RUNX1 partner transcriptional co-repressor 3
SynonymsMTGR2
MTG16
ZMYND4
DescriptionFUNCTION: Transcriptional corepressor which facilitates transcriptional repression via its association with DNA-binding transcription factors and recruitment of other corepressors and histone-modifying enzymes . Can repress the expression of MMP7 in a ZBTB33-dependent manner . Reduces the protein levels and stability of the transcriptinal regulator HIF1A; interacts with EGLN1 and promotes the HIF1A prolyl hydroxylation-dependent ubiquitination and proteasomal degradation pathway . Contributes to inhibition of glycolysis and stimulation of mitochondrial respiration by down-regulating the expression of glycolytic genes including PFKFB3, PFKFB4, PDK1, PFKP, LDHA and HK1 which are direct targets of HIF1A . Regulates the proliferation and the differentiation of erythroid progenitors by repressing the expression of TAL1 target genes (By similarity). Plays a role in granulocyte differentiation . .; FUNCTION: Isoform 2 functions as an A-kinase-anchoring protein . .

AccessionsENST00000562719.5
H3BR72
H3BMZ0
ENST00000569443.5
ENST00000566868.1
ENST00000570046.1
ENST00000268679.9 [O75081-1]
ENST00000327483.9 [O75081-2]
ENST00000564416.1
ENST00000569464.5
ENST00000563640.1
H3BU07
H3BNH2
J3QRB1
H3BSI4
O75081
H3BNI7